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73 Cards in this Set

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What makes up the endocrine system?

Endocrine glands


Hormones


Tropic hormones

Endocrine glands

Ductless


Secrete hormones directly into the blood stream

Hormones

Are carried throughout the body by the bloodstream


Initiate specific actions in target cells (cells that have receptors for that hormone)

Tropic hormones

Hormones that affect the release of other hormones


ex. Gonadotropins (LH and FSH) are hormones that affect the release of sex hormones from the gonads

In comparison to the nervous system, the endocrine system...

Acts using hormones


Can affect any cell in the body (target cells have hormone receptors)


Has widespread effects


Has slower but longer lasting responses

What are the three types of hormones?

Peptides


Steroids


Biogenic Amines

Peptides

Chains of amino acids (proteins)


Most common hormone type


Ex. Growth hormone (GH)

Steroids

Lipid derived from cholesterol


Ex. Testosterone

Biogenic Amines

Produced by altering a specific amino acid


Ex. Thyroid hormone

What are the 3 functions of the hypothalamus?

1. Produces regulatory hormones that either stimulate or inhibit anterior pituitary hormone secretion


2. Produces two hormones (oxytocin and antidiuretic) that are stored in and released from the posterior pituitary


3. Overseer of the ANS -- stimulates hormone secretion of the adrenal medulla via sympathetic ANS innervation

What is the posterior pituitary gland made of?

Nervous tissue

What is the anterior pituitary made of?

Glandular tissue


Not neural (nervous?) tissue


Cancer is more likely

Hypothalamo-hypophyseal portal system

Portal veins that shunt blood carrying regulatory hormones from hypothalamus to the anterior pituitary

Is cancer more likely in neurohypophysis or adrenohypophysis?

Adrenohypophysis (anterior pituitary)

Where are posterior pituitary hormones made?

Hypothalamus

Where are OT and ADH stored and secreted?

Posterior pituitary gland

Antidiuretic hormone (Vasopressin)

Initiates water reabsorption during dehydration

Increases blood pressure through vasoconstriction


Hyposecretion causes diabetes insipidus



Oxytocin

Uterine contractions and milk ejection

Which of the anterior pituitary hormones are tropic hormones?

FSH


LH


ACTH


TSH

What does GH act on?

all body tissues, especially bone, muscle, and adipose tissue

Pituitary Dwarfism

Hyposecretion of GH in children

Hyposecretion of GH in children

Pituitary Dwarfism

Pituitary Gigantism

Hypersecretion of GH during childhood

Hypersecretion of GH during childhood

Pituitary gigantism

Acromegaly

Hypersecretion of GH during adulthood (after the epiphyseal plates have closed)

Hypersecretion of GH during adulthood (after the epiphyseal plates have closed)

Acromegaly

What shape is the thyroid gland?

Butterfly shaped

Where is the thyroid gland located?

Inferior to the larynx

Which is the largest pure endocrine gland in the body?

Thyroid gland

Calcitonin

Decreases blood calcium


Decreases osteoclast activity and increases osteoblast activity

What are the 3 thyroid hormone disorders?

Endemic goiter


Hyperthyroidism


Hypothyroidism

Endemic goiter

Dietary iodine deficiency

Hyperthyroidism

Excessive TH production


High metabolic rate, weight loss, hyperactivity, always feeling hot, tachycardia

Hypothyroidism

Decreased production of TH


Low metabolic rate, weight gain, fatigue, always feeling cold

Where are parathyroid glands located

On the posterior surface of the thyroid gland

Parathyroid hormone

Increases blood calcium


Increases osteoclast activity and decreases osteoblast activity

Where is the thymus located?

In the lower neck and mediastinum


What happens to the thymus after puberty?

It yellows and atrophies

What are corticosteroids?

The steroid hormones from the adrenal cortex


Ex. cortisol

What do corticosteroids do?

Act on the immune system by blocking inflammation


Inhibit white blood cells

What is a side-effect of corticosteroids?

Increased susceptibility to infection

Which diseases do we treat with corticosteroids?

Inflammatory diseases:


Rheumatoid arthritis


Lupus


Inflammatory bowel disease

Should corticosteroids be used for a long period of time?

No

What are disorders of the adrenal cortex?

Cushing syndrome


Addison Disease

Cushing syndrome and symptoms

Hypersecretion of cortisol


Symptoms:


Redistributed body obesity


"Moon face"


"Buffalo hump"


Kidney stones


Skin becomes fragile and thin

Addison disease and symptoms

Hyposecretion of cortisol


Symptoms:


Weight loss


General fatigue


Hypotension (low blood pressure)

Where is the pancreas located?

In the posterior wall of abdominal cavity

What do pancreatic islets (islets of Langerhans) produce?

Alpha and beta cells

Glucagon

Secreted by alpha cells


Glycogen breakdown in the liver


Increases blood glucose levels

Insulin

Secreted by beta cells


Signals body cells to take up glucose


Decreases blood glucose levels

Which type of diabetes is usually diagnosed in childhood?

Type I Diabetes

Type I Diabetes

Autoimmune disorder


Absent or diminished production and release of insulin by the pancreatic islet cells


"Insulin dependent"


Develops suddenly

Type II diabetes

Decreased insulin release or decreased insulin effectiveness


"Insulin independent"


Develops more slowly

Gestational Diabetes

Diabetes that develops during pregnancy


20-50% chance of developing Type II later in life

Define diabetes mellitus

Insufficient secretion of insulin or resistance of body cells to effect of insulin

Trophic hormone from anterior pituitary gland: follicle stimulating hormone

stimulates maturation of sperm and follicle cells

trophic hormone from anterior pituitary gland: luteinizing hormone

stimulation of sex hormones in males and females

hormone from anterior pituitary gland: melanocyte stimulating hormone

stimulates melanocytes of epidermis to produce melanin

hormone from thyroid gland: calcitonin

prevents loss of calcium from bone -puts calcium IN bone and decreases blood calcium levels in the blood

hormone from parathyroid gland: parathyroid hormone

increases blood calcium levels in the blood -takes calcium out of bone

type II diabetes is insulin ___________

independent

type I diabetes is insulin ____________

dependent

hormone from pancreas: glucagon

-enhances breakdown of glycogen in liver


-your body uses this when you are fasting, blood sugar stores in the liver and cells get released

hormone from pancreas: insulin

-takes blood sugar and puts it into the cells


-storage of glycogen in liver and muscle cells

What are the corticosteroids?

CACA

hormone from adrenal cortex: aldosterone

regulates sodium and water eliminated by kidney tubules

hormone from adrenal cortex: cortisol

-anti inflammatory and anti stress-lowers immune system

hormone from adrenal medulla: norepinephrine and epinephrine

-increases blood pressure -sympathetic response-fight or flight

hormone from testes: testosterone

development of male sex organs

hormone from ovaries: estrogen

induces development and controls the function of female repro organs

hormone from ovaries: progesterone

-maturation of uterine endometrium (lining of uterus)


-implantation of a fertilized egg

hormone from placenta: human chorionic gonadotropin

acts on the corpus luteum

what hormone is detected in a pregnancy test?

HCG, human chorionic gonadotropin