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36 Cards in this Set
- Front
- Back
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Picorna
what type of Hep and what transmission |
Hep A
Rna virus self limiting therefore no therapy |
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Hepadna
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Hep B
DNA virus transfusion, sexual, IV drugs, birth |
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Flavi
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Hep C
Rna virus transfusion, iv drugs, sexual, birth |
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what does Adefovir treat
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treats HBV
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what does interferon gamma treat
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HBV and HBC
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what does Ribavirin treat
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HCV
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what does Lamivudine treat
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HBV
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what are the properties of adefovir
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prodrug
activity against RNA and DNA virus competitively inhibits viral DNA polymerase or viral RTase CHAIN TERMINATION |
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what works at the same acidic transporter as Cidofovir and what is the effect of probenecid on it
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adefovir
probenacid is not preadministered |
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what strain on Hep has an RTase
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HBV
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what is the ADME of adefovir
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oral delivery
eliminated unchanged in the urine |
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what are the adverse effects of Adefovir
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nephrotoxicity (reversible)
monitor liver enzymes after d/c should go up |
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what are the properties of HCV
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has its own RNA polymerase (Replicase)
Doesn't repicate its RNA > DNA has protease (Serine) NO INTEGRATION INTO HOST CELL |
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what kind of protease does HIV have
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aspartyle
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what drugs are used to treat HBV
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telbivudine
Tenofovir Entecavir lamivudine adefovir interferon gamma |
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what are the properties of Telbivudine
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thymidine analog
treats HBV inhibits HBV DNA polymerase RTase |
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what drugs are used in lamivudine resistant infections
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Telbivudine
Entecavir |
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what are the properties of Tenofovir
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used to treat HIV can also be used to treat HBV infections
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what are the properties of Entecavir
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treats HBV
deoxyguanasine analog competitively inhibits HBVs polymerase (DNA polymerase RTase) |
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when is interferon made
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whenever we encounter double stranded nucleic acid
viral infections |
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what interferon is for leukocytes
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interferon alpha
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what interferon is for fibroblasts
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interferon beta
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what interferon is for T lymphocytes
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interferon gamma
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what induces the antiviral activity of interferon
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double stranded nucleic acid
induced when treating cells w/ interferon |
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what is the basic model for interferon release
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activate Jak-Stat resulting in the transcribing in ISG (interferon stimulated genes)
can degrade mRNA or inhibit proteins |
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what are the two important interferon genes
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2'5' oligoadenylate (causese degredation of mRNAs)
protein kinase (inhibits translation) |
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what are the properties of interferons antiviral action
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must be given via chronic parenteral therapy
pegylated interferon is better because it remains in circulation longer rather than be degraded by serum proteins |
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what are the adverse reactions of interferon
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bone marrow suppression
cns symptoms bad cold or flu |
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how is interferon ADME
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IM, SQ
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what are the properties of Ribavirin
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inhibits both RNA and DNA viruses
works on Hep C in combo w/ interferon |
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what is a 1st line drug for Hep C chronic
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ribavirin
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what is the MOA of Ribavirin
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phosphorylated by cellular kinase
monophosphate ribavirin -inhibits inosine monophosphate dehydrogenase which is critical for synthesis of guanosine triphosphate ribavirin -inhibits RNA polymerase causing chain termination |
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what is the dosage forms of RIbavirin
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aerosol
parenteral oral accumulates in RBC |
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what are the ADR of Ribavirin
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contraindicated for pregnancy
reversible anemia |
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what is the MOA of non-nucleotide replicase inhibitors (NNRRIIs)
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decrease affinity of replicase for RNA by binding to a site distal to the active site
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what is the MOA of non-nucleoside replicase inhibitors (NRRIs)
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chain terminators (don't do this by not having 3'OH) but cause steric hinderance at the elongation site
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