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9 Cards in this Set
- Front
- Back
Organophosphorous nerve agents activate the endocannabinoid system, the same one affected by delta-9 tetrohydrocannabinol(THC) the psychoactive ingredient in marijuana. TRUE/FALSE
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TRUE
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What is the suspected association between nerve agents and acetylcholinesterase?
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Researchers have long suspected that some effects of sublethal doses of nerve agents cannot be attributed to the inhibition of acetylcholinesterase, the primary target responsible for their toxicity.
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Researchers used a sarin homologue, isopropyl dodecylfluorophosnate(IDFP), that is not selective for Achase to identify possible secondary targets. TRUE/FALSE
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TRUE
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They learned that IDFP inhibits what?
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It inhibits the 2 enzymes primarily responsible for endocannabinoid degradation--monoacylglycerol lipase(MAGL), which metabolizes 2-arachidonylglycerol(2-AG) and fatty acid amide hydrolase(FAAH) which metabolizes anandamide.
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What was found when both enzymes were shut down?
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The level of 2-AG and anandamide in the brain 10 fold. In mice injected with IDFP the researchers saw full blown cannabinoid effects similar to those of cannabinoid receptor agonists such as THC.
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It has been shown that selective FAAH inhibitors raise anandamide levels and elicit the antianxiety and analgesic therapeutic effects of cannabinoids without the cognitive effects. TRUE/FALSE
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TRUE
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What resulted in an increase in 2-AG levels?
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This lead to adecrease in the level of arichidonic acid, a precursor of prostaglandins, which cause inflammation, pain and fever.
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What challenge is presented with an increase in2-AG levels?
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They challenge the conventional wisdom that phospholipase A2 is the main enzyme responsible for the release of arachidonic acid.
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What are prostanoids?
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They are aclass of fatty acids largelt associated with inflammation responses.
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