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15 Cards in this Set
- Front
- Back
How is autodigestion prevented in the pancreas? |
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What do alpha, beta and delta cells secrete? |
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Describe pancreatic aplasia. |
Uncommon - seen with other developmental problems. Incompatible with life. |
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Describe pancreatic hypoplasia. |
Rare- calves. Exocrine tissue only. Leads to EPI. |
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Describe pancreatic juvenile atropy. |
Dogs <13mo - GSD, RCC. EPI - weight loss (good appetite), pale faeces, steatorrhoea. Pancreas almost absent although Islets unaffected. No inflammation. |
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What can pancreatitis be caused by? |
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What are symptoms of acute pancreatitis? |
Focal necrosis, h+, thrombosis, oedema, inflammatory infiltrate. Followed by fat necrosis. Eventually results in chronic fibrosing pancreatitis → pan insufficiency and DM |
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What is chronic fibrosing pancreatitis? |
Sequalae of acute necrotising pancreatitis (dogs) or without prior signs (cat). Tissue replaced with fibrous tissue. |
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Describe EPI. |
Exocrine pancreatic insufficiency. >80% of tissue lost. Due to atrophy, chronic pancreatitis or neoplasia. Pale, soft, malodorous, voluminous faeces, high fat content. Malabsorption of vitamins (Fat soluble - ADEK), Dx- trypsin-like immunoreactivity (TLI) assay |
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Describe nodular hyperplasia of pancreas. |
Not true neoplasm. Old dogs, cats, cattle. Multiple, non-encapsulated non-compressive growths |
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Describe adeoma of exo pancreas. |
Rare, solitary |
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Describe adenocarcinoma of exo pancreas. |
Dogs, cats. Originate from acini or ducts. Tissue replaced with grey scirrhous (hard, slow growing) tissue +/- h+, necrosis. Metastasises on peritoneum and diaphram → thorax and liver. Non-specific symptoms due to metastases, ascites common. |
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Describe insulinoma. (B-cell tumour). |
functional B cells. Hyperinsulinism, hypoglycaemia, neuro signs |
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Describe gastrinoma. |
Secrete gastrin → Zollinger-Elison syndrome (xs gastrin) Gastric hypersecretion, hyperacidity, mucosal hyperplasia, ulceration. |
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Describe a glucagonoma. |
A-cell tumour. Hyperglycaemia, diabetes mellitus. |