Nsaids

Front 1

cox 1

Back 1

is general enzyme

Front 2

cox 2

Back 2

inducible

Front 3

2 types of nsaid

Back 3

non selective and selcetive

Front 4

non selective

Back 4

aspirin

Front 5

2 paths for arach

Back 5

lipoxygenase and cox

Front 6

other name for cox

Back 6

pg sythetase

Front 7

nsaid side effect

Back 7

blockade of platelet aggregation (inhibits thromboxane synth), gi ulceration, uterine dysmotility, hypersensitivity, can use misoprostol which is a pge analogue to prevent gi tox

Front 8

non selective v 2

Back 8

gast ulcer: NS
inhib of platelet: NS
inhib of labor induction: NS and 2

Front 9

aspirin:
what does this mean?

Back 9

irreversible acetylation of cyclooxygenase
Effect on platelet will last life of platelet 8-10 days

Front 10

aspirin adverse

Back 10

tinnitus, deafness
renal function
gi
hepatotox

Front 11

salicylate intox

Back 11

acid base balance:
respiratory alk follow by metab acidosis

Front 12

other uses

Back 12

juvenile rheum

decrease risk of mi by 40% by taking 81 mg aspirin per day
dec inci of colon cancer

Front 13

diflunisal

Back 13

difluorophenyl derivative of sal acid
more effectie and longer dur
less

Front 14

mesalamine

Back 14

salicylate used for local effect
in inflam bowel disease

Front 15

acetaminophen

Back 15

analges, antipyr, but weak antiinflam

Front 16

side effects

Back 16

lacks side effects of aspirin,

Front 17

acetamin metab

Back 17

glucuronide
but problem is that it can form toxic intermediate by being effected by p450 mixed function oxidases to form n acetyl b benzoquinone imine....this intermediate can continue and produce cell death

Front 18

acetylcysteine

Back 18

antidote for tylenol poisoning

Front 19

Indomethacin

Back 19

probenecid inhibits renal excretion of indo

Front 20

adverse
other use

Back 20

severe frontal headache
can close patent ductus

Front 21

sulindac

Back 21

pro drug,
less ulcerogenic

Front 22

tolmetin

Back 22

adverse: gi n/v,
cns, less common than indomethacin

Front 23

diclofenac

Back 23

reduce synth of both pg and leukotrienes....so both cox and lox inhib

Front 24

adverse

Back 24

gi, hepatotox

Front 25

ketorolac

Back 25

first injectable nsaid

Front 26

mech

Back 26

pg synth inhib

Front 27

use:

Back 27

short term management of moderately severe acute pain

Front 28

Ibuprofen

Back 28

mild inflam and analgesic

otc, however

Front 29

naproxen

Back 29

20x more potent than aspirin, long half life 14 hour, approved for acute gout, ank spon, this is aleve

Front 30

ketoprofen

Back 30

lox and cox

Front 31

oxaprozin

Back 31

newer propionic acid
around 40-60 hour halflife

Front 32

piroxicam

Back 32

long half life around 50 hours

Front 33

which nsaid is irreversible

Back 33

aspirin

Front 34

meloxicam

Back 34

inhib cox 2 over cox 1

Front 35

nabumetone

Back 35

cox 2 prodrug

Front 36

celecoxib

Back 36

first cox2 selective nsaid, approved for arthritis

Front 37

celecoxib advrse

Back 37

cardiovascular

Front 38

vioxx

Back 38

withdrawn in september 2004

Front 39

cox 2 adverse

Back 39

black box warning

Front 40

disease modifiying anti rheum drug

Back 40

abatacept, rituximab, etc

Front 41

abatacept

Back 41

inhib t cell activation
single use for IV injection

Front 42

rituximab

Back 42

monoclonal ab against cd20 on b lymphocytes

Front 43

etanercept

Back 43

binds to tnf and blocks interaction

Front 44

adalimumab

Back 44

binds tnf alpha specificall and blocks p55 and p75
10 to 20 day half life

Front 45

infliximab

Back 45

inhib interaction of tnf a with receptor, long half life