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14 Cards in this Set

  • Front
  • Back
Blisters or bullae can arise due to several different causes, however, all of these causes are linked by what primary dysfunction?
A weakening of localized areas within the skin layers causes fluid to accumulate between tissue layers.
What are some of the ways that blisters can manifest?
Blistering may occur as a secondary event associated with (1)viral or (2)bacterial infections of the skin (e.g. herpes simplex) and impetigo, or with local injury of the skin (e.g. burns, ischemia and dermatitis).
Genodermatoses assocatiead with blisters are typically manifested in?
Neonates, whereas autoimmune blistering disorders are acquired and usually expressed later in life.
What is a vesicle? Is it different from a blister?
A vesicle is a fluid-filled cavity or elevation smaller than or equal to 0.5 cm, whereas a bulla (blister) measures larger than 0.5 cm. The fluid in the cavity exerts equal pressure in all directions to give rise to a spherical shape. Vesicles tend to rupture easily and may be noted as an erosion or white thin plaque
Where is cleavage in tense bullae commonly located?
Cleavage in tense bullae are commonly located at the dermal-epidermal junction (DEJ).
What type of blisters are usually the result of mechanical fragility, autoimmunity or genetic alteration of a component of the basement membrane zone?
Sub-epidermal blisters.
How are blisters formed?
Blisters are formed as a result of a breakdown of tissue integrity and fluid accumulation in a specific compartment of the skin (i.e. subcorneal, suprabasilar, DEJ, or upper dermis).
What does the presence of blisters in many patients signify?
The presence of blisters in many patients is secondary to another subcutaneous disease.
Local hypoxia secondary to decreased cutaneous blood flow can produce what?
In which epidermal compartments can blisters arise?
Blisters can arise in the epidermis (limited by the stratum corneum on the outside and the basal cell layer on the inside); the DEJ or lamina lucida (limited by the cell surface of basal keratinocytes and the lamina densa); and the dermis (tissue located below the lamina densa).
The kertainocyte system plays a role in the pathogenesis of what?
Blister formation in lesions in the epidermal and DEJ compartments.
What provides the melanin pigment?
A network of melanocytes closely interacting with the keratinocyte cell system producing the melanin pigment, which is important in filtering out harmful environment UV radiation.
What is the role of Langerhan Cells?
Langerhan Cells compose a network of antigen-presenting cells involved in immunologic mechanisms.
Friction blisters occur as a result of what?
Friction blisters occur as a result of mid-epidermal necrosis.