Ota - Pharmacology - Opioid And Non-Opioid Analgesics

Front 1

Which of the following statements is correct?
- Pethidine is an opioid antagonist
- Naloxone is an opioid antagonist
- Naltrexone is an opioid antagonist
- Phenacetin is an opioid antagonist

Back 1

Which of the following statements is correct?
- Naloxone is an opioid antagonist+
- Naltrexone is an opioid antagonist+

Front 2

Which of the following statements is correct?
- Tramadol is a strong opioid
- Tramadol is a non-opioid
- Tramadol is a weak opioid
- Tramadol is an inhibitor of reuptake of serotonin a noradrenaline

Back 2

Which of the following statements is correct?
- Tramadol is a weak opioid+
- Tramadol is an inhibitor of reuptake of serotonin a noradrenaline+

Front 3

Which of the following statements is/are correct?
- nausea and vomiting are common adverse effects of opioids
- constipation is a common adverse effect of opioids
- peptic ulcer is a common adverse effect of opioids
- dependence is a common adverse effect of treatment with opioids

Back 3

Which of the following statements is/are correct?
- nausea and vomiting are common adverse effects of opioids+
- constipation is a common adverse effect of opioids+

Front 4

Which of the following statements is correct?
- Paracetamol (acetaminophen) in overdose produces hepatotoxicity
- Paracetamol (acetaminophen) in overdose produces metabolic acidosis
- Paracetamol (acetaminophen) in overdose produces liver failure
- Paracetamol (acetaminophen) in overdose produces Reye´s syndrome

Back 4

Which of the following statements is correct?
- Paracetamol (acetaminophen) in overdose produces hepatotoxicity+
- Paracetamol (acetaminophen) in overdose produces liver failure+

Front 5

Which of the following statements is/are correct?
- death by overdose with strong opioids is caused by excessive hypertension
- death by overdose with strong opioids is caused by gastrointestinal bleeding
- death by overdose with strong opioids is caused by inhibition of respiration+
- death by overdose with strong opioids can be prevented by naloxone+

Back 5

Which of the following statements is/are correct?
- death by overdose with strong opioids is caused by inhibition of respiration+
- death by overdose with strong opioids can be prevented by naloxone+

Front 6

Which of the following statements is/are correct?
- COX-2 selective NSAIDs have the advantage of a rapid onset of analgesic action
- COX-2 selective NSAIDs have the advantage of a lower risk of gastropathy
- COX-2 selective NSAIDs have the advantage of a lower risk of bleeding
- COX-2 selective NSAIDs have the advantage of a lower cardiovascular risk

Back 6

Which of the following statements is/are correct?
- COX-2 selective NSAIDs have the advantage of a rapid onset of analgesic action
- COX-2 selective NSAIDs have the advantage of a lower risk of gastropathy+
- COX-2 selective NSAIDs have the advantage of a lower risk of bleeding+
- COX-2 selective NSAIDs have the advantage of a lower cardiovascular risk

Front 7

Which of the following statements is/are correct?
- Ibuprofen produces an irreversible inhibition of platelet cyclooxygenase
- Aspirin produces an irreversible inhibition of platelet cyclooxygenase
- Diclofenac lacks an antiinflammatory effects
- Paracetamol (acetaminophen) lacks an antiinflammatory effects

Back 7

Which of the following statements is/are correct?
- Aspirin produces an irreversible inhibition of platelet cyclooxygenase+
- Paracetamol (acetaminophen) lacks an antiinflammatory effects+

Front 8

Which of the following statements is/are correct?
- in patients with painful bony metastases oral morphine may be used
- in patients with painful bony metastases a combination of an opioid with a non-steroidal anti-inflammatory drug (NSAID) could be beneficial
- opioids do not produce important adverse effects in patients with painful bony metastases
- in patients with painful bony metastases carbamazepine may have better analgesic effects than opioids

Back 8

Which of the following statements is/are correct?
- in patients with painful bony metastases oral morphine may be used+
- in patients with painful bony metastases a combination of an opioid with a non-steroidal anti-inflammatory drug (NSAID) could be beneficial+

Front 9

Which of the following statements is/are correct?
- Opioids are used therapeutically as analgesics
- opioids are used therapeutically as antidepressants
- opioids are used therapeutically as sedatives
- opioids are used therapeutically as anti-diarrheals

Back 9

Which of the following statements is/are correct?
- Opioids are used therapeutically as analgesics+
- opioids are used therapeutically as anti-diarrheals+

Front 10

Which of the following statements is/are correct?
- Naloxone has a low affinity for mu receptors
- Naloxone is effective only by the parenteral route+
- Naloxone has a significantly longer half-life than morphine
- Naloxone acts by competitive inhibition+

Back 10

Which of the following statements is/are correct?
- Naloxone is effective only by the parenteral route+
- Naloxone acts by competitive inhibition+

Front 11

Which of the following statements is/are correct?
- antiplatelet effect of aspirin is caused by inhibiting the production of prostacyclin
- antiplatelet effect of aspirin is caused by inhibiting the production of thromboxane
- hepatotoxicity caused by paracetamol overdose can be antagonized by acetylcysteine
- hepatotoxicity caused by paracetamol overdose can be antagonized by atropine

Back 11

Which of the following statements is/are correct?
- antiplatelet effect of aspirin is caused by inhibiting the production of thromboxane+
- hepatotoxicity caused by paracetamol overdose can be antagonized by acetylcysteine+

Front 12

Which of the following statements is/are correct?
- the risk of gastrointestinal bleeding after NSAIDs is higher in infants
- the risk of gastrointestinal bleeding after NSAIDs is higher in diabetes
- the risk of gastrointestinal bleeding after NSAIDs is higher in elderly (>65 years)
- the risk of gastrointestinal bleeding after NSAIDs is higher in ulcer disease

Back 12

Which of the following statements is/are correct?
- the risk of gastrointestinal bleeding after NSAIDs is higher in elderly (>65 years)+
- the risk of gastrointestinal bleeding after NSAIDs is higher in ulcer disease+

Front 13

Which of the following statements is/are correct?
- Aspirin is contraindicated in children with chickenpox or flu symptoms
- Aspirin is contraindicated in peptic ulcer disease
- Aspirin is the drug of choice for rheumatoid arthritis
- Aspirin should be avoided in diabetics

Back 13

Which of the following statements is/are correct?
- Aspirin is contraindicated in children with chickenpox or flu symptoms+
- Aspirin is contraindicated in peptic ulcer disease+

Front 14

Which of the following statements regarding opioid analgesics is/are correct?
- pain relief provided by opioids increases with age
- the combination with paracetamol increases their analgesic efficacy
- opioid analgesics should never be given to patients with chronic pain
- in acute pain, the risk of inducing opioid-dependence is negligible

Back 14

Which of the following statements regarding opioid analgesics is/are correct?
- the combination with paracetamol increases their analgesic efficacy+
- in acute pain, the risk of inducing opioid-dependence is negligible+

Front 15

Which of the following NSAIDs is/are COX-2 selective?
- celecoxib
- ibuprofen
- etoricoxib
- aspirin

Back 15

Which of the following NSAIDs is/are COX-2 selective?
- celecoxib+
- etoricoxib+

Front 16

Common adverse effects of opioids are:
- nausea and vomiting+
- constipation+
- peptic ulcer
- thrombocytopenia

Back 16

Common adverse effects of opioids are:
- nausea and vomiting+
- constipation+

Front 17

Which of the following drugs inhibits platelet cyclooxygenase?
- aspirin
- tramadol
- ibuprofen
- warfarin

Back 17

Which of the following drugs inhibits platelet cyclooxygenase?
- aspirin+
- ibuprofen+