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114 Cards in this Set

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bethanechol
direct-acting
parasympathomimetic
resistent to Cholinesterases
carbachol
direct-acting
parasympathomimetic
resistent to Cholinesterases
pilocarpine
direct-acting
parasympathomimetic
resistent to Cholinesterases
enters CNS
edrophonium
indirect-acting parasympathomimetic (Anticholinesterase - blocks hydrolysis)
reversible inhibitor
quaternary alcohol strx
neostigmine
indirect-acting parasympathomimetic (Anticholinesterase - blocks hydrolysis)
reversible inhibitor
carbamate ester strx
physostigmine
indirect-acting parasympathomimetic (Anticholinesterase - blocks hydrolysis)
reversible inhibitor
carbamate ester strx
enters CNS: *Tx for atropine toxicity*
isofluorophate
indirect-acting parasympathomimetic (Anticholinesterase)
Irreversible inhibitor
atropine
parasympatholytic (muscarinic blocker)
enters CNS (can cause toxicity)
tropicamide
parasympatholytic (muscarinic blocker)
epinephrine
direct-acting, non-selective sympathomimetic
norepinephrine
direct-acting, non-selective sympathomimetic
phenylephrine
sympathomimetic
direct-acting, selective α1 agonist
clonidine
sympathomimetic
direct-acting, selective α2 agonist
centrally acting
dopamine/dobutamine
sympathomimetic
direct-acting, selective β1 agonist
albuterol
sympathomimetic
direct-acting, selective β2 agonist

used in asthma
pseudephedrine
indirect-acting sympathomimetic (stimulates release of NE)
amphetamine
indirect-acting sympathomimetic (stimulates release of NE & reuptake inhibitor of NE/dopamine)
Cocaine
indirect-acting sympathomimetic (reuptake inhibitor)
phentolamine
sympatholytic
non-selective α blocker
prazosin
sympatholytic
selective α1 blocker
peripherally acting
propranolol
sympatholytic
non-selective β blocker
timolol
sympatholytic
non-selective β blocker

decreases IOP and AH production
metoprolol
sympatholytic
selective β1 blocker
quinidine
anti-arrhythmia
Na+ channel blocker

decreases excitability @ ectopic site
lidocaine
anti-arrhythmia, anesthetic
Na+ channel blocker
amiodarone
anti-arrhythmia
K+ channel blocker

slows repolarization, increases refractory period and decreases abnormal automaticity
sotalol
anti-arrhythmia
K+ channel blocker

slows repolarization, increases refractory period and decreases abnormal automaticity
verapamil
anti-arrythmia, anti-HTN
Ca2+ channel blocker

decrease intracellular Ca2+, decreases contracton, SA rate and AV conduction
diltiazem
anti-arrythmia, anti-HTN
Ca2+ channel blocker

decrease intracellular Ca2+, decreases contracton, SA rate and AV conduction
thiazides
heart failure
diuretic

fx at DCT, decreases K+
furosemide
heart failure
loop diuretic

decreases K+
captopril
heart failure
ACE inhibitor
losartan
heart failure
AT-II receptor type 1 blocker
digoxin
heart failure
Na+/K+/ATPase blocker

weak + inotrope - increases intracellular Na+ and Ca2+ = increased contractility
hydralazine
heart failure
vasodilator (increases NO)
nitrates
anti angina
vasodilators
sildenafil
erectile dysfunction

inhibits PDE-5 causing increased [cGMP] and increase in blood flow to corpus cavernosa
Iron (ferrous sulphate)
anemia
folic acid
anemia
Vitamin B12
anemia
erythropoietin
anemia
cholestyramine
anti-hyperlipidemia
Resin

binds to/prevents reabsorption of bile acids
lovastatin
anti-hyperlipidemia
inhibits hepatic synthesis of cholesterol via inhibition of HMG-Co-A Reductase
simvastatin
anti-hyperlipidemia
inhibits hepatic synthesis of cholesterol via inhibition of HMG-Co-A Reductase
niacin
anti-hyperlipidemia
VLDL secretion inhibitor
gemfibrozil
anti-hyperlipidemia
stimulates lipoprotein lipase

decreases VLDL and increases HDL
fenofibrate
anti-hyperlipidemia
stimulates lipoprotein lipase

decreases VLDL and increases HDL
ezetimibe
anti-hyperlipidemia
inhibits intestinal sterol absorption (targets NPC1L1)
vitamin K
hemorrhagic disease
factor VIII, factor IX(?)
hemorrhagic disease
desmopressin acetate
hemorrhagic disease
aminocaproic acid
hemorrhagic disease
tranexamic acid
hemorrhagic disease
heparin
thromboembolic disease
dicoumarol
thromboembolic disease
warfarin
thromboembolic disease
aspirin
thromboembolic disease, NSAID

↓ COX-1 and COX-2 = ↓ PG and TXA2
ticlopidine
thromboembolic disease
streptokinase
thromboembolic disease
alteplase
thromboembolic disease
anistreplase
thromboembolic disease
donepezil
aetylcholinesterase inhibitor

prolongs ACh
used in Alzheimer Disease
levodopa
dopamine agonist

used in Parkinson Disease
selegiline
selective inhibitor of monoamine oxidase-B (MAO-B metabolizes dopamine)

used in Parkinson Disease
benztropine
muscarinic antagonist/parasympatholytic
decreases ACh overactivity

used in Parkinson Disease
chlorpromazine
anti-psychotic
typical neuroleptic
α receptor blockade: decreases serotonin, blocks D2?? I think
haloperidol
anti-psychotic
typical neurolptic
α receptor blockade: decreases serotonin, blocks D2
clozapine
anti-psychotic
atypical neuroleptic
α receptor blockade: decreases serotonin, blocks D4 and D2
imipramine
non-selective, tricyclic antidepressant

-antimuscarinic
-antihistaminic
-anti-α
buproprion
non-selective, tricyclic antidepressant

-anti-α
fluoxetine
anti-depressant
selective serotonin reuptake inhibitor
phenelzine
anti-depressant
monoamine oxidase inhibitor
lithium
used in Bipolar Disorder to stabilize mood
diazepam
anxiolytic, anti-epileptic
enhances GABA neurotransmission (increases frequency of opening of GABA mediated Cl- channel)
- requires GABA for effect
pentobarbitol
anxiolytic, anti-epileptic
enhances GABA neurotransmission (increases duration of opening of GABA mediated Cl- channel)
- at high doses will work even without the presence of GABA
phenytoin
anti-epileptic
Na+ channel blocker
carbamazepine
anti-epileptic
Na+ channel blocker
valproic acid
anti-epileptic
inhibits GABA transaminases
morphine
opioid
codeine
opioid
dextromethorphan
opioid
oxycodone
opioid
fentanyl
opioid
meperidine
opioid
naloxone
opioid
loperamide
opioid
diphenoxylate
opioid
prednisone
short-acting steroidal anti-inflammatory
triamcinolone
intermediate-acting steroidal anti-inflammatory
dexamethosone
long-acting steroidal anti-inflammatory
celecoxib
COX-2 selective NSAID
acetaminophen
anti-pyretic, analgesic

unknown mechanism of ↓PG in CNS
antihistamines
allergies
salmeterol
long-acting β2 agonist

used in asthma/COPD
ipratropium
muscarinic antagonist, inhibits vagal induced bronchoconstriction

used in chronic tx of asthma
aminophylline
methylxanthine (tea?)
bronchodilator
increases cAMP causing bronchodilation

used in asthma
cromolyn
unclear mechanism - prevent release of granular contents
used in antigen and exercise-induced asthma
echinacea
saw palmetto
St. John's Wort
ginkgo
botanicals
melatonin
glucosamine
coenzyme Q10
nutraceutical
meclizine
diphenhydramine
H1 antagnoist
anti-emetic
prochlorperazine
D2 antagonist
anti-emetic
metaclopramide
D2 antagonist
anti-emetic/prokinetic
hyoscine
anticholinergic
anti-emetic
aprepitant
NK-1 antagonist
anti-emetic
ondansetron
granisetron
5HT3 antagonist
anti-emetic
domperidone
D2 antagonist
prokinetic
erythromycin
macrolide antibiotic used as a pro kinetic (motilin agonist)
pancrelipase
sulfasalazine
ursodiol
misc GI drugs
aluminum hydroxide
magnesium hydroxide
calcium carbonate
sodium carbonate
acid-peptic

antacids
cimetidine
famotidine
ranitidine
nizatidine
acid-peptic
H2 blockers
misoprostol
acid-peptic
prostaglandin analogues
omeprazole
lansoprazole
acid-peptic

proton pump inhibitors
sucrasulfate
acid-peptic
cytoprotectant
castor oil
senna
aloe
-