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18 Cards in this Set
- Front
- Back
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what is the definition of MS?
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MS is a chronic inflammatory demyelinating disease of the CNS
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what are the sites of lesion?
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cerebrum
brainstem cerebellum optic nerve spinal cord |
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What is the nature of lesions in MS?
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-Perivascular cuffing and parenchymal infiltration with T lymphocytes and macrophages
-primary demyelination -loss of oligodenrocytes -axonal transection -axonal degeneration -gliosis |
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what is the role of EBV in MS?
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EBV is a prerequisite for the development of MS.
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What is the treatment of Mild Relapse of RR-MS?
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nil
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Treatment for SP-MS and PP-MS?
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IV high dose methylprednisone.
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Treatment for RR-MS not responding to IFN and glatiramer?
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Natalizumab
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Treatment for RR-MS intolerant to IFN-B?
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Glatiramer acetate
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Treatment for RR-MS?
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Interferon B
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Treatment for Mod-severe relapse of RR-MS?
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IV high dose methylprednisone
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How does Natalizumab work?
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Monoclonal antibody against alpha4beta1 integrin.
Inhibits entry of circulating lymphocytes and monocytes into CNS. |
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What is the side effect of Natalizumab?
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Progressive multifocal leukoencephalopathy.
Rebound effect with increased autoimmune attack on CNS 3 months after cessation of treatment. Hypersensitivity reaction. |
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How do you treat spasticity?
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Baclofen
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How do you treat neurogenic pain?
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Amitriptyline
Gabapentin |
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how do you treat epilepsy in MS?
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sodium valproate
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How do you treat persistent severe fatigue not due to depression?
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Amantadine
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Name the type of MS?
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1) relapsing-remitting
2) primary progressive 3) secondary progressive |
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what is the investigation of choice for diagnosing MS?
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Brain/spinal MRI
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