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6 Cards in this Set
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Coleman
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parabiosis on ob (normal satiety, no signal) db (no satiety, normal signal) and normal mice. ob+db = on ate less, dB had nvc. dB+normal = normal died. ob+normal = ob ate less. concluded that there was a circulating factor in dB and normal mice.
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parabiosis is sewing together
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London
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injected leptin into 3 ob humans, MRI scan showed a decrease in hunger
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V hypothalamus and L hypothalamus research
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Ventromedial hypothalamus leisioned in rats = overate, so it is the satiety centre in the brain.
Lateral hypothalamus leisioned in rats = reduced eating, hunger centre in brain |
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dual centre model of feeding
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eating->h blood glucose->vh->satiety
^ √ hunger<-Lh<-l blood glucose<-no eat |
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Teitalbaum disproves
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lesioned VH on rats, didn't eat more when more effort was required
lesioned LH, regained appetite after a while |
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Cummings
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Ghrelin increases hunger, so a higher appetite. gastric bands reduce Ghrelin, appetite decreases
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