Pathology_4 03: Nhl

Front 1

7 T-cell asocciated CD molecules

Back 1

CD1-5
CD7
CD8

Front 2

CD45 is present on ___ but not on ___

Back 2

nearly all hematolymphoid cells
HLy cells

Front 3

CD10 aka ___ is present on ___

Back 3

CALLA
immature B cells

Front 4

CD20 is present on ___ but not ___

Back 4

all mature B cells
plasma cells

Front 5

CD23 is ___ and is present on ___ (2)

Back 5

IgE R
activated mature germinal center B cells
follicular dendritic cells

Front 6

CD79a is ___ and is present on ___

Back 6

mIg
pre-B through plasma cells (?)

Front 7

CD138 is ___ and is present on ___

Back 7

adhesion molecule
late stage B cell differentiation including plasma cell

Front 8

CD5 is expressed by most ___ and some ___

Back 8

T cells
B cells

Front 9

CD15 and CD30 are present on ___

Back 9

Reed-Sternberg cells

Front 10

CD34 is present on

Back 10

HSCs

Front 11

2 most common lys

Back 11

DLBCLy
FLy

Front 12

ALL and LBLy can be caused by ___ (2) cells

Back 12

pre-B
pre-T

Front 13

when caused by pre-B cells, ALL/LBLy will be positive for ___ (4)

Back 13

CD10
CD19
CD79a
TdT

Front 14

when caused by pre-T cells, ALL/LBLy will be positive for ___ (4)

Back 14

CD2
CD5
CD7
TdT

Front 15

80% of LBLy is from ___ cells.
80% of ALL is from ___ cells.

Back 15

T
B

Front 16

ALL is mostly in ___ (age).
LBLy is mostly in ___.

Back 16

kids under 4
adolescent males

Front 17

lymphoblasts have ___ chromatin

Back 17

thin

Front 18

the same kind of B cell causes ___ and ___

Back 18

small lymphocytic ly
CLL

Front 19

___ is always positive for neoplastic cells in ___, and usually in ___.

Back 19

BM
CLL
SLLy

Front 20

___s are vague nodular areas with large cells with prominent nucleolus, characteristic of ___

Back 20

proliferation center
CLL/SLLy

Front 21

CLL/SLLy (naive B cell) phenotype (4)

Back 21

CD5
CD20 (weak)
CD23
CD43

Front 22

10% of CLL/SLLy transform to ___. the switch is called ___.

Back 22

DLBCLy
Richter's syndrome

Front 23

translocation for MCL
it is not completely ___ for MCL
the effect is ___.

Back 23

t(11;14)
specific
upregulation of cyclin D1 (Bcl-1)

Front 24

MCLy cells are ___ sized with ___ nuclei, ___ nucleoli and ___ cytoplasm

Back 24

small-medium
irregular
small
scant

Front 25

in MCLy follicles are ___

Back 25

absent

Front 26

MCLy phenotype

Back 26

CD5
CD20
CD43
Bcl-1

Front 27

FLy follicles lack ___.
___ are always present between FLy follicles

Back 27

mantle zone
neoplastic cells

Front 28

translocation for FLy
this causes ___
the effect is ___.

Back 28

t(14;18)
overexpression of Bcl-2
prevention of apoptosis

Front 29

T/F: prognosis for FLy is worse with t(14;18)

Back 29

false

Front 30

2 kinds of cells in FLy

Back 30

centrocyte
centroblast

Front 31

centrocyte is aka ___
centroblast is aka ___

Back 31

small cleaved follicular center cell (FCC)
large non-cleaved FCC

Front 32

phenotype of FLy (germinal center) cells (4)

Back 32

CD20
CD10
Bcl-2
Bcl-6

Front 33

centrocytes are more ___ and centroblasts are more ___ and have ___

Back 33

purple
pink
prominent nucleolus

Front 34

grade 1 FLy is ___ (2)
grade 3 FLy is ___ (2)

Back 34

indolent
incurable
aggressive
curable with chemo

Front 35

grade 1 FLy can transform to ___ (2)

Back 35

grade 3 FLy
DLBCLy

Front 36

MZLy and maltoma have ___ nuclei and ___ cytoplasm. they are caused by ___ cells

Back 36

irregular
clear
marginal memory (post-germinal-center) B cells

Front 37

4 stages of MZLy

Back 37

infiltration around follicles
follicular colonization
diffuse infiltrate
invasion of surrounding epithelium

Front 38

3 diseases caused by marginal memory B cell

Back 38

MZLy
splenic MZLy
extra-nodal MZLy

Front 39

extra-nodal MZLy is aka

Back 39

MALToma

Front 40

phenotype of marginal memory B cell (3)

Back 40

CD20
CD79a
CD43+/-

Front 41

MALTomas are commonly caused by inflammation caused by ___ (3)

Back 41

H. pylori
B. burgdorferi
autoimmune disease

Front 42

T/F: treating causative infection can cure the MALToma

Back 42

true

Front 43

small B Lys with CD5-, CD10+

Back 43

FLy

Front 44

small B Lys with CD5+, CD10-

Back 44

CLL/SLLy
MCLy

Front 45

small B Lys with CD5-, CD10-

Back 45

MZLy

Front 46

although both are CD5+, CD10-, CLL/SLLy are ___ whereas MCLy is ___.

Back 46

CD23+
Bcl-1+

Front 47

in DLBCLy, nucleus is at least ___ the size of ___

Back 47

twice
normal lymphocyte

Front 48

in DLBCLy, ___ is most common site of extranodal involvement

Back 48

GIT

Front 49

DLBCLy has ___ markers with initial phenotype ___ (3), and eventually with ___ (3) also.

Back 49

mature B cell
CD19
CD20
CD79a
CD10
Bcl-2
Bcl-6

Front 50

translocation in Burkitt's ly
this causes ___

Back 50

t(8;14)
overexpression of c-MYC (chromosome 8) by Ig promoter (chromosome 14)

Front 51

in locations such as ___ where BLy is endemic, ___ is present in tumor cells

Back 51

africa
EBV DNA

Front 52

BLy has ___ appearance with interspersed ___s

Back 52

starry sky
tingible body MQ

Front 53

plasma cell monoclonality can be dx if ___ ratio isn't approximately ___

Back 53

kappa/lambda
3

Front 54

plasma cell phenotype

Back 54

CD38
CD138

Front 55

___ is a morphological variant of a plasma cell

Back 55

Mott cell

Front 56

T/F: MM cells generally have normal morphology

Back 56

true

Front 57

___ morphology and ___ are associated with bad MM prognosis

Back 57

plasmablastic
high Ki67 index

Front 58

plasmablasts look like ___ cells

Back 58

DLBCLy

Front 59

MM prognosis is based mostly on ___

Back 59

BM infiltration

Front 60

dx of MM requires ___% BM plasmacytosis

Back 60

>30

Front 61

___ is a plasma cell tumor without systemic effects

Back 61

plasmacytoma

Front 62

2 kinds of plasmacytoma

Back 62

solitary p of bone
extraosseous p

Front 63

3 most common sites for solitary plasmacytoma of bone
___% develop MM within 10 years

Back 63

vertebrae
ribs
skull
55

Front 64

most common site for extraosseous plasmacytoma
MM is common/rare

Back 64

respiratory tract
rare

Front 65

most common T-cell ly

Back 65

peripheral T cell ly, unspecified

Front 66

2 kinds of anaplastic large cell ly

Back 66

ALK+
ALK-

Front 67

most ALCLy is ALK ___

Back 67

positive

Front 68

ALK is a ___ produced by ___

Back 68

Y kinase
translocation

Front 69

___ (2) are skin conditions caused by T cell tumors. the cells have irregular ___ nuclei, and cause ___

Back 69

Mycosis fungoides
Sezary syndrome
cerebriform
Pautrier microabcesses

Front 70

phenotype of epidermotropic T cell

Back 70

CD3
CD4
CD5

Front 71

___ has leukemic syndrome with erythroderma

Back 71

Sezary syndrome