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10 Cards in this Set

  • Front
  • Back
pathophys of abo incompatibility
mom is O baby is A or B
mom has IgG against A and B from food source, and IgG crosses placenta --> hemolysis in utero and intrapartum
labs to eval neonatal abo incompatability
get neonatal type and DAT
if DAT +, follow bili and if bili high, check cbc and retic +/- smear for spherocytes
pathophys of rh incompatibility
mom is rh - and has IgG vs D antigen
IgG crosses placenta and destroys Ab coated RBCs
RBCs --> hemolysis and splenic sequestration --> anemia and high output CHF
how to prevent rh incompatability
give mom RhoGAM at 28 wks and also post-partum
how does RhoGAM work
its an Ig vs D Ag, it binds to any D Ag in mom's circulation from fetus and gets destroyed by the spleen
this way, mom never makes the IgG vs D Ag
sx of congenital rubella infx
cataracts/glaucoma
heart defects (PDA)
CNS (deaf, MR, behavior)
growth restriction
radiolucent bone dz
HSM
blueberry muffin rash
what is the risk assoc with 1mary syphilis in utero
40% risk of SAB, stillbirth or perinatal death
what is the risk assoc with 2ndary syphilis in utero
6-100% risk of transmission
sx of congenital syphilis
mucocutaneous lesions
snuffles
rash
HSM
LAD
osteochondritis
pseudoparalysis
hemolysis
thrombocytopenia
when do sx occur in congenital syphilis
can occur within the 1st week of life, and may be nml at birth