Pathology Haematology

Front 1

Microcytic anaemia causes

Back 1

↓Fe

chronic disease

thalassaemia

Sideroblastic

FeTCheS

Front 2

Normocytic anaemia causes

Back 2

↓Blood

Chronic disease

↓BM

↓Renal

↓ thyroid

Haemolysis

Pregnancy

Front 3

Macrocytic anaemia causes

Back 3

↓B12/folate

ETOH/liver disease

reticullocytosis

myelodysplasia

↓thyroid

antifolate drugs - phenytoin

Front 4

Heinz bodies

Back 4

G6PD def

chronic liver disease

Front 5

Howell Jolly

Back 5

Nuclear remnants

SCA, IBD, megaloblastic anaemia

How jolly this DNA is playing SIMs

Front 6

Pelger Huet

Back 6

HypOsegmented neutrophils

myelodysplastic

Front 7

Right shift

Back 7

mature > immature

HypERsegmented neutrophils

megaloblastic anameia

Front 8

Rouleux formation

Back 8

myeloma

Front 9

Schistocytes

Back 9

Fragmented RBCs

HUS, TTP

Front 10

Stomatocytes

Back 10

Central pallor

Hereditary, ETOH, liver disease

Front 11

Target cells

Back 11

Liver, ↓Fe anameia, thalassaemia, hyposplenism

Front 12

Spherocytosis has mutations in what proteins

Back 12

Spectrin + ankarin - RBC membrane prots

Front 13

G6PD

Back 13

Heinz bodies, bite cells

X linked rec

RF: sulfonamides, aspirin, broad beans

Beans - heinz

Front 14

SCA

Back 14

glu-val

HbS

Front 15

COOMBs

Back 15

DAT, autoimmune haemolytic anaemia

Front 16

WAIHA

Back 16

Warm autimmune HA

IgG

+ve COOMBs

Front 17

Cold agglutanin

Back 17

IgM

Rx chlorambucil

+ve COOMBs

Front 18

PNH

paroxysmal nocturnal haematuria

Back 18

aquired

coombs -ve

Front 19

Thrombotic thrombocytopenic purpura

Back 19

microangiopathic HA (MAHA),

fever, ↓ renal, ↓neuro, thrombocytopenia

Front 20

Haemolytic uraemic syndrome

Back 20

E.coli, ↓renal, MAHA, NO neuro

Front 21

Clotting cascade

Back 21

INTRINSIC EXTRINSIC

12→1→9→8→10→ ← 7

5 →thrombin(II)→fibrin(I)→clot

clot + plasmin→clot degredation

Front 22

Haemophilia A + B

Back 22

↑ APTT, normal PT

A - ↓VIII

B - ↓IX

Front 23

APTT + PTT measure what

Back 23

APTT - intrinsic

PTT - extrinsic

Front 24

von Willebrand's

Back 24

↓plt fxn, ↓VIII, ↓vWF, ↑APTT, ↑bleeding time

Normal INR + plt count

Front 25

Vit K required for synthesis of

Back 25

II, VII, IX, X, prot C+S

Front 26

↑clotting causes

Back 26

↓prot C +/or S, factor v leiden, malignancy, antiphospholipid

Front 27

Heparin

Back 27

↑antithrombin II

antidote - protamine sulphate

Front 28

Warfarin

Back 28

↓vit K

antidote - vit K

Front 29

AML

Back 29

Middle aged

Auer rods

Front 30

CML

Back 30

Middle aged

Philadelphia chrom t(9;22)

BCR ABL fusion gene

Front 31

CLL

Back 31

Old

Smear cells

Front 32

ALL

Back 32

Little kids

Front 33

Hodgkins lymphoma

Back 33

EBV assoc

pain post ETOH

REED STERNBERG cells - owl eye

Front 34

Multiple myeloma

Back 34

paraprot IgG

CRAB - ↑Ca, ↓renal, anaemia, bones

BENCE JONES

Front 35

Bence Jones

Back 35

multiple myeloma

Front 36

Reed sternberg

Back 36

Hodgkins lymphoma

Front 37

Auer rods

Back 37

AML

Front 38

Smear cells

Back 38

CLL

Front 39

Philadelphia chrom

(what is it and what is it assoc w/)

Back 39

t(9;22) BCR-ABL fusion gene

CML

Front 40

Fanconi anaemia

Back 40

aut rec, pancytopenia

Front 41

Dyskaratosis congenita

Back 41

↓telmoeres, nails, leukoplakia, BM failure

Front 42

Scwachman Diamond anamia

Back 42

aut rec

NEUTROPHILIA

Front 43

Diamond Blackfan

Back 43

↓RBC only

Front 44

Myelofibrosis

Back 44

Tear drop poikilocytes (dacrocytes)

Front 45

Essential thrombocytosis

Back 45

++megacaryocytes in BM

plt >600, lg plts

Rx: anagrelide (↓plt formation)