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259 Cards in this Set

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T/F Most children outgrow regurgitation by 1 year of age
True
Rx of reflux (evidence based)
no Rx required for most children
thickened feeds
PPI for suspected esophagitis
fundoplication if severe
Most common cause of lactose intolerance?
primary lactase deficiency
uncommon < 2 years of age
What is frothy stools in a breastfed infant due to?
relative lactose malabsorption
What weight is allowable to lose in newborn?
10% of birthweight
How much weight gain is expected per week in newborn?
100-200 g/week
What drug can be given to improve breast milk supply?
Motilium (domperidone) - dopamine antagonist
What is the definition of constipation in a newborn?
delay or difficulty passing stool present for >2 weeks
What is the most common cause of constipation in a child?
functional constipation
aka withholding stool to avoid unpleasant defacation
What is Herschsbrung's disease?
failure of normal innervation of the distal colon by the ganglion cells of the myenteric plexus
Signs of Herschsprung's disease
failure of passage of meconium
toxic megacolon
Rx of Herschsprung's disease
colostomy of aganglionic bowel
What is craniosynostosis?
premature fusion of one or more cranial sutures
(palpable ridging over fused suture, compensatory overgrowth of other sutures)
What percentage of ARIs are viral in kids?
What are the common pathogens?
90%
Rhinovirus
RSV
Parainfluenzae 1, 2, 3
Influenza
Adenovirus
Most common cause of bronchiolitis
RSV
Rx of bronchiolitis
supportive - oxygen if low sats
bronchodilator not effective, but hard to distinguish patients who are asthmatic
When is bronchiolitis most common?
< 1 years, most common between 2 weeks and 9 months
What causes 75% of Croup cases?
Parainfluenza 1, 2, 3
When is the peak incidence of croup?
2nd year of life
Rx for Croup
mild: prednisilone or dexamethsone
if severe, adrenaline and dexamethasone
Cause of epiglottitis
HiB
Signs of epiglottitis
cherry red swollen epiglottis
drooling
minimal cough
Rx of epiglottitis
Manage airway
Antibiotics - ceftriaxone
What is the most common cause of anaphylaxis in children?
peanuts
T/F Most children do not outgrow their food allergies
True
T/F IgE sensitisation correlates with clinical atopy
False
T/F RAST tests are superior to skin prick testing for diagnosis of IgE sensitisation
False
What is the most significant risk factor for allergies in children?
family history
Do skin prick tests have negative and positive predictive values?
over 2 years, good negative predictive value
fair positive predictive value when combined with history
Does size of reaction in skin tests correlate with severity of reaction in atopy
No
What percentage of allergies present in the first year of life?
80%
Contraindications to skin prick testing?
severe eczema
have taken anti-histamine
(can still do RAST if taken anti-histamine)
Length of time of IgE mediated reaction
< 2 hours
if 2-4 hours, think non-IgE mediated food allergy
Effect of burns on circulation
local --> edema
general --> hypovolemia
Effect of burns on metabolism
anabolic hormones decreased: growth hormone, thyroxine, anabolic steroids
catabolic hormones increased: glucagon, cortisol, catecholamines
What is the zone necrosis?
central area of the burn
does not become viable ever again
What is zone of stasis?
progressive necrosis if not resuscitated within 26-48 hours
What is zone of hyperemia?
outermost area of burn
will always be viable
First aid for burns
ABC
run under cool water for 30 minutes
do not use ice
What is the rule of 9s for burns in children?
Head: 18%
Body: 18% front, 18% back
Arms: 9% each
Legs: 14% each
One hand: 1%
Difference between superficial and deep thickness burns
Superficial: red, painful
partial thickness superficial: painful
partial thickness deep: painless,
full thickness: painless, white, charred
Rx of full thickness burns
wound contraction or skin grafting
Formula for fluid resus in paeds for burns (1st 24 hours)
3-4 ml X % BSA affected X wt in kg
run first 1/2 in 1st 8 hours, 2nd 1/2 over 16 hours
Hartmann's solution
Rx for inhalation burns
give oxygen, maybe hyperbaric if severe
Criteria for outpatient treatment
2-5%: outpatient
on trunk or limbs, not over joints, not circumferential
Safe transport to burns unit
<6 hours, clean burn: saline + plastic wrap
>6 hours, dirty burn: chlorhex + acticoat
Features of lung abscess on xray
air-fluid levels
round density
opaque rim
What bacteria causes lung abscesses?
Anaerobic bacteria
occasionally staph aureus and klebsiella
Treatment of lung abscess
antibiotics
ampicillin + beta lactamase inhibitor (augmentin)
Biomechanical differences in bone between adults and paeds
1. ligaments are stronger than growth plate --> epiphyseal separation, less likely for sprains/dislocations
2. young bone more porous --> most plastic/deformation
What is a buckle fracture? What is a greenstick fracture?
Buckle: has a fracture on one side and bend on the other
Greenstick: no fracture on one side and bend on the other
When do you not expect remodelling in bone?
1. intra-articular fractures
2. diaphysis fractures w gross angulation, shortening, rotation
3. fractures w/ deformity at right angles to plane of joint mvmt
T/F Speed of healing is slower in children
False
Tell me about Salter Harris fractures
S: straight - thru physis (growth plate)
A: above - metaphysis AND growth plate
L: low - thru epiphysis and growth plate
T: thru and thru - thru epihysis AND metaphysis
R: ram - crush
What special extra xrays do you need in kids?
joint above and below
How soon after injury do you need to perform surgery in an open fracture in kids?
w/in 6 hours
Clinical presentation of pulled elbow
aka subluxation of radial head
refusal to use arm
pronated forearm
pain with supination
passive ROM normal
Treatment of pulled elbow
flex and supinate
if doesn't get better, reconsider dx
rest if unsuccessful
What does fat pad sign indicate?
in trauma, marker of fracture
Up until what age is having a >38 degree temperature a red flag (requires admission to hospital)?
up to 3 months
What are clinical features of intussception?
abdo pain - knees up to chest
episodic abdo pain - 2-3x per day
red currant jelly stool
vomiting - predominant feature
sausage shaped mass
diarrhoea is quite common
At what age does intussception present?
6-18 months
What signs are seen on imaging for intussception?
target sign - telescoping
crescent sign - crescent lucency in left upper quadrant w soft tissue mass
Management of intussception
1. NG tube
2. ABs
3. air enema
What is seen on ultrasound in pyloric stenosis
thickened elongated pylorus
What are the electrolytes in pyloric stenosis
hypokalemia
hypochloremia
alkalosis
Risk factors for pyloric stenosis
male
maternal family history
Signs of pyloric stenosis
presents 2-4 weeks
bilious projectile vomiting
olive sign
constipation
dehydration
Management of pyloric stenosis
Ramstedt pyloromyotomy
not urgent, do surgery after electrolyte balance
At what age do babies smile?
6 weeks
incubation period for pertussis
10-14 days
symptoms show after 2-3 days of coryza
What is the bacteria that causes pertussis?
gram negative, gram positive
bordetella pertussis, gram neg
T/F pediatric cancers are sensitive to chemotherapy
true
What is the commonest childhood malignancy?
ALL
Lab features of ALL and AML
anemia (Hb 50-60)
thrombocytopenia
neutropenia
+/- circulating blasts
What age is a poor prognosis in ALL
<12 months
Good prognostic factors in ALL
age 2 - 10
lower WCC
prednisone response
no CNS disease
hyperdiploidy
B-precursor
t (12;21)
Why is leukocytosis bad in AML
high viscosity --> high risk of intracranial bleeding
What site is the most common solid tumor in kids?
brain
Where are brain tumors more likely to develop in kids?
posterior fossa
What is a neuroblastoma?
tumors of adrenal gland or of sympathetic trunks deriving from primitive neural crest cells
most are abdominal in adrenal gland or sympathetic chain
poor prognosis, most present with metastatic disease
What gene is associated with neuroblastoma?
N-MYC oncogene
Classic presentation of neuroblastoma
pale, irritable
reluctant to walk (bony mets)
periorbital ecchymoses
What investigation assists in dx neuroblastoma
urinary catecholamines
What is a Wilm's tumor?
nephroblastoma
What are the clinical features of a Wilm's tumor?
80% asymptomatic, unilateral painless abdominal mass
hematuria
mets to lung and liver
Management of Wilm's tumor
nephrectomy
Which virus is associated with Hodgkin's lymphoma
EBV
What is the mainstay treatment for Hodgkin's lymphoma?
chemotherapy
also can do radiotherapy
What is a common cause of intussception
lymphoma
What is elevated in tumor lysis syndrome
LDH
Which cell is involved in Burkitt's lymphoma - B or T
B
What is Ewing's sarcoma?
bone tumor that affects diaphysis and axial skeleton
Which chromosomal translocation is involved in Ewing's sarcoma?
11;22
How does Ewing's sarcoma present?
pathological fracture
met disease
Xray of Ewing's sarcoma
moth-eaten pattern often accompanied by onion-skin periosteal reaction
When do bone sarcomas usually present?
teenagers, during growth spurt
Where does osteosarcomas present?
growing end of long bones
most common distal femur, proximal tibia and proximal humerus
What is the most common soft tissue sarcoma? Where does it usually occur?
rhabdomyosarcoma, genitourinary
How does rhabdomyosarcoma usually present?
firm, painless mass
What are the complications of measles?
* encephalitis: typically occurs 1-2 weeks following the onset of the illness)
* subacute sclerosing panencephalitis: very rare, may present 5-10 years following the illness
* febrile convulsions
* pneumonia, tracheitis
* keratoconjunctivitis, corneal ulceration
* diarrhoea
* increased incidence of appendicitis
* myocarditis
How many primary teeth do humans have? How many permanent?
20, 32
When do primary teeth erupt? When are primary teeth completely erupted?
6 months, 2 years old
Rx of mild acute asthma attack
mild = >60% PEF, wheeze
6 (<20 kg) or 12 (>20kg) puffs of salbutamol
if it's been going on for a few days - oral prednisolone
Rx of moderate acute asthma attack
mod = PEF 40-60%, O2 92-95%
6 or 12 puffs of salbutamol every 20 minutes for 1 hr
oral pred for 3 days
Rx for severe acute asthma attack
severe = PEF <40%, unable to speak, O2 <92%
6 or 12 puffs of salbutamol, every 20 minutes for 1 hr
iptratropium
oral pred
Rx of critical acute asthma attack
nebulized salbutamol
nebulized ipratropium
IV methylpred
magnesium sulphate
aminophylline - if very sick
When do you do chest xray in asthma attack?
mild-mod: only if focal signs present
severe: only if no response to initial therapy or pneumothorax
when can you discharge asthma pts in regards to salbutamol timing?
if taking salbutamol every 3 hourly or less, they can go home
What is infrequent intermittent asthma? How do you Rx?
exacerbation every 4-6 weeks
Rx w salbutamol
What is frequent intermittent asthma?
How do you treat?
exacerbation 2x / month
Rx w salbutamol, then add montelukast, sodium cromoglycate, or nedocromyl sodium
if no effective, give inhaled CS
What is persistent asthma? How do you treat?
>2 exacerbations/month
Rx with salbutamol, inhaled CS, then add LABA
6 step asthma management plan
1. assess severity
2. achieve best lung fxn
3. maintain best lung fxn - triggers
4. " - meds
5. make a management plan
6. educate and review
At what age can you use a puffer?
> 6 years old
What is the asthma first aid plan?
1. give 4 puffs of reliever, 4 breaths in between
2. wait 4 minutes
3. repeat
4. if no improvement, call ambo
What PEF is considered life threatening in asthma?
<33%
Difference between measles and roseola infantum
measles: unwell, fever and rash together, confluent lesions
roseola: child is well, fever falls with rash, rash mainly on trunk, discrete lesions
When are children with varicella infectious?
48 hours before rash until lesions crust (usually 3-7 days after rash shows up)
Where is the varicella rash predominantly?
truncal
Most common complication of varicella?
superinfection with GAS and staph aureus
What type of vaccine is varicella?
live attenuated, wildtype strain
Rx of varicella in kids
supportive, pain relief
only if immunocompromised, give acyclovir
How does shingles usually present in the immunocompromised child?
disseminated disease - pneumonitis, hepatitis, brain
Which virus seen in childhood affects the gumlines?
Herpes simplex virus
What is the commonest cause of hand, foot and mouth disease?
Coxsackie 16
Which enterovirus is associated with most severe hand, foot and mouth disease?
enterovirus 71
What is impetigo?
bacterial skin infection, typically on face, can get on top of insect bites/abrasions, most common organism is staph aureus, not painful, very contagious, rx w topical chlorhexidene +/- ABs
Complications of measles
at time: otitis media, sinusitis, bronchopneumonia, croup, encephalitis, myocarditis
later: subacute sclerosing panencephalitis
Rx of measles
supportive
How is rubella rash different from measles?
measles = peeling
rubella = develops more quickly, disappears more quickly
Features of Scarlet fever
4Ss: sore throat, strawberry tongue, sandpaper rash, perioral sparing
3Ps: non pruritic, non painful, peeling
What is scarlet fever caused by?
GAS
What are the complications of scarlet fever?
GN and rheumatic fever
What is Kawasaki disease?
acute febrile vasculitis of childhood common in Asians
1-8 years old
Fever for 5 days + 4/5 criteria
1. bilateral conjuctival injection
2. oral changes - red mouth, cracked lips
3. swelling of hands and feet
4. cervical lymphadenopathy
5. rash
Complications of Kawasaki disease
vasculitic complications: myocarditis, thrombi
BIG risk of coronary artery aneurysms - urgent treatment as soon as they present to avoid getting them
Investigations in Kawasaki disease
echo
Rx for Kawasaki disease
aspirin (6-8 weeks) and Ig
screen for coronary artery disease
Clinical features of Parvovirus B19 (erythema infectiosum)
slapped cheek, 1-2 weeks later lacy maculopapular rash on arms and legs
What causes erythema infectiosum
Parvovirus B19
Clinical features of meningococcal infection
petechial, or purpuric non blanching rash
two major clinical presentations: meningitis or septicemia
fever, vomiting, headache, neck stiffness
Rx of meningococcal disease
Im penicillin in GP's office
at hospital, 3rd generation cephalosporin
What is gower's manoeuvre?
indicates weakness of proximal mm
patient must use his hands and arms to "walk" up his own body from a sitting position due to lack of hip and thigh mm strength
What is spinal muscular atrophy?
Degeneration of the anterior horn cells in the spinal cord and motor nuclei in the brainstem
4 types
autosomal recessive
What is spinal muscular atrophy type 1?
Most common and severe type
Most infants die before one year of age due to respirator failure
Marked proximal weakness
Decreased movement
Bell shpaed chest
Tongue fasciculations
absent reflexes
What is spinal muscular atrophy type 2?
Presents later in life
Do gain ability to sit but can't stand unsupported
Charcot marie tooth?
DISTAL MM weakness
Hereditary
Mutation in myelin gene --> defects in myelin structure, and formation
Features: motor and sensory nerve problems, distal leg weakness, foot deformities (pez cavus, hammer toes)
Early complaints - sprained ankles
What do the nerve conduction studies show in Carcot marie tooth?
Severe slowing of conduction in both motor and sensory < 60%
Are nerve conduction studies /electromyography normal or abnormal in spinal muscular atrophy?
Nerve conduction studies are normal
Electromyography is abnormal
T/F Adolescents require less sleep than kids
True
T/F Adolescents have a tendency to fall asleep and wake later in the day
True
T/F Adolescents have marked reduction in slow wave sleep
True - less restorative sleep
What is the most common sleep problem in adolescence?
poor sleep hygiene
What type of genetic mutation is muscular dystrophy?
X-linked recessive
Genetic pattern in muscular dystrophy
1/3 spontaneous mutations
rest are x-linked recessive
Pathophysiology of muscular dystrophy
missing dystrophin --> mm fibers become fragile and breakdown
Clinical features of muscular dystrophy
proxial mm weakness by age 3
decreased reflexes
hypertrophy of calf mm
wasting of thigh mm
delayed motor and cognitive development
cardiomyopathy
respiratory insufficiency
die between 20-30
Treatment of muscular dystrophy
supportive
corticosteroids
What is difference between Duchenne and Becker muscular dystrophy
X-linked defect in dystrophin gene
Becker = defect is not complete, similar to Duchenne but onset is later and progression is slower
Classic red flag of purpuric rash and bulging fontanelle means...
meningitis
Classic red flag of high pitched scream means...
increased ICP/child abuse
Classic red flag of biphasic stridor means...
complete airway obstruction
Classic red flag of bile stained vomiting means...
bowel obstruction
Difference between decorticate and decerebrate posturing
decorticate (flexion): suggests lesion above the brainstem
decerebrate (extension): suggests lesion below the brainstem
What is a very effective measure of circulation on physical exam?
capillary refill
What is the number of nappies in reduced urine output?
<4 in 24 hours
Most common cause of gastroenteritis
rotavirus
2nd most common: astrovirus
3rd: norwalk
At what % dehdyration do you get tachycardia? dry mucous membranes?
5%
At what % dehydration do you get sunken eyes and fontanelle, reduced skin turgor?
7-9%
T/F Capillary refill has been shown to correlate with degree of dehydration
True
Is rice oral rehydration better than standard rehydration?
no, there is no difference
Which is the recommended rehydration solution? oral or iv?
oral
What is the rehydration formula and when do you give it?
5 x 10 x wt in kg --> over 24 hours

given when 5% dehydrated
In fluids, what is the bolus dose and when do you give it?
10-20 mL/kg

given when >10% dehydration
Which fluids do you give for maintenance, rehydration, bolus?
bolus = Hartmann's or normal saline
the rest are N/2

NEVER give N/4!
How much potassium do you give in rehydration?
3 mmol/kg/24hrs
What fluid do you use in hypernatremic dehydration?
N/2 + 2.5% dextrose
What is the most common organism in otitis externa?
fungal
bacterial: pseudomonas or staph
Treatment of otitis externa
sofradex, ciprooxin
What is the ductus venosus?
connection between umbilical vein and IVC
What takes oxygenated blood from the placenta to the baby? vein or artery?
vein - 1
Which fetal shunt closes first after birth? Why?
PFO
Increase in LA pressure secondary to increase in pulmonary blood flow and pulmonary venous return
At what day does PDA start to close? completely close? why?
Starts closing within 10-15 hours
Closes permanently within 2-3 weeks
Why? increase in PaO2, decreased prostaglandin
When does ductus venosus start to close? why?
Right after birth
takes 3-7 days
why? Probably passive due to reduced flow and pressure
Which ventricle is dominant in neonates?
RV
This dominance slowly diminshes through childhood
Most common congenital heart disease?
VSD
Features of an innocent murmur?
systolic
ejection
musical
grade 1-3 (no palpable thrill)
changes with body position
varies with review (augmented by illness)
What feature will be found on a normal newborn ECG?
RAD
What is the most common cyanotic heart defect?
tetraology of fallot
What are the 4 features of tetralogy of fallot?
RVH
Overiding position of aorta
VSD
RVOTO - pulmonary stenosis
What determines severity of Tetralogy of Fallot?
right ventricular outflow stenosis
Management of Tetralogy of Fallot
surgery within 2 years of life
Murmur heard in Tetralogy of Fallot
harsh ejection systolic
Murmur heard in VSD
systolic at left sternal base
Murmur heard in ASD
ejection systolic murmur
female:male ratio in DDH
6:1
Imaging for DDH
<6 months U/S
>6 months xray
Rx for DDH
<6 months: closed reduction, put in brace, frog leg

6-12 months: try closed, if no success --> open

>12 months: open reduction, brace

>18 months: acetabuloplasty
Irritable hip DDx based on age
2-5 years: transient synovitis
4-10 years: Perthe's
10-15 years: Slipped capital femoral epiphysis
Presentation of Perthe's disease
limp
+ Trendelenberg sign
limited hip abduction
What is the bad outcome of Perthe's disease and slipped femoral epiphysis?
> 50 % get Osteoarthritis by age 40 (50 for slipped epiphysis)
Rx of slipped capital epiphysis
surgical emergency!
Most common form of juvenile idiopathic arthritis
oligarthritis </=4 joints (50%)
>5 joint (30%)
What is the commonest vasculitis in childhood?
HSP

peak incidence: 4-10 years
What size vessels does HSP affect?
small
Criteria for HSP
must have 2/4:
1. palpable purpura
2. <20 years
3. bowel angina
4. granulocytes in walls of arterioles or venules w/ biopsy
DO you want a higher or a lower uring output in kids cf adults
higher urine output
Toddlers - 1.5ml/kg/hr
< 1 year 2ml/kd/hr
Rx of HSP
NSAIDs
severe abdo pain may warrant steroids

recurrence risk is 30%
Heart rate values in pediatric patients
up to 1 year: 100-170
slowly goes to adult values at age 12
RR values in pediatric patients
Maximums
newborn: 60
1 yr: 40
2 yr: 30
5 yr: 20
BP systolic values in pediatric patients
newborn: 50
1 yr: 90
2 yr: 100
5 yr: 110
>12 yrs: 120
What is impetigo?
skin disorder caused Staph aureus and GAS --> blister with vesicle/pustule, usually<2 cm, with honey colored plaque/crust

mimics tinea
Rx of impetigo
swab with chlorhex
oral ABs for 7-10 days
What causes dermatophyte folliculitis? Rx?
fungus

Rx w gruseifulvin
topical ABs won't work!
What is tinea caused by? What does it look like?
dermatophytes - fungi

annular, central clearing rash like, pruritic on skin, hair, nails
Difference between eczema and tinea
tinea is unilateral
Rx of tinea
anti-fungals for 6 weeks, griseofulvin
What is molluscum contagiosum caused by?
pox virus

acquired thru direct contact - pools, tubs, family bath tub
Which eye reflex is the first to be developed? When does it appear
Following reflex
first week of life
Which eye infections are common 0-2 months?
Opthalmia neonatorum
leukocorya
retinopathy of prematurity
wandering eyes
Which infections are common 3months - 3y
watery eye - nasolacrimal duct, congenital glaucoma
Red eyes and lids - conjunctivities, cellulitis
Leukocorya
Strabismus
Injury
What is epiphora?
watery eyes
What is congenital nasolacrimal duct obstruction?
mucocele of the lacrimal sac
presents with epiphora and d/c
What are causes of a watery eye (epiphora)
nasolacrimal duct obstruction
congenital glaucoma
corneal irritation from foreign body or lashes
Management of NL duct obstruction?
massage over lacrimal sac
bathe with saline
probe and irrigate if not resolved by 1 year
What are the most common causes of neonatal conjunctivitis?
Onset day 1 gonoccoal
Staph 4-5 days of life
Onset day 10 - chlamydia
How does neonatal conjunctivitis present?
swollen red eyes and eyelids
Mucopurulent dc
When are the peri-auricular lymph nodes enlarged in neonatal conjunctivits?
viral
DO you use steroid eye drops in herpes simplex keratitis?
NO you can get corneal scarring
What do you see in herpes simplex keratitis with fluorescein?
dendritic ulcer
looks like branching tree
Treatment of strabismus?
Cover good eye
Kick that bad eye into gear
What is strabismus?
Misalignment of the eyes, squint
What is amblyopia?
lazy eye
= unilateral strabismus
What is leukocoria?
white pupil
What are the 2 causes of leukocoria?
retinoblastoma
congenital cataract
What is retinoblatoma?
intraocular malignancy - cancer of retina (therefore no red reflex)
sporadic or genetic
associated with chromosome 13
bilateral in 25%
How might a retinoblastoma present?
leukocoria
strabsmus
secondary glaucoma
uveitis
How do you manage congenital cataract?
aphakic spectacles
contact lens correction
can do surgery if bilateral and complete
How do you tell the difference between orbital and preseptal cellulitis?
if eye is pushed forward it is orbital i.e. proptosis
Do you admit a child with preseptal or orbital cellulitis?
YES
What are small cysts on the eyelid of a child and how do you treat them?
Meibomina glands - acute infection
treat with heat, topical/systemic antibiotics, incise and curette under GA
At what age do children walk, sit unsupported, babble?
Walk - 18 months
Sit unsupported 9 months
babble - 6 months
what gives you a machinery murmour?
PDA
How do you treat a strawberry naevus?
= large red thing on face
leave it alone, it will go away by itself, the only time you take it off is if it's obstructing something like vision
What is a machinery murmur associated with?
PDA
Incidence of VUR
up to 20%

70% of kids with UTI have VUR
Ix in UTI
> 6 months and typical: no imaging, AB prophlyaxis not indicated in first

> 6 months and recurrent: U/S w/in 6 weeks, consider DMSA scan

<6 months: do U/S within 6 weeks

<6 months and recurrent: U/S during infection and follow up with screening
What is a DTPA scan?
functional scan - shows blood flow and obstruction
What is a DMSA?
demonstrates scarring in the kidneys

done 4-6 months after infection in atypical or recurrent UTI
What is MCUG?
detects VUR

shows anatomical detail of bladder and urethra

done if family hx, dilatation on U/S, poor urine flow, non E Coli
Rx for UTI
if young (1-6 months) and unwell: gent + benpen (or ampicillin)

if well: oral bactrim or cephalexin
What is not likely to be minimal change disease in nephrotic syndrome?
1. renal impairment
2. significant HTN
3. age <1 year >10 years
4. macroscopic or persistent microscopic hematuria
5. red cell casts in the urine
6. family hx of nephrotic syndrome
7. syndromic child
8. steroid resistance
T/F Cow's milk is a good source of iron
false, it has none!
Commonest cause of chronic neutropenia
autoimmune neutropenia of infancy
Rx of AI neutropenia infancy
benign, will get better by 4 yo
give ABs if infection
Blood test AML
high WCC and differentials
low Hb and platelets
Rx of AML
chemo
fluids to combat viscosity
platelets so no hemorrhage
Blood film in G6PD deficiency
low Hb,
high retics
high WCC, neutrophils
high total bilirubin (due to hemolysis)

blood film: bite and blister cells
is G6PD deficiency x-linked? recessive or dominant?
X- linked autosomal recessive
What are blood tests in ALL
pancytopenia