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9 Cards in this Set
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MAB drugs
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Mifepristone (progesterone receptor antagonist - detachment of blastocyst) OR Methotrexate (antifolate drug - feticidal action on blastocyst)
Misoprostol - PGE1 - contracts uterus and expels contents AE - N/D, fever COMPS - excessive uterine bleeding, rupture, incomplete AB |
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Tocolysis - delay labor
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Antenatal glucocorticoids
Tocolytic drugs given for up to 48 hrs: Beta 2 agonists: Terbutaline - relaxation by binding beta 2 receptors Ritodrine CI - cardiac dz, poorly controlled hyperthyroidism/DM Calcium Channel Blocker - Nifedipine - relax by decreasing intracellular calcium NSAID - Indomethacin - inhibit COX - relax by decreasing prostaglandin synthesis in uterus AE - to fetus - premature closure of ductus arteriosus |
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Induction and maintenance of labor
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Misoprostol - PGE1
Dinoprostone - PGE2 --> help in ripening cervix and initiating labor; intravaginally Oxytocin - augments uterine contractions AE - water nitoxication due to interaction w/ ADH receptors, excessive uterine contractions, rupture of uterus |
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Postpartum Hemorrhage
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Oxytocin, if doesn't stop bleeding, use Ergonovine IM (partial agonistic effects on 5HT2 to stop and alpha recepters -- sustained contractions to stop uterine bleeding)
CI - HTN, liver/kidney dz, presence of sepsis |
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Category A
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no risk to human fetus
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Category B
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animal studies show no risk, but no studies in people
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Category C
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risks cannot be r/o
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Category D
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positive evidence of human fetal risk but potential benefits from drug use outweigh potential risk
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Category X
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CI in pregnancy; risks outweigh benefits
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