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38 Cards in this Set

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(this lesion does not rub off)
see below for differential diagnoses
PRACTICE TESTS: (determine your differential list in the allotted time and modify your
differential list based on the "patient" history)
1) GIVE 8 DIFFERENTIALS IN 2 MINUTES (patient does not smoke or use beetle nuts)
2) GIVE 6 DIFFERENTIALS IN 1MIN 30SEC (THIS LESION IS NOT HEREDITARY)
Leukoedema – can leukoedema really look like this?
White sponge nevus
Chronic hyperplastic candidiasis
surgical scar – this DD is a stretch; it would be a weird scar (could be scars from aphthous major)
frictional keratosis
plaque lichen planus – take out this DD because it looks a lot more like reticular LP
reticular lichen planus
lichenoid drug reaction
lupus erythematosus Isn't this considered a red/vascular lesion??
- lupus can cause annular leukoplakia areas, erythematous erosions and chronic ulcerations
(according to book)
snuff dipper's leukoplakia
oral submucous fibrosis
squamous cell carcinoma
Additional Suggested Differential Diagnoses (add here if you think of any):
Graft versus host disease (Dr. C considers GVHD to be erosive)
Idiopathic leukoplakia
Chronic ulcerative stomatitis (autoimmune) - (Dr. C considers this to be erosive)
Contact stomatitis from cinnamon or amalgam (allergic)
Erosive lichen planus (autoimmune) (Dr. C considers this to be erosive)
(long term ulcer)
see below for differential diagnoses
PRACTICE TEST: (determine your differential list in the allotted time and modify your
differential list based on the "patient" history)
1) GIVE 8 DIFFERENTIALS IN 2 MINUTES (NEGATIVE FOR FUNGAL IN
(long term ulcer)
1) GIVE 8 DIFFERENTIALS IN 2 MINUTES (NEGATIVE FOR FUNGAL INFECTIONS)
Chancre (primary syphilis): Isn't this short term ulcer? No.
Gonorrhea
Tuberculosis
Actinomycosis
North American Blastomycosis
Cryptococcosis
Histoplasmosis
Coccidioidomycosis-
Chronic traumatic ulcer
Aphthous major
Lupus erythematosus
Squamous cell carcinoma
Carcinoma-in-situ
Behcet's Syndrome
Additional Suggested Differential Diagnoses (add here if you think of any):
nectrotizing sialometaplasia (pg 341 in book, most common at soft/hard palate junction, can also
occur on tongue, retromolar pad) - Dr. C wants us to only consider it a palatal lesion
Secondary syphilis mucus patch "Remember folks, it's a bacteria and not a viiiiirus, duh."
Tertiary syphilis (gumma)
Lymphoma: Non-Hodgkins: Note that Hodgkin's lymphoma rarely identifies in the soft tissue of
oral cavity unless it's in stage 4 widely disseminated
Instant ID
Nevus of Ota
1) GIVE 6 DIFFERENTIALS IN 1MIN 30SECS
1) GIVE 6 DIFFERENTIALS IN 1MIN 30SECS
Hereditary hemorrhagic telangiectasia
Infectious mononucleosis
Measles (paramyxovirus) - no, I think Dr. C is considering measles to cause vesicular lesions
- palatal petechiae are an additional symptom of measles (besides the vesicular lesions)
Scarlet fever (streptococcus pyogenes)
URI
Suction
Trauma
Scurvey
Thrombocytopenia, examples:
Idiopathic thrombocytopenic purpura
Autoimmune thrombocytopenic purpura
chemotherapy induced thrombocytopenia
Leukemia
Additional Suggested Differential Diagnoses (add here if you think of any):
hemophilia
GIVE 5 DIFFERENTIALS IN 1 MINUTE 15 SECONDS
GIVE 5 DIFFERENTIALS IN 1 MINUTE 15 SECONDS
focal fibrous hyperplasia
pyogenic granuloma
peripheral giant cell granuloma
peripheral ossifying fibroma
peripheral odontogenic fibroma
focal hyperplastic gingivitis
fibrosarcoma
Additional Suggested Differential Diagnoses (add here if you think of any):
Capillary hemangioma - maybe
Traumatic Neuroma
Granulation Tissue- can resemble pyogenic granuloma
Malignant fibrous histiocytoma
Neurofibroma
Neurilemmoma
Instant ID
Instant ID
median rhomboid glossitis
DDx
Acinic cell carcinoma (this is the actual diagnosis)
Adenoid cystic carcinoma
Mucoepidermoid carcinoma
Pleomorphic adenoma
Papillary cystadenoma lymphomatosum
Oncocytoma
Malignant mixed cell tumor
Additional Suggested Differential Diagnoses (add here if you think of any):
Hemangioma
Hodgkin and Non-Hodgkin Lymphoma - just a guess
GIVE TWO LISTS OF DIFFERENTIALS:
1) Consider these to be short term ulcers (GIVE 4 DIFFERENTIALS IN 1 MINUTE)
2) Consider these to be ulcers that were originally vesicular lesions that have already ruptured
(GIVE 4 DIFFERENTIALS IN 1 MIN)
GIVE TWO LISTS OF DIFFERENTIALS:
1) Consider these to be short term ulcers (GIVE 4 DIFFERENTIALS IN 1 MINUTE)
2) Consider these to be ulcers that were originally vesicular lesions that have already ruptured
(GIVE 4 DIFFERENTIALS IN 1 MIN)
1) short term ulcers
Cyclic neutropenia
Acute trauma
erythema multiforme
Pyostomatitis vegetans
Aphthous minor
Proposed differential diagnoses and comments (in italics)
2) uclers that were originally vesicular lesions
Recurrent intraoral herpes
Acute primary herpetic gingivostomatitis
Herpangina
Measles (koplik spots)
Herpes zoster (chicken pox)
Try to list 1 hereditary condition, 2 infectious conditions and 4 neoplasms IN 1 MINUTE 45
SECONDS
Try to list 1 hereditary condition, 2 infectious conditions and 4 neoplasms IN 1 MINUTE 45 SECONDS
Cervical lymphoepithelial cyst
Non-specific lymphadenitis
Tuberculosis infection
Cat scratch fever infection
Cysticercosis
Carotid body tumor
Metastatic carcinoma
Hodgkin lymphoma
Non-Hodgkin lymphoma
Lymphangioma
Nasopharyngeal carcinoma
Additional Suggested Differential Diagnoses (add here if you think of any):
Submandibular gland sialadenitis (according to OMFS textbook)
Sarcoidosis (according to OMFS textbook)
Plunging ranula (according to OMFS textbook)
DECIDE what category you think this lesion belongs to BEFORE scrolling to the bottom :)
DDx
DECIDE what category you think this lesion belongs to first.
- I thought of this as an ulcerated lesion –
Gumma (tertiary syphilis)
Tuberculosis
Actinomycosis
Histoplasmosis
North American Blastomycosis
Coccidioidomycosis
Cryptococcosis
Chronic traumatic ulcer
Squamous cell carcinoma
IF THIS WAS A "red lesion," then here are some potential differentials. BUT, What else
could it be?
Erythroplakia
Instant ID
Instant ID
xanthelasma
TRY TO LIST 8 differentials IN TWO MINUTES and only have 3 neoplasms
TRY TO LIST 8 differentials IN TWO MINUTES and only have 3 neoplasms
Proposed differential diagnoses (add comments in italics):
Polycystic disease of the parotid
Non-specific parotitis (example from book: after abdominal surgery)
Cytomegalovirus infection
Cysticercosis
Epidemic parotitis (mumps) - not sure about this one; I think mumps is more generalized
Obstructive sialolithiasis
Sialadenosis - not sure about this one because I don't know what this looks like; is it more
generalized?
Amyloidosis
Sarcoidosis
Pleomorphic adenoma
Monomorphic adenoma (more likely basal cell adenoma variant)
Papillary cystadenoma lymphomatosum
Oncocytoma
Mucoepidermoid carcinoma
Adenoid cystic carcinoma
Acinic cell carcinoma
Malignant mixed tumor
Additional Suggested Differential Diagnoses (add here if you think of any):
Polymorphous Low Grade Adenocarcinoma? - this generally occurs in minor salivary glands and
rarely arises in major glands.
DDx
Proposed differential diagnoses (add comments in italics):
Ludwig's angina
Cysticercosis
Dermoid cyst
Ranula
Mucous retention cyst
Obstructive sialolithiasis in sublingual gland
Chronic sclerosing sialadenitis
Pleomorphic adenoma- but more likely to see this in Parotid? yes
Oncocytoma
Adenoid cystic carcinoma
Osseous and cartilaginous choristoma
Additional suggested differentials (list any that you can think of):
Oral lymphoepithelial cyst - not sure about this one for this particular lesion
PRACTICE TESTS: (determine your differential list in the allotted time and modify your
differential list based on the "patient" history)
1) GIVE 5 DIFFERENTIALS IN 1 MINUTE and 15 SECONDS (this male patient does not have
a history of seizures)
1) GIVE 5 DIFFERENTIALS IN 1 MINUTE and 15 SECONDS (this male patient does not have a history of seizures)
Proposed differential diagnoses (add comments in italics):
Hereditary gingival fibromatosis
Idiopathic gingival hyperplasia
Non-specific hyperplastic gingivitis
Plaque induced gingivitis - would likely be more red than this
Puberty induced gingival hyperplasia
Pregnancy induced gingival hyperplasia
Diabetes induced gingival hyperplasia
Drug induced gingival hyperplasia (cyclosporin, nifedipine, phenytoin- also verapamil, primidone)
Leukemia - would likely be more red than this
Multiple irritation fibromas (focal fibrous hyperplasia) - just a guess
Additional suggested differentials:
PRACTICE TEST: Patient Hx ELIMINATES pregnancy induced gingival hyperplasia and phenytoin induced hyperplasia
Proposed differential diagnoses (add comments in italics):
Hemangioma
Ecchymosis
Lupus erythematosus
Erythroplakia
Squamous cell carcinoma
Idiopathic
Additional suggested differentials:
granulation tissue?
Instant ID
Sturge-Weber
bonus points: Encephalotrigeminal angiomatosis
DDx
Remember: decide what category it is in first :)
DDx
Remember: decide what category it is in first :)
Epidermolysis bullosa
Erythema multiforme
Pemphigus vulgaris
Mucous membrane pemphigoid
- Oral mucous membrane pemphigoid
- Bullous pemphigoid
- Cicatricial pemphigoid
Erosive lichen planus
Graft versus host disease
Chronic ulcerative stomatitis
Lupus erythematosus
Instant ID
Instant ID
melasma
DDx
DDx
Ephelis
Actinic lentigo
Lentigo simplex
Cafe-au-lait spot
Junctional nevus
Other suggested differentials:
Compound nevus
Interdermal nevus
Melanotic macule; This only occurs in the mouth. The equivalent on the skin is the ephelis
DDx
DDx
Neuroma of MEN IIB
Lingual thyroid nodule - on Dr. C's list, but not sure if it would look like this. Also this is located
at the posterior tongue.
Oral lymphoepithelial cyst
Cysticercosis
Amyloid nodule
Neurilemoma
Granular cell tumor
Leiomyoma
Rhabdomyoma
Mucoepidermoid carcinoma
Other suggested differentials:
Most mesenchymal bumps and lumps can appear on the tongue (as mentioned in class) except for lipoma and osteoma. He mentioned that he will narrow some of the lumps and bumps out by giving us hints in the question.
DDx
DDx
Physiologic pigmentation
Smoker's melanosis
Addison's disease
Post-inflammatory hyperpigmentation
Drug related hyperpigmentation due to AZT, anti-malarial drugs, minocycline
Instant ID
Instant ID
mongolian spot
DDx
DDx
Cysticercosis
Dental abscess
Traumatic neuroma
Kaposi sarcoma
Burkitt lymphoma
Pleomorphic adenoma
Mucoepidermoid carcinoma
Adenoid cystic carcinoma
Polymorphous low grade adenocarcinoma
Other suggested differentials:
exostoses
Basically any lesion that has fibrous tissue, nuerons, and blood vessels can be put in this differential:
angioma/angiosarcoma
neurofibroma solitary
fibrosarcoma, etc.
Multiple neurofibromatosis
Cysticercosis
Focal fibrous hyperplasia (irritation fibroma)
Mucocele - doesn't really look like it, but fits the category. I agree...
Mucous retention cyst
Fibroma
Neurofibroma
Lipoma/Liposarcoma
Leiomyoma/Leiomyosarcoma
Rhabdomyoma/Rhabdomyosarcoma
Mucoepidermoid carcinoma
Polymorphous low grade adenocarcinoma

Other suggested differentials:
I originally thought of this as a papillary lesion BUT many people have thought of this as a lump. My initial instinct was that it was an irritation fibroma, which I thought was a papillary lesion. BUT, papillary lesions are actually "papillary" according to Dr. C because of their histological traits. So, now I think this is a LUMP/BUMP category. Thanks for the clarification from many astute members of our class :) Very helpful :)
Instant ID
Instant ID
cafe au lait spots with some ephelides
White sponge nevus
Chronic hyperplastic candidiasis
Frictional keratosis
Surgical scar/graft
Oral submucous fibrosis (usually on gingiva only?) - no, it usually affects soft tissues of buccal mucosa, lips, soft palate, and occasionally the pharynx
Lichenoid drug reaction
Plaque lichen planus
Idiopathic Leukoplakia
Squamous cell carcinoma
Other suggested differentials (list any that you think of):
Did anyone see this as a papillary lesion? Something resembling Proliferative verrucous leukplakia? Can someone clarify?
Parts of it DO look like it could be papillary, if something like this comes up, he'll hopefully
guide us in one direction or another. : )
(This lesion has been present for more than 3 weeks)
DDx
(This lesion has been present for more than 3 weeks)
DDx
Tertiary syphillis - gumma
Tuberculosis infection associated ulcer
Actinomycosis infection associated ulcer
Gonorrhea associated ulcer
Deep fungal infection
- North American Blastomycosis
- Histoplasmosis
- Cryptococcosis
- Coccidioidomycosis
Necrotizing sialometaplasia
Chronic traumatic ulcer - finger nail trauma (Factitious injury)
Burkitt lymphoma
Non-hodgkin lymphoma
Mucoepidermoid carcinoma
Adenoid cystic carcinoma
Squamous cell carcinoma
Other suggested differentials (list any that you think of):
Primary and second syphillis - not sure if these can be on the palate
Agranulocytosis
Instant ID
Instant ID
pterygium
DDx
DDx
Polycystic disease
Epidemic parotitis
Bacterial parotitis (ex. after an abdominal surgery [according to the book])
CMV infection
Obstructive sialolithiasis
Sialadenosis (obesity, bulimia, alcoholism, diabetes)
Sjogren Syndrome
Pleomorphic adenoma
Malignant mixed tumor
Monomorphic adenoma (basal cell adenoma variant)
Mucoepidermoid carcinoma
Adenoid cystic carcinoma
Acinic cell carcinoma
Papillary cystadenoma lymphomatosum
Oncocytoma
(this does not rub off)
(this does not rub off)
Leukoedema
White sponge nevus
Chronic hyperplastic candidiasis - could be
Surgical scar/graft
Oral submucous fibrosis
Snuff dipper's leukoplakia
Lichenoid drug reaction - maybe?
Plaque lichen planus
Idiopathic leukoplakia
Other suggested differentials:
Nicotine stomatitis? - only on the palate
Patient has a white lesion that rubs off.
DDx
Patient has a white lesion that rubs off.
DDx
Acute pseudomembranous candidiasis
Bacterial mucous patch
Materia alba
Chemical burn from mouth wash, denture paste
Aspirin burn
Radiation mucositis
Collapsed bullae - not likely
(please focus on the most obvious and largest lesion)
DDx
(please focus on the most obvious and largest lesion)
DDx
Atrophic candidiasis
Radiation mucositis
Xerostomia
Lichenoid mucositis (ex. lichenoid drug reaction)
Allergy
Erythroplakia
Squamous cell carcinoma
Other suggested differentials:
Ecchymoses
DDx
DDx
Inflammatory papillary hyperplasia
Condyloma acuminatum
Squamous papilloma
Verruca vulgaris
Focal epithelial hyperplasia
Other suggested differentials:
Nicotine stomatits? it's a white lesion that doesn't rub off but it's supposed to have papules too.
CASE: Patient reports no recollection of how long he has had this single, nodular lesion. Patient has never eaten raw pork.
GIVE 6 differentials in 1.5 minutes :)
CASE: Patient reports no recollection of how long he has had this single, nodular lesion. Patient has never eaten raw pork.
GIVE 6 differentials in 1.5 minutes :)
Oral lymphoepithelial cyst
Amyloid nodule
Dermoid cyst
Lipoma/Liposarcoma
Leiomyoma/Leiomyosarcoma
Rhabdomyoma/Rhabdomyosarcoma
Solitary fibrous tumor
Neurofibroma
Osseous and cartilaginous choristoma
Other suggested differentials:
Cysticercosis (ruled out by the patient history)
Ranula?
LIST 5 differentials in 1 minute and 15 seconds...
LIST 5 differentials in 1 minute and 15 seconds...
Thyroglossal tract/duct cyst
Cysticercosis
Goiter
Hashimoto's thyroiditis
Graves disease
Thyroid cancer (ex. papillary carcinoma, medullary)
Dermoid cyst
LIST 6 differentials and only three of them can be neoplasms
LIST 6 differentials and only three of them can be neoplasms
Cervical lymphoepithelial cyst
Non-specific lymphadenitis (ex. from a dental infection)
Tuberculosis infection
Cat scratch fever infection
Cysticercosis
Carotid body tumor
Metastatic carcinoma
Hodgkin lymphoma
Non-Hodgkin lymphoma
Lymphangioma
Nasopharyngeal carcinoma
Lipoma/liposarcoma
Rhabdomyoma/Rhabdomyosarcoma
Leiomyoma/Leiomyosarcoma
Other suggested differentials:
Branchial cleft cyst
Non-specific lymphadenitis
Patient also has multiple bullae in the contralateral vestibule. Lesions in right vestibule, left vestibule (not shown) and lip mucosa are related.
DDx
Patient also has multiple bullae in the contralateral vestibule. Lesions in right vestibule, left vestibule (not shown) and lip mucosa are related.
DDx
Epidermolysis bullosa
Mucous membrane pemphigoid
- Oral mucous membrane pemphigoid
- Cicatricial pemphigoid
- Bullous pemphigoid
Pemphigus vulgaris
Chronic ulcerative stomatitis
Graft versus host disease
Erythema multiforme
Erosive lichen planus
Other suggested differentials:
Lichenoid Drug Rxn?
Pt chief complaint: "Woof woof!"
Pt chief complaint: "Woof woof!"
Cervical lymphoepithelial cyst
Non-specific lymphadenitis (ex. from a dental infection)
Tuberculosis infection
Cat scratch fever infection-got owned by cat
Cysticercosis
Carotid body tumor
Metastatic carcinoma
Hodgkin lymphoma
Non-Hodgkin lymphoma
Lymphangioma
Nasopharyngeal carcinoma
Lipoma/liposarcoma
Rhabdomyoma/Rhabdomyosarcoma
Leiomyoma/Leiomyosarcoma
Other suggested differentials:
Branchial cleft cyst this is the same as lymphoepithelial cyst
Non-specific lymphadenitis