Obgyn 53: Endometrial Cancer

Front 1

6 RFs for endometrial ca

Back 1

obesity
chronic anovulation
nulliparity
early menarche
late menopause
family ca hx

Front 2

2 (non-histological) kinds of endometrial ca
___ kind has better prognosis
___ kind is more common

Back 2

E dependent (type I)
E independent (type II)
type I
type I

Front 3

4 histological kinds of endometrial ca
most common is ___

Back 3

endometroid
mucinous
clear cell
papillary serous
endometroid

Front 4

___ is the most important prognostic factor for endometrial ca

Back 4

histologic grade

Front 5

2 cancers which constitute familial hx RFs

Back 5

endometrial
HNPCC

Front 6

HNPCC association with endometrial ca is aka ___
this includes ___ (4)

Back 6

Lynch 2 syndrome
CRC
endometrial ca
ovarian ca
breast ca

Front 7

main sx of endometrial ca
this occurs early/late

Back 7

postmenopausal bleeding
early

Front 8

late menopause as RF is specifically ___

Back 8

after 52 yo

Front 9

12 months of OCP use does ___ to endometrial ca risk

Back 9

reduces by 50% for 10 years

Front 10

2 kinds of histopath paramaters used to evaluate endometrial hyperplasia

Back 10

cells
glands

Front 11

cells are graded based on ___
glands are graded based on ___

Back 11

atypia present/absent
shape simple/complex

Front 12

___ is the defining histopath characteristic of premalignant biopsies

Back 12

cellular atypia

Front 13

4 parts of initial workup for postmenopausal bleeding

Back 13

biopsy
TVUS
bloodwork
pap smear

Front 14

bloodwork for postmenopausal bleeding includes ___ (5)

Back 14

CBC
TSH
PRL
FSH
CA-125

Front 15

in Pap smear for postmenopausal bleeding you should look for ___

Back 15

endometrial cells

Front 16

3 options for endometrial biopsy

Back 16

pipelle
D&C
hysteroscopy

Front 17

D&C advantage
D&C disadvantage

Back 17

definitive dx
requires anesthesia

Front 18

high CA-125 indicates ___

Back 18

extrauterine spread

Front 19

on US, endometrial stripe of postmenopausal woman should be ___
unless ___, in which case it should be ___.

Back 19

<5 mm
she's on HRT
<8 mm

Front 20

stage 0 endometrial ca is ___

Back 20

atypical hyperplasia

Front 21

stage 1 endometrial ca is present in ___

Back 21

uterine corpus only

Front 22

stage 2 endometrial ca is present in ___

Back 22

uterus
cervix

Front 23

stage 3 endometrial ca is present in ___

Back 23

pelvis

Front 24

stage 4 endometrial ca is present in ___

Back 24

outside of pelvis

Front 25

main form of spread for endometrial ca is ___

Back 25

direct invasion

Front 26

tx for endometrial hyperplasia without atypia (2)

Back 26

depot medroxyprogesterone acetate (DMPA)
repeat biopsy in 3 months

Front 27

DMPA is aka ___
it is a ___ analogue

Back 27

depo-provera
progesterone

Front 28

tx for atypical endometrial hyperplasia

Back 28

total hysterectomy

Front 29

T/F: cx is removed in total hysterectomy

Back 29

true

Front 30

___ is an option for patients with stage 0 disease who want to preserve fertility

Back 30

conservative (medical) tx

Front 31

before starting conservative tx, you must do ___ in order to ___

Back 31

D&C
rule out cancer

Front 32

conservative tx for stage 0 disease (2)

Back 32

megestrol
norethindrone

Front 33

tx for stage 1 endometrial ca (3)

Back 33

TAH
BSO
pelvic washings

Front 34

tx for stage 2+3 endometrial ca (3)

Back 34

TAH
BSO
pelvic washings
LN dissection

Front 35

tx for stage 4 endometrial ca

Back 35

palliative

Front 36

2 groups of LNs dissected for endometrial ca

Back 36

pelvic
para-aortic

Front 37

___% of endometrial ca is dxed at stage 1

Back 37

73