Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
7 Cards in this Set
- Front
- Back
|
causes of Leukemia (6 main groups) |
1. radiation 2. chemical: benzene, alkylating agents/ topoisomerase inhibs. 3. hereditary (downs 1/95, bloomrs, fanconi, ataxia telangiectasia) 4. hematologic disorders (MDS and MPD's) 5. virus: HTLV-1 6. oncogene: t(8;14) leading to activing of c-myc gene |
|
|
burkitt's lymphoma : genetic basis |
t(8;14) leading to activation of c-myc gene
|
|
|
how does anemia present? wrt CBC 1. which cytopenias? 2. which cells high? 3. resulting sx? |
Progressive cytopenias: anemia, thrombocytopenia, neutropenia (fatigue, bleed, infection progressive leukocytosis ->Leukostasis--> stroke, confusion -> rapid cell turnover: tumor lysis and gout -> sanctuary sites: testes |
|
|
other presentations of leukemia |
pictured: leukemia cutis, monocytic leukemia infiltrating gums, granulocytic sarcoma behind eye |
|
|
Note: complication of acute promyelocytic leukemia? |
DIC Tx = ATRA (all trans retinoic acid, arsenic, chemotherapy?) |
|
|
Pathology differences between ALL and AML |
|
|
|
other differences between ALL and AML adults/children duration of tx CNS risk Sanctuary sites disease free survival |
|
