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96 Cards in this Set
- Front
- Back
Ethosuximide
|
Absence seizures; photophobia & hiccups
|
|
Phenytoin
|
Tonic clonic & partial seizures
Pseudo zero-order metabolism |
|
Carbamazepine
|
T-C & CP
Classic; few side effects |
|
Phenobarbital
|
T-C & CP
Classic; sedating |
|
Primidone
|
T-C & CP
Phenobarbital prodrug |
|
Valproate
|
Broad spectrum of seizures + bipolar disorder
Exact MOA unknown; NA+-channel blockers? Side effects: bruising, bleeding, hair loss |
|
Clonazepam
|
Seizures
First benzo; sedative |
|
Clobazam
|
Seizures
Sedative, maybe not as bad |
|
Vigabatrin
|
Seizures
Tunnel vision, loss of visual acuity |
|
Gabapentin
|
Not GABAergic
Good add-on |
|
Lamotrigine
|
Seizures
Rare life-threatening rash |
|
Levitiracetam
|
Seizures
Raises thresholds only slightly; not picked up by animal model screens |
|
Oxcarbazepine
|
Seizures
Carbamazepine sibling with fewer side effects |
|
Topiramate
|
Seizures
Sedating, weight loss |
|
Zonisamide
|
Seizures
|
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Felbamate
|
Seizures
Not approved in Canada |
|
Pregabalin
|
Seizures
Neuropathic pain |
|
Diazepam, lorazepam
|
Status epilepticus & anxiety
Potentiate GABAergic inhibition |
|
Buspirone
|
GAD
Partial agonist at 5HT1A Presynaptic inhibtion of 5HT release Postsynaptic encouragement of K+ efflux |
|
Zolpidem, zopiclone, zaleplone
|
Insomnia
Binds BZD site on GABA-R |
|
Gaboxadol
|
Insomnia
Agonist at extrasynaptic GABA-A |
|
Ramelteon
|
Insomia
MT1 (melatonin) agonist |
|
Amitryptiline, imipramine
|
MDD
Tricyclic 5HT & NE reuptake inhibitor |
|
Moclobamide, phenelzine
|
MAOIs
|
|
Fluoxetine
|
MDD
5HT reuptake inhibitor Inhibit 2D6 & 3A4 |
|
Venlafaxine
|
5HT, NE reuptake inhibitor
|
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Lithium
|
Bipolar
Inhibit signal transduction & 2nd messenger systems |
|
Amoxapine
|
MDD
Dibenzoxazepine derivative |
|
Maprotiline
|
MDD
Tetracyclic NE reuptake inhibitor, weak 5HT reuptake inhibitor & anticholinergic |
|
Bupropion
|
MDD, SAD
Weak NE/DA reuptake inhibitor Used in elderly & SSRI-resistant patients Inhibits 2D6 |
|
Metocloperamide
|
Migraines
DA antagonist to prevent N/V |
|
Nonspecific migraine medications
|
NSAIDs, antihistamines, opiates
|
|
Lidocaine
|
Migraines
Nasal drops (inconvenient) |
|
Ergotamine
|
Migraines
5HT partial agonist (presynaptic block of 5HT-1B/D & 5HT-2) |
|
Sumatriptan
|
Migraines
5HT-1B/D agonist (vasoconstriction, inhibiting release of neurogenic peptides) |
|
Donepezil, rivastigmine, galantamine
|
AD
Cholinesterase inhibitors |
|
Memantine
|
AD
Competitive NMDA antagonist |
|
Other AD/cognitive enhancers
|
Gingko biloba
Vitamin E Caffeine |
|
Tetrabenzamine
|
Huntington's
DA depletor |
|
Amantadine
|
Huntington's (motor)
DA antagonist |
|
Sulpride
|
Huntington's (motor)
DA antagonist |
|
L-dopa
|
Huntington's (rigidity), Parkinson's
DA precursor |
|
Modafinil
|
Huntington's (cognitive)
NE, DA stimulant |
|
Other Huntington's drugs
|
ChEIs, SSRIs, SNRIs, TCAs, valproate, coenzyme Q, riluzole, creatine, minocycline, lax 101
|
|
Cardidopa
|
Peripheral dopa decarboxylase inhibitor
|
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Benserazide
|
Parkinson's
Peripheral dopa decarboxylase |
|
alpha-methyltyrosine
|
Precipitate Parkinson's (research)
|
|
Deprenyl/selegiline
|
Parkinson's
MAO-I, prevent GAPDH nitrosylation & nuclear protein degradation |
|
MDMA
|
Parkinson's
Enhance L-dopa activity |
|
Metrazole, mikelthimide
|
Alcohol OD
Stimulants (analeptics) - physiological antagonism |
|
RO 15-4513
|
Alcohol OD
BZD reverse agonist (produce anxiety) |
|
Disulfiram
|
Alcoholism
Alcohol dehydrogenase inhibitor |
|
Acamprosate
|
Alcoholism
Glutamate receptor modulator |
|
Etorphine
|
Pain (opioid)
Very strong |
|
Codeine
|
Pain
|
|
Dihydrocodone
|
Pain
|
|
Fentanyl
|
Pain & neuroleptanalgesia
80x more potent than morphine |
|
Hydromorphone/hydrocodone
|
Pain, cough
|
|
Meperidine
|
Pain
Muscarinic effects |
|
Oxycodone
|
Pain
Long-acting |
|
Pentazocine
|
Pain
Kappa agonist, mu antagonist |
|
Buprenorphine
|
Pain
Partial opiate agonist |
|
Nalmefone
|
Opiate OD
Antagonist |
|
Naloxone
|
Opiate/alcohol OD
Antagonist |
|
Naltrexone
|
Alcoholism
Opiate antagonist |
|
SPA
|
Gold standard reward drug (research)
|
|
Haloperidol
|
Schizophrenia
DAR antagonist |
|
Chlorpromazine
|
Schizophrenia
DAR antagonist |
|
Clozapine
|
Schizophrenia
DAR antagonist + other NT effects |
|
Olanzapine
|
Schizophrenia
DAR antagonist + other NT effects |
|
Risperidone
|
Schizophrenia
DAR antagonist + other NT effects |
|
Quetiapine
|
Schizophrenia
DAR antagonist + other NT effects |
|
Ziprasidone
|
Schizophrenia
DAR antagonist + other NT effects |
|
Aripiprazole
|
Schizophrenia
DA/5HT stabilizer (Ant mesolimbic, 5HT2; Ag mesocortical, 5HT1) |
|
Spironolactone
|
Hyperaldosteronism, hypertension, edema
MR competitive antagonist |
|
Hydrocortisone
|
Cortisol replacement
|
|
Prednisolone
|
Cortisol replacement
Separated GC, MC activity |
|
Fludrocortisone
|
High MC activity
|
|
Dexamethasone, betamethasone, triamcinolone
|
GC replacement, including life-threatening inflammation
|
|
Cortisone, prednisone
|
Cortisol replacement (back-converted from ketone; cheaper)
|
|
Ketoconazole
|
Hypercortisolism
Inhibit P17A (synthesis) |
|
Metyrapone
|
Hypercortisolism
Inhibit 11beta-hydroxylase (synthesis) |
|
Mitotane
|
Adrenocortical carcinoma
Cytotoxic |
|
Levothyroxine sodium
|
TH replacement
T4 |
|
Liothyronin
|
TH replacement
T3 |
|
Thionamids
|
Hyperthyroidism
Inhibit peroxidase |
|
Radioactive sodium iodide
|
Hyperthyroidism
Local emission of beta particles |
|
17beta-estradiol
|
HRT
|
|
Premarin
|
HRT; low potency
Sulfonated |
|
Ethinyl estradiol
|
PO contraceptives
17alpha-alkyl estrogens high potency |
|
Medroxyprogesterone acetate
|
HRT
Protective for endothelium (progesterone) |
|
Norethindrone, norgesterl, desorgestrel
|
HRT
17-alkyl-19-nor-testosterones |
|
Clomiphene
|
Fertility
Promotes FSH, LH release (multiple follicles mature) |
|
Tamoxifen
|
Breast cancer
SERM |
|
Anastrazole, letrozole
|
Breast, uterine cancers
Competitive inhibition of aromatase |
|
Exemestane
|
Breast, uterine cancer
Steroidal non-competitive aromatase inhibition |