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27 Cards in this Set
- Front
- Back
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What is the first sign of nicotene overdose?
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nightmares, lethal in children, don't confuse with withdrawal sx
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How do neuroleptic drugs work?
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competative inhibitors of a variety of receptors, most block dopamine some add anti-histamine
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What are the two biggest targets of neuroleptic drugs?
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dopamine and histamine
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What happens if we give neuroleptic drugs to people without psychoses?
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tardive dykenesia, depression, it is a downer
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What are side effects fo phenothiazines?
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extrapyramidal rxn, tardive dyskenesia
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atypical antipsychotics?
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probably acts different then the older ones, probably does not work very well, used adjunctively,
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What is ariprprazole?
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atypical antipsychotic; works on collaterol receptors (non-direct); bipolar I, major depression
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Parkinson's tx?
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carbodopa and levodopa combo; usually ends up with multiple meds when this stops working; ergots are the old ones (bromocriptine)
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Secondary tx for parkinsons
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pramipexole, ropinirole- non-ergots
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SAMe ?
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methyl donor and kicks up catecholamine production in the periphery and brain gets some
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What 3 drugs block dopamine reuptake?
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amphetamine, cocaine, and buproprion
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When should you use MAO inhibitors?
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late stage parkinson's, keep dopamine in the brain also lots of other substances
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SE of MAO?
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too much catecholamines and serotonin when used with other drugs; tons of interactions
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What drugs lower the seizure threshold??
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anything that kicks up catecholamine production; Buproprion
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What type of depression is occuring with insomnia?
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serotonin deficient and usually use alcohol to sleep
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what drug inhibits serotonin and beats up serotonin receptors?
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LSD
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What are the sx of serotonin syndrome?
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fever, hyperreflexia, BP changes, coma, death
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St. Johns wort induces what liver system?
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Phase I P450 3A4
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What other action does acetylcholine have other than muskuloskeletal?
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Memory
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What nutrient donate to acetylcholine?
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phosphatidyl choline
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Donepezil, tacrine hydrochloride, galantamine, rivastigme
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acetycholine sparing
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What is memantine hydrochloride job?
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NMDA receptor antagonist, which blocks excitatory nt glutamate
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CNS acting sleep drugs?
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amyltriptaline, trazadone, anti-histamine
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What side effect does progesterone have on the CNS?
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activates the GABA receptor
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Why should you not drink alcohol with barbituates
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both work on the GABA system, cause respiratory depression
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How do seizure drugs work?
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they effect ion channels in the brain, calm the brain down
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Glycine is CI in what group of patients?
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Bipolar
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