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7 Cards in this Set
- Front
- Back
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Ionotropic NT Receptors: Mechanism of action |
Intrinsic ion channel that opens on binding NT. Leads to hypopolarization (neg. ions) or depolarization (pos. ions) |
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Metabotropic NT Receptors: Mechanism of action, type of receptor |
Receptor type: GPCR Mechanism: Binding of NT, dissociation of G-protein (alpha, beta, gamma subunits), alpha-subunit signals |
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G-protein alpha-subunit Q function |
Activates Phospholipase-C, which hydrolyzes membrane phospholipids to make IP3 and DAG. DAG: cofactor for protein kinase C (PKC) IP3: Calcium release from sER |
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G-protein alpha-subunit S/I function |
Stimulates or Inactivates Adenylyl cyclase which forms cAMP from ATP, which is cofactor for PKA |
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What must a chemical have to be a NT? (4) |
1) be produced and stored in pre-synaptic neuron vesicles 2) be released in response to pre-synaptic depol. (must be Ca2+ dependent) 3) have high affinity receptors on post-synaptic cells 4) have mechanism for activity termination |
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Excitatory NT's in brain: (2) |
Glutamic Acid (major) & Aspartic Acid (acts on same receptors, but not major) |
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Inhibitory NT's in brain: (2) |
Gamma-aminobutyric Acid (GABA) = brain + SC Glycine = mostly spinal cord |
