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38 Cards in this Set
- Front
- Back
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What are the three opioid receptors?
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Mu
Kappa Delta |
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What receptors do opioid analgesics activate?
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Mu with weak Kappa
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Mu receptors produce _____.
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Analgesia, Euphoria, Sedation, and Physical Dependance
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Kappa receptors produce ___.
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Analgesia and sedation
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What are agonist-antagonist opioids?
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Produce analgesia
Can antagonize analgesia produced by pure opioid |
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What is the prototype strong opioid analgesic?
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Morphine
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Morphine is a ____.
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Strong opioid analgesic
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How does morphine work?
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Mimicking the actions of endogenous opioid peptides
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What are the adverse reactions of morphine?
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Respiratory Depression
Constipation Orthostatic Hypotension Urinary Retention Emesis Elevation of Intra cranial Pressure Miosis (Pupillary constriction) Sedation Cough Supression |
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Cross-tolerance exists among the opioid agonists
T or F |
True
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Is the withdrawal syndrome from opioids dangerous?
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No
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What is Fentanyl?
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Strong opioid analgesic
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What is the prototype drug for mild to moderate pain?
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Codeine
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Codeine is a _____.
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Mild to Moderate opioid analgesic
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Oxycodone is similar in action to _____.
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Codeine
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Agonist-Antagonist Opioids have a (high/low) potential for abuse, produce (more/less) respiratory depression, and are (more/less) powerful.
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low
less less |
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Pentazocine is a ____.
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Agonist-Antagonist opioid
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What is the prototype for the agonist-antagonist opioids?
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Pentazocine
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Pentazocine is a antagonist at ___ receptors.
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mu
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How is it possible to avoid withdrawal syndromes?
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Withdrawal of opioid slowly
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Physical Dependence is the same as addiction.
T or F |
False
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What is a PCA?
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Patient-controlled analgesia
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What is the opioid of choice for obstetric use?
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Meperidine (strong opioid analgesic)
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What is the prototype for opioid antagonists?
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Naloxone
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Physical Dependence is the same as addiction.
T or F |
False
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What is Naloxone?
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Opioid antagonist
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What is a PCA?
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Patient-controlled analgesia
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Tramadol is a ____.
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Non-opioid centrally acting analgesic
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What is the opioid of choice for obstetric use?
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Meperidine (strong opioid analgesic)
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What is the prototype for opioid antagonists?
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Naloxone
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What are the actions of Tramadol?
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Weak agonist at mu receptors
Blocks uptake of NE and 5-HT |
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What is Naloxone?
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Opioid antagonist
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Clonidine is a _____.
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Alpha 2 agonist
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Tramadol is a ____.
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Non-opioid centrally acting analgesic
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Clonidine is used for pain relief.
T or F |
True
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What are the actions of Tramadol?
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Weak agonist at mu receptors
Blocks uptake of NE and 5-HT |
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Clonidine is a _____.
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Alpha 2 agonist
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Clonidine is used for pain relief.
T or F |
True
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