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37 Cards in this Set
- Front
- Back
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if an osteochondroma becomes malignant what component develops malignancy
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cartilagenous component
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what
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paget's dz of bone, usu localized to one or few bones; thickened irregular bone
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what
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paget's dz of bone - thickened, irregular bone, can see increase in osteoclastic and later osteoblastic activity. can see increased blood alk phosphatase activity from the increase osteoblastic activity
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is Multiple myeloma lytic, blastic or both
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lytic
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name some genetic associations with osteosarcoma
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Paget's disease, fibrous dysplasia, enchondromatosis, and hereditary multiple exostoses
Li–Fraumeni syndrome |
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where in the bone are osteosarcomas found
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metaphysis
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name three epiphyseal bone lesions
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GCT (if growth plate is not closed), clear cell chondrosarcoma and chondroblastoma
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where is fibrous dyplasia found
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diaphyseal
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where are adamantinomas found in bone
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diaphyseal
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where are osteoid osteomas found in bone
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diaphyseal
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where are chondromyxoid fibromas found in bone
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diaphyseal
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besides round cell tumors, what else are usu found in the diaphyseal region of bone
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- adamantinoma
- osteoid osteoma - chondromyxoid fibroma - fibrous dysplasia - fibrosarcoma |
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what
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fibrous dysplasia - chinese letters (thin irregular), fibrotic marrow
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name two syndromic situations in which one can encounter fibrous dyplasia of bone
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McCune-Albright - severe polyostotic fibrous dysplasia, endocrine abnormalities, skin pigmentation
NFII - MISME syndrome (multiple inherited schwannomas (acoustic neuroma), meningiomas and ependymomas (czome 22, merlin gene) |
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two most common locations for a chordoma
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clivus and sacrum
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what
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chordoma, note midline
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genetic association for chordoma
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tuberous sclerosis
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what
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chordoma -
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what
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chordoma
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chemical associations with angiosarcoma
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(PVC) polymerization plants, arsenic-containing insecticides and Thorotrast.
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what
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angiosarcoma
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interesting gross appearance of fibrous dysplasia
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replacement of marrow by fibrosis
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what
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metaphyseal fibrous defect, usually metaphyseal, adolescence (not too far from growth plate and thought to be error in that), if big some call nonossifying fibroma
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most common sites for chondrosarcoma
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pelvis and shoulder, metaphysis/diaphysis of long bones
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what
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chondrosarcoma, often lobulated
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which is a better prognosis conventional osteosarcomas or periosteal osteosarcomas
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periosteal osteosarcomas (usu intermediate grade) vs. high grade of osteosarcomas
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what is a paraosteal osteosarcoma
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low grade, surface fibroblastic sarcoma that produces bone/osteoid, arises from the outer layer of the periosteum and therefore does not elevate the periosteum
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what
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telangiectatic osteosarcoma
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what
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osteogenesis imperfecta - blue sclera
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mutations in osteogenesis imperfecta
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mutations in COL1A1, COL1A2 - AD
type I - good quality collagen, abnl quantity type II - die within year type III - progressively deforming remaining types have subtleties but generally can live with but definitely clinical problems |
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what
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chondromyxoid fibroma- hypocellular lobules with myxod chondroid appearance with band of highly cellular tissue with fibroblast like spindle cells and osteoclasts
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ihc for chondromyxoid fibroma
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S100
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what
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classic appearance of myositis ossificans; often (but absolutely not always) involves muscle, not inflammatory; zonal phenomenon (central cellular area, intermed zone of osteoid formation and peripheral of highly organized bone
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what
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desmoplastic fibroma, rare: medullary; soap bubble
interlacing bundles of dense collagen and low cellularity on histo |
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what
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desmoplastic fibroma
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what
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osteopetrosis
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mutation in achondroplasia
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constitutively active FGFR3, autosomal dominant or sporadic
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