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35 Cards in this Set
- Front
- Back
3 morphological changes in cirrhosis
|
bridging fibrosis
loss of architecture regenerative nodules |
|
micronodules are <___ in diameter
|
3mm
|
|
3 main causes of death from cirrhosis
|
hepatic coma
hematemesis from esophageal varices HCC |
|
3 kinds of alcoholic liver disease (ALD)
|
fatty liver
alcoholic hep alcoholic cirrhosis |
|
fatty liver is grossly ___
fatty liver typically weighes ___ kg |
large
soft yellow 4--6 |
|
alcoholic hep is caused by ___. ___ may be seen inside ___.
|
bout of heavy drinking
mallory bodies damaged hepatocytes |
|
T/F: alcoholic hep is always reversible
|
false
|
|
early in alcoholic cirrhosis liver is grossly ___ (3). later it is ___ (3).
|
large
yellow fatty shrunken brown non-fatty |
|
men/women are more susceptible to alcoholic damage
|
women
|
|
postnecrotic cirrhosis is ___nodular
|
macro
|
|
4 causes of postnecrotic cirrhosis
|
HBV/HCV
hepatotoxins/drugs massive liver necrosis end stage alcoholic cirrhosis |
|
most common cause of postnecrotic cirrhosis
|
chronic viral hep
|
|
3 kinds of biliary cirrhosis
|
1' (PBC)
2' 1' sclerosing cholangitis (PSC) |
|
___ hepatocyte degeneration is present in all biliary cirrhosis
|
feathery
|
|
PBC is caused by
|
autoimmune attack on intrahepatic bile ducts
|
|
PBC is more common in men/women
|
women (6:1)
|
|
auto Ab in PBC
|
antimitochondrial (AMA)
|
|
3 histopath findings in PBC
|
granulomas
periportal hep with mallory bodies fibrosis -> cirrhosis |
|
SBC is caused by ___. this may happen in ___ or ___.
|
chronic obstruction of biliary tree
CF tumor |
|
___ is a complication of SBC
|
ascending cholangitis
|
|
macroscopically PBC and SBC have ___ cirrhosis, with ___ (2) liver
|
micronodular
hard green |
|
4% of IBD have ___
|
PSC
|
|
___% of PSC patients have IBD
|
70
|
|
PSC is more common in men/women
|
men
|
|
histopath finding in PSC: ___ followed by ___.
|
cholangitis
onion skin fibrosis of small and large bile ducts |
|
PSC is dxed by ___
|
ERCP
|
|
1' hemochromatosis is a ___ trait. more common in men/women
|
AR
men |
|
2' hemochromatosis is caused by ___.
|
hemolysis
|
|
in 1' hemochromatosis Fe accumulates in ___ (6)
|
liver
pancreas heart endocrine glands joints skin |
|
risk of ___ is dramatically increased in hemochromatosis
|
HCC
|
|
Wilson's disease damages ___ in brain
|
basal ganglia
|
|
T/F: liver transplant cures 1' hemochromatosis
|
false
|
|
T/F: liver transplant cures Wilson's disease
|
true
|
|
T/F: liver transplant cures A1AT deficiency
|
true
|
|
___ cells located in ___ produce ___ and cause ___
|
Ito
space of Disse collagen fibrosis |