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44 Cards in this Set
- Front
- Back
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What are the precursor lymphoid neoplasms? |
1. ALL 2. LBL |
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What are the mature lymphoid neoplasms? |
1. Non-Hodgkin 2. Hodgkin |
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What is a lymphoblastic lymphoma? |
1. Mass lesion with no/minimal blood or bone marrow involvement 2. Mostly T-cell |
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What is a lymphoblastic leukemia? |
1. Significant involvement of blood/bone marrow involvement 2. Most are B-cell |
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What are the clinical features of B-ALL? |
1. Extramedullary involvement 2. Lymphadenopathy 3. Hepatosplenomegaly 4. Bone pain and arthralgia |
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What is the prognosis in B-ALL/LBL? |
1. Good in children 2. Less favorable in adults 3. CNS disease worse prognosis |
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What are the results of a blood smear in B-AL/LBL? |
1. No dysplastic myeloid cells 2. Leukoerythroblastosis common 3. Hypercellular marrow 4. NO AUER RODS |
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1. B-ALL/LBL 2. No auer rods 3. No dyspoiesis |
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1. ALL: packed marrow |
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What are the cytogenetic abnormalities in B-ALL/LBL? |
1. t(9;22)--Poor prognosis 2. t(12;21) TEL/AML 1-- excellent prognosis 3. t(v;11q23) MLL rearranged-- poor prognosis |
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What is involved in CLL/SLL? |
1. Peripheral blood and bone marrow 2. Lymph nodes 3. Liver 4. Spleen |
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What are the clinical features of CLL/SLL? |
1. Fatigue 2. AHA 3. Infections 4. LAD 5. Hepatosplenomegaly
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1. CLL/SLL LAD |
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1. CLL/SLL peripheral blood 2. "Soccer ball pattern" in chromatin |
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1. CLL/SLL lymph node 2. Darker: lymphocytes
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1. CLL/SLL bone marrow 2. Nodules in marrow |
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What is CLL/SLL transformation? |
1. Becomes more aggressive 2. Develop prolymphocytes (larger) 3. Richter: development of diffuse large B-cell lymphoma--- bad news |
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1. CLL/SLL transformation: Richter |
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1. CLL-prolymphocytic leukemia |
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What are the characteristics of myeloma? |
1. Bone marrow-based 2. Plasma cell neoplasm 3. M-protein in urine 4. Lytic lesions, bone pain |
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What is the effect of malignant plasma cells on normal plasma cells in myeloma? |
1. Suppress proliferation of normal plasma cells |
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1. Lytic lesion in myeloma |
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1. Myeloma |
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1. Perivascular amyloid |
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What are the characteristics of extraneous plasamacytoma? |
1. Outside bone marrow 2. Often in head/neck 3. Responds well to radiotx 4. Good prognosis |
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What are the characteristics of solitary plasmacytoma of bone? |
1. Solitary, localized bone tumor of monoclonal plasma cells 2. M-protein 3. No clinical features of myeloma
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How does solitary plasmacytoma of bone present? |
1. Pain at site 2. Fractures |
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How do you tx solitary plasmacytoma of bone? |
1. Radiotx |
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What are the characteristics of extra nodal marginal zone lymphoma of MALT type? |
1. Arise in tissues involved with chronic inflammatory disorders 2. Associated with H. pylori in stomach 3. Localized |
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1. Extra nodal marginal zone lymphoma of MALT type |
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What is the second MC form of non-Hodgkin lymphoma in the US? |
1. Follicular lymphoma |
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1. Follicular lymphoma |
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What is the prognosis of follicular lymphoma? |
1. Mostly incurable
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What are the characteristics of mantle cell lymphoma? |
1. Lymph node involvement 2. GI tract involvement 3. Incurable |
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What is involved in hairy cell leukemia? |
1. Bone marrow 2. Spleen 3. Peripheral blood, marrow |
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What are the peripheral blood signs of hairy cell leukemia? |
1. Monocytopenia 2. Pancytopenia common |
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What are the marrow signs of hairy cell leukemia? |
1. Fried egg on bx 2. Fibrotic marrow |
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What is the prognosis of hairy cell leukemia? |
1. Excellent |
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1. Hairy T cell leukemia |
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What proportion of non-Hodgkin's lymphoma is made up by DLBCL? |
1. 30-40% |
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What are the characteristics of DLBCL? |
1. Arises de novo 2. Underlying immunodeficiency is a significant risk factor |
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What are the characteristics of Burkitt lymphoma? |
1. EBV 2. Immunodeficiency-associated 3. Extranodal sites/acute leukemia |
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What is the prognosis of Buritt lymphoma? |
1. Highly aggressive but potentially curable
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What is the immunophenotype of BL? |
1. CD19, 20, 10, BCL6 and CD38 positive 2. CD34 and TdT uniformly negative |
