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12 Cards in this Set
- Front
- Back
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ANP |
made by atrial myocytes membrane GC-A --> GTP --> cGMP --> 1. increase natiuresis (Na+water) 2. decrease PVR 3. supress renin-angiotensin system --> decrease BP |
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BNP |
made by ventricular myocytes
*same mechanism as ANP |
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CNP |
made by vascular cells.
*same mechanism as ANP but with GC-B/GC-C |
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NO |
produced by ENos in endothelial cells lining the smooth muscles.
binds to sGC-->GTP-->cGMP --> decrease MLCK activity --> decrease muscle contraction. |
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Nitroglyercine |
2 minute half life acute treatment of angina pectoris releases 3 NO
side effects: migraines/headaches, tolerance |
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Isosorbide dinitrate |
1 hour half life prophylatic treatment of angina pectoris
releases 2 NO. |
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Isosorbide mononitrate |
5 hour half life prophylatic treatment of angina pectoris
releases 1 NO. |
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theophylline |
methylxanthine found in tea higher efficacy than caffeine increased cortical arousal, alertness and bronchodilation
side effects: increased gastric acid secretion, digestive enzyme secretion, weak diuretic, increased myocardial contraction, relaxation of smooth muscle. |
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caffeine |
methylxanthine found in coffee beans
same as "theophylline" |
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rolipram |
PDE4 inhibitor treats depression
side effects: nausea, GI disturbance and emesis |
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Sildenafil |
PDE5 inhibitor treats ED
side effects: headaches, flushing, dyspepsia, "blue vision" (PDE6 in retina)
duration of action: 4-5 hours. |
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Tadalafil |
Same as sildenafil.
Duration of action: 17.5 hours. |
