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16 Cards in this Set
- Front
- Back
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1.Sodium channel blocker |
Stablize channel in inactive form x repetitive firing of axons |
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Carbamazepine |
First line antiepileptic Na Channel blocker induces hepatic cytochrome P450 |
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Phenytoin |
First line antiepileptic 1.Na Channel blocker, also inhibit Ca influx Strong inducer of hepatic enzymes High protein bound X pregnancy |
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Lamotrigine |
1.Na Channel blocker X induce or inhibit hepatic enzymes at low dose Choice for pregnant women MOA: 1 block volt gated NA channel 2) inhibit glutamate release (excitatory NT) |
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Ethosuxmide |
2.Calcium channel blockers MOA: block channels, inhibit depolarization X pregnancy |
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3.GABA enchaners |
MOA: GABA (inhibitory neurotransmitter) bind to receptor, influx of Cl- , increase -ve, difficult for AP |
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Clobazam Clonazepam |
3a.GABAa agonist |
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Tiagabine |
3b.GABA reuptake inhibitor inhibit GABA-transporter-1 (GAT-1) |
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Vigabatrin |
3c.GABA-transaminase inhibitor inhibit breakdown of GABA |
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Gabapentin Valproate |
3d.Glutamic acid decarboxylase (GAD) modulation increase synthesis of GABA |
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Topiramate |
4.Glutamate blockers MOA 1. inhibit AMPA and kainate subtype glutamate receptor 2. Inhibit sodium conductance (AP) 3. Enhances GABA Adverse effect: loss appetite, weight loss |
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Levetriacetam |
5.Synaptic vesicle protein 2A binding agents bind to SV2A, inhibit presynaptic Ca channel Reduce NT release |
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Retigabine |
6.Neuronal potassium channel openers MOA: prolonging the opening, stabilize membrane potential (brake neuronal excitability) |
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7.Hormone P E |
P- inhibitory E-excitatory |
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neurotransmitters GABA Glutamate |
GABA - inhibitory Glutamate - excitatory |
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Summary |
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