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7 Cards in this Set
- Front
- Back
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What is giantism?
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-increased GH in childhood
-overgrowth of long bones -increase activity of the bones at the epiphyseal plates |
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What is acromegaly?
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increased GH in adults
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Which bones are affected in giantism?
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long bones
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Which bones are affected in acromegaly?
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short bones (facial bones, hands, feet)
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What is the significance of connective tissue changes in acromegaly?
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enlargement of the visceral organs w/ connective tissue changes
-LV failure is prominent -nerves can become entrapped r/t overgrowth of bone & skin: foot drop, muscular atrophy, weakness |
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What are the metabolic effects in acromegaly?
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-increase metabolic rate & decrease carbohydrate tolerance (loss of insulin sensitivity from increased GH, connective tissue in pancreas becomes fibrotic)
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What is often the cause of acromegaly?
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somatotropic pituitary tumor
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