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60 Cards in this Set
- Front
- Back
Councilman Bodies: (/acidophil bodies)
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apoptotic, eosinophilic hepatocytes extruded into the sinuses
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Adria cell:
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cardiac myocyte which has lost its cross-striations and myofilaments secondary to Adriamycin toxicity
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Aschoff bodies:
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foci of fibrinoid necrosis within the myocardium of a patient with acute rheumatic fever
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Asteroid bodies
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acidophilic, stellate inclusions in giant cells in sarcoidosis and berylliosis
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Auer Rods
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red-rod shaped lysosomes (abnormal) seen in malignant cells of predominantly M3 acute myelogenous leukemia
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Barr Bodies:
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inactivated X chromosome - dark staining mass in contact with the nuclear membrane
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Birbeck granules:
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“Tennis racket” shaped granules in cytoplasm of Langerhans cells (histiocytosis X) with trilaminar “handle”
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Blue-Blobs:
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atrophy in Pap-smears
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Blue bodies:
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laminated PAS+ iron containing bodies in alveolar macrophages of desquamative interstitial pneumonia
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Call-Exner bodies:
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small gland like “follicles” filled with acidophilic material often seen in ovarian granulosa cell tumors
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Caterpillar cells:
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large multinucleated giant cells with lengthwise chromatin clumping in nucleus; appear owl eyed on cross section; seen in heart in acute rheumatic fever
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Charcot-Leyden crystals:
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crystals shaped like double pyramids; found in sputum of asthma patients; made by eosinophils
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Councilman Bodies:
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apoptotic, eosinophilic hepatocytes extruded into the sinuses
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Corpora Amylacea:
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Represent a degenerative change in astrocytes. Basophilic and PAS positive polyglucosan globules in terminal processes of astrocytes. Number increases with age. Can also be found in nodular hyperplasia of prostate.
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Corpora Arantii:
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small fibrous nodules at the centers of the semilunar valve cusps along the lines of closure
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Cowdry type A inclusions:
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acidophilic intranuclear inclusion separated from the nuclear membrane by an artifactual cleft - typical of Herpes infected cells (HSSV, VZV)
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Curschmann’s spirals:
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twisted mass of mucus seen in sputum of patients with asthma
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Donovan body:
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intracellular bacillus (Calymmatobacterium donovani) seen in histiocytes in the genital skin of patients affected with granuloma inguinale
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Dutcher bodies:
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“intranuclear” inclusions of immunoglobulin in plasmacytoid cells
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Faggot cells:
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malignant promyelocytes of M3 AML containing numerous Auer rods like “sticks in a fireplace”
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Gandy-Gamna bodies:
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calcium and hemosiderin deposits in the spleen: seen in setting of increased hemolysis
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Glomus bodies:
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regulated arteriovenous anastomoses in the skin which play a role in thermoregulation (many in fingers and toes). Glomus tumour can arise. The tumour is bening, but painful, most often seen under nails.
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Guarneri bodies:
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Epidermal cells with eosinophilic cytoplasmic inclusions in skin of patients with smallpox
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Hassall’s corpuscles:
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concentric aggregates of keratinized epithelial cells and keratin in the medulla of the thymus
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Heinz bodies:
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clumps of precipitated oxidized hemoglobin in the cytoplasm of red cells
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Hirano body:
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eosinophilic, football shaped inclusion seen in neurons of the brain; part of normal aging, but more numerous in Alzheimer’s disease
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Hutchinson’s teeth:
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inflammatory destruction of the teeth seen in tertiary syphilis
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Hutchinson’s triad
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Hutchinson’s teeht, keratitis, eight nevre deafness
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Kamino bodies:
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Intraepidermal hyaline globules seen in a Spitz nevus ("benign juvenile melanome", but, it's not a melanoma, and can also occure in adults..old term)
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Kayser-Fleischer rings:
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rings of discoloration on cornea of patients with Wilson’s disease (AR, copper accumulates, symptoms; neurological or psychiatric or liver disease;hepatitis, cirrhosis, necrosis)
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Koplik’s Spots:
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spotty lesions that blister and ulcerate deep in the cheek mucosa; diagnostic for measles
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Lambl’s excrescences:
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small fibrin vegetations overlying sites of endothelial damage of flow side of cardiac valves
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LE bodies (AKA hematoxylin bodies):
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nuclei of damaged cells with bound anti-nuclear antibodies which become homogeneous and loose chromatin pattern. When phagocytosed, form LE cells, Seen in SLE
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Lewy bodies:
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round, concentrically laminated, pale eosinophilic cytoplasmic inclusions seen in neurons in Parkinson’s disease
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Libman-Sacks nodules:
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non-bacterial verrucous cardiac valve leaflet vegetations seen in SLE
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Lipofuscin Granules:
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polymers of lipid complexed with proteins - responsible for brown atrophy
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Lisch Nodules:
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pigmented iris hamartomas seen in patients with type I neurofibromatosis
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Loose Bodies:
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fragments of bone or cartilage which become detached into the joint space; may continue to grow by surface apposition; centers eventually necrose and calcify
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MacCallum’s plaques:
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map-like thickening of the endocardium over myocardial lesions in acute rheumatic fever
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Mallory Bodies:
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alcoholic hyalin - eosinophilic intracytoplasmic inclusions in hepatocytes: intermediate filaments, predominantly prekeratin. Found in alcoholic hepatitis, alcoholic cirrhosis, Wilson's disease, primary-biliary cirrhosis, non-alc cirr, hepatocellular ca., morbid obesity.
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Michaelis-Gutmann bodies:
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partially digested bacteria, (calcified) in stroma and in cells; seen in Malakoplakia ( rare inflammatory condition which makes its presence known as a papule, plaque, ulcers)
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Negri Bodies:
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bullet shaped cytoplasmic inclusions in neurons (especially Purkinje cells); pathognomonic for rabies infection
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Nemaline Bodies:
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Z-bands seen by EM in degenerative skeletal muscle diseases
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Neurofibrillary Tangles:
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microtubule-associated proteins and neurofilaments, seen in Alzheimer’s disease
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Physaliferous cells:
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very large tumor cells with bubbly vacuolated cytoplasm (some glycogen) and vesicular nuclei, seen in chordomas
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Reinke crystalloid:
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crystals found in Leydig cells of testes: hexagonal prisms, tapered ends, moderately electron dense
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Rokitansky’s protuberance:
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central area of an ovarian mature cystic teratomas containing bone and well formed teeth
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Rosenthal fibers:
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intracytoplasmic hyaline structure, sometimes corkscrew shaped, found in pilocytic astrocytes
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Russell Bodies:
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cytoplasmic immunoglobulin (du to overproduction) inclusions in plasma cells or plasmacytoid cells
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Schaumann bodies:
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concentrically laminated inclusions (up to 50µm) in giant cells seen in sarcoidosis and berylliosis
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Schiller-Duval bodies:
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endodermal sinuses: glomeruloid structures seen in yolk sac tumors
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Smudge cell:
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cell with a large, ovoid nucleus filled with granular amphophilic to deeply basophilic mass and an indistinct nuclear membrane; seen in Adenovirus infected cells
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Soldier’s plaque:
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white thickening of the epicardium from a healed pericarditis
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Sulfur Granules:
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yellow foci of Actinomyces
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Sucquet-Hoyer canals:
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shunts of Glomus bodies, involved in thermal regulation
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Verocay bodies:
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palisades of nuclei at the end of a fibrillar bundle in a Schwannoma (Neurilemoma)
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Warthin-Finkeldey cells:
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multinucleated giant cells with eosinophilic nuclear and cytoplasmic inclusions found in lymphoid organs of patients with measles
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Weibel-Palade bodies:
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Rod-shaped cytoplasmic organelles in endothelial cells containing von Willebrand factor
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Zebra Bodies:
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palisaded lamellated membranous cytoplasmic bodies seen by EM in macrophages of patients with Niemann-Pick disease, Tay-Sachs disease, or any of the mucopolysaccharidoses
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Zellballen:
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clusters of tumor cells surrounded by a thin fibrovascular stroma, seen in pheochromocytoma and extra-adrenal paragangliomas
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