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15 Cards in this Set

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Chronic Myeloid Leukemia
-Philadelphia Chromosome in granulocytes
-15% of all leukemia cases in US
-Age of onset 40-50
-Rare in childhood/adolescence
-Acute is more symptomatic
Leukemia
-Circulating tumors
-Involve blood and bone marrow
-Disseminated at beginning of disease
Lymphoma
-Lymph Tissues
-Disseminates to other sites at diagnosis
Myeloid
-RBC's, platelets, monocytes, granulocytes
Lymphoid
T-cells, B-cells, NK cells
Non-Hodgkin's Lymphoma
B-Cell, T-Cell and NK Cell
Hematologic Neoplasms Diagnosis
Leukopenia, Anemia, Thrombocytopenia, Netropenia
Leukopenia
lymphadenopathy, joint swelling and pain, weight loss, anorexia, hepatomegaly, splenomegaly
Anemia
pallor, fatigue, malaise, shortness of breath, decreased activity tolerance
Thrombocytopenia
a platelet count below 20,000 cells/μl, petechiae, easy bruising, bleeding gums, occult hematuria, retinal hemorrhages
Neutropenia
absolute neutrophil count <500 cells/μl
Evaluation of peripheral blood sample key aspect of diagnosis
Definitive diagnosis is usually made after bone marrow aspiration or lymph node biopsy
Chronic Myeloid Leukemia
Fatigue, weight loss, bleeding, splenomegaly, weight loss, sweats
Acute Myeloid Leukemia
80% are adults, age of onset is 64, transformation of myeloid stem cell, bone pain, thrombocytopenia, anemia, similar to ALL, infections at GI, GU, skin, resp. tracts
Acute Lymphoblastic Leukemia/Lymphoma
Lymphoid cell malignancy, 80% b-cell 20% T-cell transofrmation, abnormal lymphoblasts look like immature lymphocytes, mostly children
ALL
most common malignancy, 2nd leading cause of death