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21 Cards in this Set
- Front
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Dronabinol (Marinol/Syndros) capsules/solution |
antiemetic Cannabiniods MUST BE REFRIDGERATEd C-III somnolence, euphoria, increased appetite contains 50% EtOH |
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Which of the following statements are true regarding extravasation of chemotherapy? (Select ALL that apply.) A) Cold compresses should be used for all agents except vinca alkaloids and etoposide. B) Warm compresses should be used for all agents except vinca alkaloids and etoposide. C) Dexrazoxane can be used for anthracycline extravasation. D) Extravasation is the leakage of the drug from a vein into the extravascular space. E) Glucarpidase can be used for extravasation from irinotecan. |
A) Cold compresses should be used for all agents except vinca alkaloids and etoposide. C) Dexrazoxane can be used for anthracycline extravasation. D) Extravasation is the leakage of the drug from a vein into the extravascular space. (For Vinca alkaloids use: Hyaluronidase) |
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Definition of Neutropenia |
Neutropenia <1000 Severe Neutropenia <500 Profound Neutropenia <100 normal ranges: 2200-8000 |
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MT is a 62 year-old female (64 inches, 71 kg) who has breast cancer and just completed cycle 2 of her AC regimen today. She had developed neutropenia after her first cycle of AC. Her labs 7 days after her first cycle of AC were: WBC 1,200 cells/mm^3, 30% segs and 2% bands. A dose of Neulasta is ordered to be administered tomorrow. Which of the following statements regarding granulocyte colony stimulating factors (G-CSFs) is NOT correct?
A) G-CSF is used to shorten the duration of neutropenia after chemotherapy. B) Bone pain is a common side effect of filgrastim and pegfilgrastim. C) The branded tbo-filgrastim product is called Granix. D) The branded pegfilgrastim product is called Leukine. E) Zarxio is a bioequivalent filgrastim product. |
Answer is D Pegfilgrastim brand is Neulasta Sargramostim brand is Leukine |
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Ppx for prevention of nephrotoxicity w/ Cisplatin? |
Amifostine (ethyol) |
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Ppx to prevent cardiomyopathy and Tx of extravasation w/ Doxorubicin? |
Dexrazoxane (Zinecard) cardiomyopathy Dexrazoxance (Totect) |
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Given w/ Fluorouracil to enhance efficacy? |
Leucovorin or Levoleucovorin (Fusilev) |
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Tx of severe life-threatening or early onset of toxicity w/ 5-FU or capecitabine? Within how many hours of any overdose? |
Uridine Triacetate 96 hours |
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Ppx to prevent hemorrhagic cystitis of Ifosfamide? |
Mesna (Mesnex) |
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Ppx to prevent acute diarrhea w/ Irinotecan? |
Atropine |
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Given after MTX to reduce myelosuppression and mucositis |
(Levo-)Leucovorin (Fusilev) |
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Given in acute renal failure or high conc. of MTX? |
Glucarpidase (Vorxaze) |
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DC is a 44 year-old female with a history of motion sickness who has experienced debilitating nausea and vomiting with her last chemotherapy cycle. She currently complains of "feeling bloated." She is due to receive the same regimen again. What are the risk factors for high emetogenic? |
Female Age < 50 years Dehydration History of motion sickness, and prior nausea Vomiting with previous chemotherapy regimen are risk factors for CINV (feeling bloated is not a risk factor) |
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What are the anti-emetic regimens that are recommended for highly emetogenic chemotherapy? |
Olanzapine + dexamethasone + palonosetron Azynzeo + dexamethasone Fosaprepitant + dexamethasone + ondansetron |
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What is the advantage in using darbepoetin over epoetin alfa? |
Darbepoetin can be given less frequently than epoetin alfa. ESAs will not work properly if iron stores are not adequate. |
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What conditions need to be met for the addition of epoetin alfa to be appropriate to stimulate red blood cell production in a patient with cancer? |
If used in patients with cancer The provider must be enrolled in the ESA APPRISE program Hemoglobin should be < 10 g/dL Patient should be symptomatic Iron stores adequate. |
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In cancer patients, erythropoiesis-stimulating agents are rarely used to treat anemia due to which of the following concerns: |
Shortened survival Increased tumor progression have limited the use of ESAs in cancer patients Cancer patients must meet the requirements of the ESA APPRISE Oncology Program (a REMS program) before receiving ESA treatment. |
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What is the recommended maximum lifetime cumulative dose of doxorubicin? |
550 mg/m2 |
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Which of the following statements is/are correct regarding prochlorperazine? |
This drug can cause pseudo-parkinsonism. This drug can cause significant QT prolongation. This drug can cause strong anticholinergic side effects. Prochlorperazine (Compro, Compazine) is a dopamine receptor antagonist. |
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ST is a 44 year-old female (Ht. 5'5" Wt. 48 kg, BSA 1.5 m^2) who is receiving the following chemotherapy regimen for breast cancer. She will not be undergoing any radiation as part of her treatment. Doxorubicin 60 mg/m^2 IV on day 1 Cyclophosphamide 600 mg/m^2 on day 1 Zofran 16 mg IV prior to chemotherapy Dexamethasone 20 mg IV prior to chemotherapy Repeat cycles every 21 days for 4 cycles Question: What is the recommended maximum lifetime cumulative dose of doxorubicin for this patient? |
The maximum lifetime cumulative dose of doxorubicin for ST is 825 mg (550 mg/m^2 x 1.5 m^2). |
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Which of the following chemotherapeutic medications is associated with the highest incidence of hand-foot syndrome? A) Doxil B)Ellence C)Avastin D)Adriamycin E)Camptosar |
Doxil Doxil and Lipodox50 are liposomal formulations of doxorubicin. These are associated with more hand-foot syndrome than the non-liposomal formulations. |
