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34 Cards in this Set
- Front
- Back
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alkylating agents?
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busulfan (Myleran)
cyclophosphamide (Cytooxan) ifosfamide (Ifex) |
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platinum analogues?
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carboplatin (Paraplatin)
cisplatin (Platinol) |
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SE of cyclophosphamide?
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hemorrhagic cystitis: dose-related, due to formation of acrolein to prevent give mesna (binds to acrolein) and hydrate
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Use of cyclophosphamide?
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neoplastic (RA, glomerular nephritis, idiopathic thrombocytopenic purpura) and non-neoplastic (breast, ovarian, prostate, lung)
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SEs of oncology drugs?
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CNS2, GI2, BMS- R, W, T, some alopecia, mucusitis, entagenic
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what can ifosfamide (Ifex) cause?
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acrolein metabolite, so give MESNA and hydrate
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SEs of ifosfamide (Ifex)
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hemorrhagic cystitis
CNS2: once experience CNS toxicity (lethargy, fatigue), d/c drug |
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antibiotic for oncology
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bleomycin (SE: pulmonary fibrosis)
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SE: pulmonary fibrosis
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bleomycin
busulfan amiodarone nitrofurantoin |
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SE: cisplatin
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nephro and ototoxicity (like aminoglycosides), prevent with hydration and amifostine
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anthracyclines:
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daunorubicin (Cerbidine)
doxorubicin (Adriamycin) idarubicin (Idamycin) |
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Cerbidine
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daunorubicin
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Idamycin
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idarubicin
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Adriamycin
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doxorubicin
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Myleran
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busulfan
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Cytoxan
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cyclophosphamide
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SE of anthracycline:
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cardiac toxic: give Zenicard (desrazasone)
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use of anthracycline:
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breast, ovarian, leukemias
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lifetime dose of daunorubicin, doxorubicin:
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550mg/m2
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lifetime max dose of idarubicin:
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137.5 mg/m2
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dose of daunorubicin (Cerbidine):
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60 mg/m2
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dose of doxorubicin (Adriamycin)
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12 mg/m2
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desrazoxane
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used to prevent cardiotoxcitiy in pts on anthracyclines
Zinecard |
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antimetabolites
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methotrexate (Amethopterin)
cytarabine (Cytosar) (Ara-C) |
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high dose of methotrexate?
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1 g/m2
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uses of methotrexate:
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solid tumors, lymphomas, RA, psoriasis
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give what with MTX?
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leucovorin- if not mucosal damage in GI tract and irrerversible BMS- R, W
dose: 10-100 mg/m2 q6h until MTX levels fall |
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MTX will cause:
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irreversible BMS: R, W if no leucovorin rescue along with GI mucosal damage
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SE of cytarabine (Cytosar):
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conjunctivits : will need corticosteroid eye drops
CNS1: slurring, forgetfulness |
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most likely to cause mucositis:
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MTX, Ara-C (cytarbine), 5-FU, anthracyclines, bleomycin
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highly ematogenic 60-100%:
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cisplatin, cyclophosphamide, Ara-C (cytarabine), MTX: give 5-HT3 antagonist
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moderately ematogenic 10-60%
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anthracyclines, carbaplatin: can give Reglan and dexamethasone
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low ematogenic <10%:
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bleomycin, busulfan, low dose MTX: give Phenergan and go up from there
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MOA of Zofran
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selectively antagonizes 5HT-3 receptors
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