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11 Cards in this Set
- Front
- Back
What infection does parvovirus B19 cause? |
Parvovirus b19 is a single stranded DNA virus and the only known host of this virus is human beings. It causes the infection erythema infectiosum or fifth disease. |
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What are the symptoms of a parvovirus B19 infection? |
Classically parvovirus B19 causes the "slapped cheek" rash. Otherwise patients have flu-like symptoms, low grade fever, malaise, arthralgia, and symmetric polyarthralgia especially in the hands. |
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How is parvovirus B19 transmitted? |
Parvovirus B19 is found in respiratory secretions and is thought to be transmitted via these secretions via hand-to-mouth contact as well as infected blood products or transplacentally. |
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What percentage of pregnant women show parvovirus b19 immunity? |
50% |
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What percentage of pregnant women show seroconversion of IgG to parvovirus b19? |
1% |
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How do you diagnose a parvovirus b19 infection in pregnant women? |
Checking for seroconversion. |
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For parvovirus b19 what is the incubation period? What is the time frame for appearance of IgM antibodies? And what is the time frame for appearance of IgG antibodies? |
The incubation period for parvo virus infection is about 1 week. IgM antibodies appear 2 weeks after infection. IgG antibodies appear 3 weeks after infection. |
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What is the vertical transmission rate of parvovirus b19? |
Maternal to fetal transmission is estimated to occur in 17 to 33% of maternal infections in pregnancy. |
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What are the risks to the fetus with vertical transmission of parvovirus b19? |
Typically, the fetus is not affected by maternal parvovirus infection. However they can have a higher risk of fetal death during early pregnancy about 8 to 17% when diagnose from 9 to 20 weeks. It can also cause non immunologic hydrops in the fetus. |
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How is non immunologic hydrops fetalis caused by parvovirus b19 treated? |
Intravascular transfusion of the fetus may have a beneficial effect on parvovirus associated non-immune hydrops fetalis and is most often curative. |
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How is parvovirus b19 infection of the fetus diagnosed? |
Amniocentesis a followed by PCR testing for parvovirus b19. Remember parvovirus is a single stranded DNA virus. |