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13 Cards in this Set
- Front
- Back
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Types Of Nucleic Acid Synthesis Inhibitor |
2 types: 1. Direct- (1a)Dna synthesis inhibitor Quinolones, metronidazole. (1b)Rna synthesis inhibitor- Rifampicine. 2. Indirect- Antifolate- Sulfonamide |
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Sulfonamide |
1. derived from prontosil 2. structurally similar to PABA(Para Amino Benzoic Acid) 3. Benzene ring+Amide+ Sulfar 4. Benzene + amide is responsible for antimicrobial activity. 5. Bacteriostatic 6. Lipid soluble 7. Water soluble in salt preparation 8. More stable in alkaline pH |
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Mechanism Of action of antifolate drugs |
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Pharmacokinetics of sulfonamide |
1.Absorption: Small Intestine. 2.Metabolism: Acetylation formation of Acetyl Sulfonamide Crystal 3.Excretion: Acetyl Sulfonamide Crystal is water soluble so excreted through urine. |
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Indication of sulfamethoxazole |
Any Systemic Infection |
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Indication of Sulfasalazine |
Inflammatory Bowel Disease Ulcerative Colitis |
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Indication of Sulfacetamine |
Bacterial Conjuctivitis |
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Indication of Silver Sulfadiazine |
Burn patient Bed Sore Leg Ulcer |
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Classify Sulfonamide According to duration of action |
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Classify Sulfonamide according to route of administration: |
1.Oral: 1a. Absorbable: Sulfamethoxazole, 1b. Non absorbable: Sufasalazine 2.Topical: Sulfacetamine, Silver sulfadiazine |
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What are the Adverse Effects Of Sulfonamide |
1. Renal toxicity- a. Crystalluria b. Hematuria c. Proteinuria d. Anuria e. Renal failure 2. Stevens-Johnson Syndrome 3. Lyell's syndrome- epidermal necrosis 4. Hematological- a. Bone marrow depression. b. Hemolytic anaemia. c. Aplastic anaemia. d. Thrombocytopenia. 5. Others- a. Photosensitivity b. Rash c. GIT upset d. Hepatitis |
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Crystalluria Rx |
1. Intake plenty of water to dissolve the crystals 2. Alkalization of urine. |
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Write About Stevens-Johnson syndrome |
It is a life threatening condition. Erosion of mucus membrane of- Mouth, Eye, GIT, Respiratory tract, Bladder, Rectum, Vagina. Symptoms: fever, butterfly rash Treatment: Stop the drug immediately. |
