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36 Cards in this Set
- Front
- Back
Dx: translocation involving PML1 gene and RAR gene (t(15:17)) which results in encoding of functional RAR allowing maturation of tumor cells
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acute promyelocytic leukemia (APL)
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Frequent presenting disorder of APL
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DIC
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Dx: t(9:22)(q34:q11) with bcr/abl encoding p190
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acute lymphocytic leukemia (ALL)
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neoplasms composed of pre-T or pre-B cells
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acute lymphocytic leukemia (ALL)
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Dx: PAS positive, peroxidase negative, TdT positive, CD 19 and CD 10
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pre-B ALL
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Dx: PAS positive, peroxidase negative, TdT positive, CD 1, 2, 5, 7
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pre-T ALL
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Dx: t(8;21) or inv(16) that encode products that inhibit terminal differentiation
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acute myelogenous leukemia (AML)
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AML classification: blasts lack def cytological markers of myeloblasts (myeloperoxidase neg) but express myeloid lineage antigens
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M0 - min differentiated
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AML classification: very immature, > 3% blasts, peroxidase positive, few granules or Auer rods
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M1 - without differentiation
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AML classification: full range of myeloid maturation through granulocytes, Auer rods present, associated with t(8:21)
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M2 - with maturation
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AML classification: most cells are hypergranular promyelocytes with many Auer rods, associated with t(15:17)
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M3 - APL
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AML classification: myelocytic and monocytic differentiation, monoblasts are pos for nonspecific esterases, associated with inv(16)
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M4 - acute myelomonocytic leukemia
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AML classification: monoblasts and promonocytes predominate in blood
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M5 - acute monocytic leukemia
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AML classification: dysplastic erythroid precursors predominate, >30% myeloblasts
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M6 - acute erythroleukemia
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AML classification: megakaryote blasts predominate, react with Ab against GPIIb/IIIa or vWF, myelofibrosis
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M7 - acute megakaryocytic leukemia
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Dx: staining for CD 33 and 34 is positive
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AML
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Dx: staining for CD 41 and 61 is positive
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AML with megakaryote involvement
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Dx: smudge cells in the PBS
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CLL/SLL
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Dx: expression of CD19, 20, 23 and 5, deletions of 13q, 11q, 12q or 17p
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CLL/SLL
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Dx: t(9:22)(q34:q11) with bcr/abl encoding p210
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CML
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Dx: clonal B cell prolif of sm to med sized lymphocytes, occurs largely in older men
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hairy cell leukemia
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Dx: positive for tartrate-resistant acid phosphatase (TRAP)
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hairy cell leukemia
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Most common type of Hodgkins lymphoma
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nodular schlerosing
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Dx: Reed-Sternberg cells
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Hodgkins lymphoma
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Lyphoma with no leukemic state
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Hodgkins lymphoma
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What is the Ricter transformation?
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change from CLL/SLL to large cell lymphoma
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Dx: IgM spike, hyperviscosity
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Waldenstrom disease (lymphoplasmic lymphoma)
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Dx: cutaneous T cell lymphoma with Pautrier microabscesses
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mycosis fungoides
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Infection with HHV-8 can cause which non-Hodgkins lymphoma?
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diffuse
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Dx: t(8:14) with starry sky appearance
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Burkitt lymphoma
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Dx: t(11:14) with CD 5, 19, 20
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mantle cell NHL
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NHL associated with H pylori infection
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marginal zone
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lymphoma involving plasma cells
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multiple myeloma
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Most common complication of multiple myeloma
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amyloid nephropathy
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Dx: PAS positive hyaline microthrombin with schistocytes in PBS
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TTP
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# of platelets to dx essential thrombocythemia
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>= 600,000
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