Neuronal Drug Mnemonics

Front 1

What type of G protein is each andrenergic receptor? mnemonic?

Back 1

beta- both Gs - like caffeine
a1- Gq (vasoconstriction needs calcium)
a2-Gi

Front 2

mnemonic for uncompetitive vs noncompetitive?

Back 2

non competitive is "no contest" they take the seat and stay there every time.

u for underhanded. They take the sneaky backway to inhibit

Front 3

ANDRENERGIC ANTAGONISTS

Back 3

SLOW DOWN!

Front 4

Mnemonic for Reserpine?

Back 4

vesicle is like a reservation for catecholamines.
Reserpine USURPS the ability for catecholamines to gain refuge there.

Front 5

Mnemonic for guanethidine and bretylium?

Back 5

GUAN and BRETT are two best friends who took up jobs as security guards who block vesicles from binding.

Front 6

What does alpha methyl DOPA do?

Back 6

this fake DOPA is DOPE at being a master of disguise. It tricks everyone and becomes an ineffective alpha methyl NE in the vesicle.

Front 7

metyrosine?

Back 7

metyrosine will MET his death very early on

binds irreversibly with tyrosine hydroxylase

Front 8

NOW WE TALK ABOUT ANDRENERGIC AGONISTS

Back 8

YOU SPIN ME RIGHT ROUNF, BABY!

Front 9

Mnemonic for phenylephrine?

Back 9

it sounds very close to pseudoephedrine (sudafed) because it is the new replacement for it in decongestants.

Sorry, Walter White..

Front 10

What does epi stimulate? Mnemonic?

Back 10

everything except a2.

Think about the effects f an epipen. Racing heart (B1), vasoconstrcition (a1), and bronchodilation (b2)

Front 11

Mnemonic for norepinephrine?

Back 11

it activates a1 in vivo

Front 12

Mnemonic for clonidine?

Back 12

it was those little yellow pills that mellowed people out. Artem gave some to Ayla for her birthday.

A2 agonist. (inhibits the body's natural NE production)

Front 13

Mnemonic for isoprotenerol.

Back 13

this brother spent all his time ISO-lated doing acid (PROT) that his brother went above and beyond (META) and took his job as a respiratory therapist even though he also did acid.

Isoproterenol- B1 and B2
Metaproterenol- B2

Front 14

Mnemonic for albuterol.

Back 14

However, ALBert is still the best respiratory therapist. (B2)

Front 15

Mnemonic for dopamine

Back 15

stimulates B1 and D
also A1 at high doses

Dopamine is a very good thing. Too much of a good thing can have bad consequences though.

we wanted to give dopamine to the hemorrhagic pt who was taking aspirin so that we could raise her blood pressure (b1 and a1) while sparing her already constricted renal arteries (D).

Front 16

Mnemonic for dobutamine.

Back 16

dobby will help pump that heart!
B1 for cardiac stimulation.

Front 17

Name the B2 stimulants? Mnemonic?

Back 17

It is SMART to take a B2 stimulant for an asthma attack.

Salbutamol
Metaproternol
Albuterol
Ritodrine
Tertbutaline

Front 18

What is the story behind isoproternol's relationship with albuterol and tertbutaline?

Back 18

James said that they added a tertbutyl group to make albuterol from isoprotenerol to make it more specific for B2 only.

That's not true to their structure, but it helps me remember they are both catecholamines and work for asthma.

Front 19

Mnemonic for what isoprotenerol used to do vs what it does now?

Back 19

used to treat asthma, but did too much cardiostimulation. Now it has turned it's weakness into it's strength and is used to stimulate the heart in emergency situations.

Front 20

Mnemonic for metaproterenol?

Back 20

it's like isoproterenol, but it goes META and one step furhter to be better at treating asthma by doing only B2.

Front 21

Mnemonic for metaproterenol, isoproterenol, acid, and asthma?

Back 21

Isoproterenol was an ISOLATED hippie doing acid (PROT). He lost his job as a resp therapist cause he couldn't handle both.

His brother went META and was able to do both and replaced him.

Front 22

Which B2 agonists is used to prevent premature uterine contractions? Mnemonic?

Back 22

tertbutaline and ritodrine

rhyhorne is going to have triplets (tert)! Quick, we have to give tertbutaline to keep them back!

Front 23

Which drugs are recommended for short vs long term asthma?

Back 23

short- albuterol and metaproterenol
long- salbuterol (better call Saul sticks around for a long time. He even got his own show now)

Front 24

Which drugs are recommended for short vs long term asthma?

Back 24

short- albuterol and metaproterenol
long- salbuterol (better call Saul sticks around for a long time. He even got his own show now)

Front 25

NOW WE TALK ABOUT INDIRECT SYMPATHOMIMETIC DRUGS!

Back 25

aksjfdk

Front 26

Mnemonic for drugs that block reuptake.

Back 26

When he couldn't REUP on cocaine, the drug dealer started substituting tricyclic antidepressants because they have the same mechanism, but less strong.

Front 27

What NT's do they block the reuptake of? Mnemonic?

Back 27

all the monoamines (they give you the full experience).

Front 28

What is the more selective version of tricycclic antidepressants?

Back 28

SELECTIVE serotonin reuptake inhibitor (SSRI)

Front 29

What is the action of amphetamines? Mnemonic?

Back 29

they promote the fusing of the vesicle and the membrane to release NE and Dopamine. This is why you can suffer depletion symptoms the day afterwards.

Front 30

What 2 drugs works similar to amphetamines? Mnemonic?

Back 30

tyramine and ephedrine

Tyra banks acts like she is on amphetamines sometimes and she is also thin like she is on ephedrine.

Front 31

How do you remember that it is mainly a1 and b2?

Back 31

a1- b1 is very unique to the heart in drugs and a1 is more body-wide

b2- up till now, I didn't think a2 even did anything

Front 32

What did bella donna do to simulate attraction/orgasm? What is this drug called?

Back 32

drip atropine into her eye to dilate it.

Front 33

CHOLINERGIC SYSTEM

Back 33

CHOLLY MOLLEY!

Front 34

What is the role of hemicholinium? Mnemonic?

Back 34

it blocks the uptake of choline in the nerve ending, making it impossible to get that half (HEMI) of ACh

Front 35

What is the role of vesimicol? Mnemonic?

Back 35

same as reserpine for sympathetic vesicles. blocks transfer of ACh into the vesicle.

VESI- vesicle
COL- cholinergic

Front 36

What receptors do each of these drug endings serve?
1. -olol
2. -terol
3. -zosin

Back 36

1. -olol - beta blocker
2. -terol - B2 agonist
3. -zosin - A1 blocker

Front 37

Mnemonic for botulism toxin?

Back 37

it prevents fusion of the synaptic vesicles for cholinergic neurons at the NMJ and parlysis your muscles.

Think about people who get botox

Front 38

Mnemonic for black widow venom aka latrotoxin?

Back 38

widows look much older so they do the opposite mechanism of botulism.

however, their effects are all over the PS system, not just the NMJ

their analogous effector in S is amphetamines

Front 39

Why are these channels called "nicotinic"?

Back 39

because nicotine can also bind in place of ACh and produce the same results

Front 40

`What sx does Liane get from her lithium? How do you explain them?

Back 40

extreme hunger and thirst
thirst because ADH action on the collecting tubule is blocked, causing nephrogenic diabetes insipidus

Front 41

What the the analogous EPP created on post synaptic membranes?

Back 41

Excitatory Post Synaptic Potential (ESPS)

Front 42

What is the resting membrane and threshold potential on the post synaptic membrane?

Back 42

the same as the NMJ

Front 43

What is the neuronal nicotinic receptor called?

Back 43

Nn

Front 44

What are the similarities and differences between Nm and Nn?

Back 44

they both react to ACh the same way, but different drugs can selectively affect each receptor

Front 45

What types of nicotinic receptors are in the brain? (GPe)

Back 45

Nn

Front 46

Besides ACh and Nicotine, what else in our body can bind the nicotinic channels?

Back 46

Succinylcholine

Front 47

What is different about the effect of succinylcholine? What is the downside of this?

Back 47

it stays there. it results in desensitization.

Front 48

Why does ACh not cause desensitization?

Back 48

it is immediately broken down by ACh-esterase

Front 49

What is it broken down into and where do these products go?

Back 49

Acetate
Choline - reused in the nerve terminal

Front 50

What is the long term effect of succinylcholine?

Back 50

paralysis (can only twitch the muscle on command)

Front 51

Mnemonic for ACh vs succinylcholine on nicotinic receptor. Kisses from gf.

Back 51

ACh- Gf kisses you once a minute and each time is still exciting
Succinylcholine- Gf keeps her lips attached to you and after a while you are desensitized and no longer excited. (too sexy)

Front 52

What would prevent any girls from kissing you? (Nm channel)

Back 52

to put a cup over your lips.

Tuberculin

Front 53

Which muscarinic receptors are excitatory vs inhibitory? Mnemonic?

Back 53

If you make a W with you hand with the middle finger up, each represents a M receptor. All the ones pointing up are excitatory.

Excitatory- 1, 3, 5
Inhibitory- 2,4

Front 54

What G protein do all the excitatory muscarinic receptors use?

Back 54

Gq

Front 55

What is the toxin used for clostridium tetani?

Back 55

tetanospasmin (causes tetanus and muscle spasticty by inhibiting GABA and Glycine release in the spinal cord)

Front 56

What sleeping disorder can GABA treat?

Back 56

insomnia

Front 57

Mechanism mnemonic for barbituates and benzodiazepines?

Back 57

barbiDURATes- prolong the duration of GABA channel opening

FRENzodiazepines- increase the frequency of GABA channel openings

Front 58

What well known drug treats insomnia by increasing GABA?

Back 58

Ambien

Front 59

What is the receptor for GABA?

Back 59

It is a ligand gated chloride channel

Front 60

What happens when you stimulate it?

Back 60

It lets chloride in nd lowers the membrane potential so that the post synaptic neuron is harder to stimulate.

It produces an IPSP

Front 61

What happens to glutamate stimulation when you also have GABA inhibition?

Back 61

it does not become enough to hit threshold

Front 62

What root do all choline esters have in common?

Back 62

-CHOL

Front 63

Mnemonic for action of Bethanechol?

Back 63

Beth activates Bowels and Bladder

Front 64

Mnemonic for carbachol?

Back 64

if you have glaucoma fluid in your eye, dab a piece of bread (CARB) to clear it up

Front 65

Mnemonic for methacholine?

Back 65

breath-a-choline

you are inhaling choline (esterase) which is a bronchoconstrictor to test for asthma. (why else would you wanna inhale choline?

Front 66

What is the rule for direct cholinergics naming?

Back 66

they all contain CHOL (because they mimic ACh) except for pilocarpine

Front 67

Mnemonic for side effects of Pilocarpine?

Back 67

You dry, sweat, and drool onto your PILOw

Front 68

Mnemonic for both pilocarpine and carbachol used for glaucoma?

Back 68

both have CARB/P's for the bread

Front 69

mnemonic for physostigmine and donepezil.

Back 69

sounds like pfizer.

pfizer is the don of pharmaceuticals. they can get inside your head (quite literally) and everywhere else.

Front 70

What suffixes do the irreversible antiACE's have? (not in 1st aid)

Back 70

-phate and -thion

Front 71

mnemonic for pralidoxime?

Back 71

farmers working in the PRArie mayy need pralidoxime as an antidote

Front 72

Mnemonic for which drugs to use first for glaucoma.

Back 72

first, try to cry into your PILOw (pilocarpine). If that doesn't work, you can try dapping another piece of bread into your eyes (Carbachol) or calling Pfizer (physostigmine) or NEO(stigmine) for backup.

Front 73

What is the main use of physostigmine though? Mnemonnic?

Back 73

to reverse the effect of atropine

Physostigmine "phyxes" atropine overdose

Front 74

Mnemonic for NEOstigmine? (2)

Back 74

NO CNS penetration

Also NEO from the matrix can do a lot of stunt, which require very good working muscles. (great at stimulating NMJ)

Front 75

Mnemonic for eaton-lambert vs myasthenia gravis?

Back 75

there are two people and a cooked lamb on the table.
MG- starts out eating it well and then can no longer
EL- starts out slow, but is eventually able to successfully EAT the LAMB

Front 76

What disease is eaton lambert associated highly with? Mnemonic?

Back 76

Small cell (oat cell) carcinoma (lung cancer)

You have the lamb with a side of oats

Front 77

Mnemonic for short and long term drugs to treat myasthenia gravis?

Back 77

NEO(stigmine) uses a lot of muscle to climb the PYRImids (pyridostigmine).

P for prolonged
NEO in short term

Front 78

Mnemonic for use of Edrophonium?

Back 78

This is a PHONEY drug

You use it to dx myasthenia gravis because it lasts for such a short time (doesn't bind tightly to ACE because of OH instead of carbamate group)

Front 79

Mnemonic for botulism toxin?

Back 79

brett got botox

(prevents vesicle fusing just like bretylium and guanethidine)

Front 80

Mnemonic for which drug is used for alzheimer's.

Back 80

The old DON has Alzheimer's

Front 81

What is the mnemonic for cholinergic crisis?

Back 81

Sine ACh help learning, when you have a lot of it, you are....
DUMBBLESS!
Diarrhea
Urinary incontinence
Miosis
Bradycardic
Bronchoconstriction
Lacrimation
Excitation of skeletal muscle and CNS
Sweating
Salivating

Front 82

What is the downside to wearing atropine to a date? Mnemonic with duration?

Back 82

you get relaxation of ciliaris and can't see your date. It's a big sacrifice for beauty because atropine in the eyes creates cycloplegia for 3-4 days.

Front 83

Mnemonic for each of these dilating pupil drugs?
1. Homoatropine
2. Tropicamide
3. Cyclopentalate

Back 83

1. Homoatropine - works just like atropos belladonna
2. Tropicamide - better bring sunglasses if you are going to the tropics
3. Cyclopentalate- cyclopentalate causes CYCLOplegia

Front 84

Mnemonic for oxybutynin?

Back 84

If I need to pee like an ox, I should PUT IN oxybutynin.

antimuscarinic for stress incontinence (bladder spasms) and cystitis

Front 85

Mnemonnic for glycopyrrolate

Back 85

I am getting ULCERS just thinking about my surgery. My stomach (digests glucose) is on fire (pyrrole).

treats ulcers and used for preop

Front 86

Mnemonic for prlidoxime

Back 86

pulls the alkyl group off ACE before aging

I will pry the lid off this ACE

Front 87

Mnemonic for medical use of scopolamine

Back 87

motion sickness

at least those drugged up women won't get car sick while they are being kidnapped

Front 88

Mnemonic for use of Benztropine and trihexylphenidyl?

Back 88

tropine- atropine (anticholinergic)
used for Parkinson's

"A triple hex upon the valet who Parked my Benz! there is a scratch on it"

(previous mnemonic was easy to confuse with alzheimer's)

Front 89

Mnemonic for ipatropium and tiotropium?

Back 89

I PRAy (ipatropium) I can breathe soon. TIO prays for me later.

(couldn't make the last one work well)

Front 90

mnemonic for succinylcholine

Back 90

Succinylcholine will SUCK face all day long

ACh- Gf kisses you once a minute and each time is still exciting
Succinylcholine- Gf keeps her lips attached to you and after a while you are desensitized and no longer excited. (too sexy)

Front 91

Mnemonic for Labetalol

Back 91

1. ends in -alol so it is a blocker of beta
2. reverse la- to make A1
3. couple these together and it is a combined nonselective beta and A1 blocker

Front 92

What is cardioselectivity?

Back 92

affecting only the heart, usually referring to B1 blockers

Front 93

What are some cardioselective beta blockers? (3)

Mnemonic?

Back 93

THEY ALL END IN -O/ALOL and block B1 selecively.

Acebutalol- Ace is a pretty small card number and also stands for 1. So blocks B1!

Metoprolol- met- is a prefix that indicated something short like methyl

Atenolol- it's effects are atenuated to B1

Front 94

Mnemonic for methylphenidate?

Back 94

Take some Concerta before you go out on your FUN DATE! (it will lessen anxiety)

Front 95

Mnemonic for dangerous side effect for tubocurarin.

Back 95

It mediates histamine release from mast cells, which is really bad for asthmatics

Imagine an asthmatic getting intubated and getting hit with a poison dart.

Front 96

Mnemonic for Timolol.

Back 96

-olol with no shortening mnemonic so nonselective beta blocker

It's TIMe to stop glaucoma!

Block aqueous humor production.

Front 97

Tacarine?

Mnemonic?

Back 97

an ACE inhibitor used for Alzheimer's.

The Don will pop some tic tacs to help remember.

Front 98

Mnemonic for methylphenidate?

Back 98

A dopamine reuptake inhibitor

Take some Concerta before you go out on your FUN DATE! (it will lessen anxiety)

Front 99

What kinds of drugs will inhibit COMT? suffix?

Mnemonic?

Back 99

-capone

Al Capone is waiting on the other side (post synaptic) waiting for COMbaT! (COMT)

Front 100

Mnemonic for TOL-capone and ENTA-capone?

Back 100

You must may a TOLL to ENTA(er) Al Capone's house without him killing you in COMbaT!!

Front 101

Mnemonic for all 4 antimuscarinics to tx Parkinson's.

Back 101

A TRIPLE HEX (trihexylphenidyl) upon the valet that PARKED (parkinson's) my BENZ (benztropine)! Good thing I am BIPEDAL (biperidan) so I can go PRO CYCLING (procyclidine) my bike back home!

Front 102

Mnemonic for Amantadine?

Back 102

Wolverine (Amantadine) first conquered the flu and then dabbled in Parkinson's in many different ways! He is so dreamy that I get a release of Dopamine every time I see him (DA release)

*only works for a couple weeks

Front 103

Mnemonic for ergot Dopamine Agonist for Parkinson's? (2)

Back 103

I'm gonna visit my hippe BRO from PERG in his CRYPT (bromocryptine) for some LSD (ergot). It's gonna be DOPE! (dopamine agonist)

Front 104

Suffix for MAO B inhibitors?

Mnemonic?

Back 104

-giline (sele- and rasa-)

You're going to have to put that bobcat (MAO B) to the GUILITINE (-giline) if you want your DOPE!(dopamine)

Front 105

Mnemonic for L-DOPA and carbidopa?

Back 105

easy, L-dopa is a precursor and carbidopa is the deCARBoxylase that goes along with it.

Carbidopa doesn't cross the BBB so it eliminates all the systemic andrenergic effects.

Front 106

Mnemonic for botox?

Back 106

Botox shouldn't be legal because it affects ALL cholinergic nerves, but people are desperate! (people have died)

Front 107

Mnemonic for tolcapone's side effects and scope?

Back 107

toL- TOLL to go through BBB and L for causing LIVER TOXICITY

Front 108

Mnemonic for non ergot dopamine agonists.

Back 108

Apomorphine, pramipexole, ropinirole, and rotigotine

I didn't really like that hippie bro dealer's stuff. I'm off of LSD to better dope. I'm gonna take some MORPHINE (apomorphine) and go to PROM (pramipexole) to see if I can ROPE (ropinorole) a girl into the ROLE of gf with my ROTWEILER (Rotigotine- Rotty will got you in!).

Front 109

What is the first line drug for partial seizures? Mnemonic?

Back 109

Cabamazepine because you can drive in a car with a partial seizure more than the others.

Front 110

WHat is the first line drug for absent generalized seizures? Mnemonic?

Back 110

ethosuximide.

If you are absent from me, then your ETHOS totally SUX!

Front 111

What is the second line drug for absent seizures?

Back 111

valproic acid

Front 112

What is status epilepticus? Mnemonic?

Back 112

a seizure that lasts more than 3 minutes. It can be several seizures WITHOUT REGAINING CONSCIOUSNESS IN BETWEEN.

You have this status for a long time! It is your whole being!

Front 113

What kind of phentoin should you use if you are giving it IV? Why? Mnemonic?

Back 113

phenytoin irritates the blood vessels so you have to give fosphenytoin, which is not FUSSY with the veins.

Front 114

Go through the steps you should take with someone who is having a status epilepticus seizure?

Back 114

1. secure airway (their muscle of respiration aren't working well)
2. give oxygen
3. give benzodiazepine bolus
4. if that doesn't work, give phenytoin

Front 115

Mnemonic for Valproic acid?

Back 115

VAL is a PRO at GABBing her mouth off to EVERYONE!

Valproid increases the odd to GABA in every whay imaginable.

Front 116

What does every 5-HT agonist anti migraine drug end in?

Back 116

-triptan

You must be TRIPpin if you are coming to me to get rid of your migraines! You must be desperate (already starting) for me to squeeze (vasoconstricting) that out of you!

Front 117

Mnemonic for usage of phenoxybenzamine?

Back 117

It sounds very similar to and the word is very long like pheochromocytoma.

It is used to prevent hypertension during the tumor removal when a lot of catecholamines may be released

Front 118

What do the suffixes -ipramine and -tryptyline point towards? (mnemonic)

Back 118

TCA's

I PRAY MEAN (ipramine) people will never TRIP (tryptiline) me. That would make TRIPLE depressed.

TRIPTYLINE = TRICYCLIC

Front 119

menmonic for what a neuroleptic is.

Back 119

It is going to just cut through all the neurological nonsense involved in psychosis.

Front 120

Suffix for two types of neuroleptics?

Back 120

-operidol and -azine

My imaginary friend, "Oh Perry Doll," I shall write A ZINE for you!

Front 121

What trade name is phenytoin named after?

Why is it such an effective drug?

What epilepsies is it used to treat? (2 first line, 2 second line)

Mnemonic for phenytoin and what types of seizures it treats?

Back 121

Dilantin.

It binds to and nactivates to sodium channels only when their inactivation gates have been showing for a while. Thus, fast open/close sodium channels are spare, but longer opening ones like in seizures of the tonic-clonic (first line) and status epilepticus (prophylaxis) types are affected.

For these serious seizures, we're going to have to DIAL it up!! (dilantin)

Front 122

Mnemonic for tiagabine and vigabatrin actions?

Back 122

Mnemonic for tiagabine and vigabatrin actions?

Front 123

WHat exactly do they do to increase GABA?
Mnemonic?

Back 123

Tiagabine- inhibits GABA reuptake (Tia won't let GABA go! She loves him too much)
Vigabatrin- inhibits GABA breakdown (makes GABA more VIGorous)