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31 Cards in this Set
- Front
- Back
Disease caused by excess ergot alkaloids
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St. Anthony's fire
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Endogenous substances commonly interpreted as histamine, serotonin, prostaglandins, and vasoactive peptides
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autocoids
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Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; ass'd with severe peptic ulceration and diarrhea
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Zollinger-Ellison Syndrome
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Drug that causes contraction of the uterus
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Oxytocin
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Distribution of histamine receptors H1, H2, and H3
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Smooth muscle; stomach, heart, and mast cells; nerve endings, CNS respectively
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Prototype antagonist of H1 and H2 receptors
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diphenhydramine and cimetridine, respectively
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1st generation antihistamine that is highly sedating
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diphenhydramine
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1st generation antihistamine that is least sedating
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chlorpheniramine or cyclizine
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2nd generation antihistamines
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fexofenadine, loratadine, and cetirizine
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Generation of antihistamine that has the most CNS effects
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first generation due to being more lipid soluble
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Major indication for H1 receptor antagonist
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use IgE mediated allergic reaction
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Antihistamine that can be used for anxiety and insomnia and is not addictive
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hydroxyzine (Atarax)
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H1 antagonist used in motion sickness
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Dimenhydrinate, meclizine, and other 1st generation
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Most common side effect of 1st generation antihistamines
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sedation
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Lethal arrhythmias resulting from concurrent therapy with azole fungals (metabolized by CYP3A4) and these antihistamines which inhibit 3A4 iso-enzyme
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terfenadine and astemizole (removed from market)
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H2 blocker that causes the most interactions with other drugs
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cimetidine
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Clinical use for H2 blockers
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acid reflux disease, duodenal ulcer and PUD
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Receptors for serotonin (5HT-1) are located
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Mostly in the brain, mediating synaptic inhibition via increased K+ conductance
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5HT-1d agonist used for migraine headaches
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Sumatriptan, naratriptan, rizatriptan
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Triptan available in parenteral and nasal formuation
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sumatriptan
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H1 blocker that is also a serotonin antagonist
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cyproheptadine
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Agents for reduction of postpartum bleeding
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oxytocin, ergonovine and ergotamine
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Agents used in treatment of carcinoid tumor
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ketanserin, crproheptadine, phenoxybenzamine
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5HT-3 antagonist used in chemotherapeutic induced emesis
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ondansetron, granisetron, dolasetron and alosetron
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5-HT3 antagonist that has been associated with QRS and QTc prolongation and should not be used in patients with heart disease
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Dolasetron
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DOC to treat chemo-induced nausea and vomiting
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Odansetron
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Drug used in ergot alkaloid OD, ischemia, and gangrene
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Nitroprusside
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Reason ergot alkaloids are contraindicated in pregnancy
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Uterine contractions
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SE of ergot alkaloids
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hallucinations resembling psychosis
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Ergot alkaloid used as an illicit drug
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LSD
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Dopamine agonist used in hyperprolactinemia
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Bromocriptine
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