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26 Cards in this Set

  • Front
  • Back
Abeta fiber
mechanoreceps
Adelta
fast mechano and noci
C fibers
nociceptors, thermoceptors, mechanoceptors
Mechanoceptors
turn on interneuron
slow down pain transmission
LC
locus ceruleus
NRPG
nucleus reticularis paragigantocellularis
PAG
periaquaductal grey cortex
controls ones affective response
can enhance pain response
can attenuate pain
Electrical stimulation cause analgesia
Enkephlin
Put electrodes in PAG with it
cause analgesia
natural body opioid
Naloxone
Opioid recep antagonist
CGRP
Calcitonin gene related peptide
Substance P
most popular pain transmitter
NK1
its release activated Ca2+ inside neuron --> activates number of pathways
NO synthase increased by Ca2+: magnifies stimulus
Norepinephrine
alpha recep located presynap to dec release of pain
located post synap to dec firing rate
Glutamate
PAIN
NMDA and AMDA
Ketamine
blocks NMDA ion channel
NSAID
blocks COX2
Opioids
act on nu, kappa, delta receps
Capsaicin
analgesic yet a pain inducer
depletes substance p!
similar to vanillin
vanilloin receptor
bradykinin
peptide
pain transmitter
injected locally or systemically to induce pain
Seratonin
Seratonin 3 recep
only ION recep
ATP
purinergic recep
H+ ion recept
changes pH
Acid sensing ion channel
Heat
vanilloid recep heat sensing
pressure
epithelium sodium channel recep
substance p
degranulates histamine containing mast cells
Pain receptors are...
in the periphery
CGRP and Serotonin
released locally before signal gets to spinal cord
Pain: reaches spinal cord, antidromic transmission