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9 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What are the best-known trade names for ibuprofen?
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Advil, Motrin, Nuprin
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The name ibuprofen comes from iso-butyl-propanoic-phenolic acid. Ibuprofen has dozens of brand names worldwide.
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What are the functional classes of ibuprofen?
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Antipyretic, analgesic, NSAID
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Ibuprofen also acts as a limited vasodialtor and mild antiplatelet.
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What is the mechanism of action of ibuprofen?
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Ibuprofen inhibits cyclooxygenase (COX) decreasing production of prostaglandins thus decreasing pain sensation, fever, and inflammation.
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Ibuprofen is considered a nonselective COX inhibitor and it is the inhibition of COX-1
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What are the listed indications for ibuprofen?
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Fever
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As an OTC medication, ibuprofen is mainly used for its analgesic and NSAID properties.
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What are the listed contraindications for ibuprofen?
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- Hypersensitivity
- Children less than six months old - GI intolerance such as colitis |
Hypersensitivity to other NSAIDs may indicate hypersensitivity to ibuprofen.
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What are the listed precautions for ibuprofen?
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- Pregnancy
- Peptic ulcer disease - Pulmonary edema - HTN |
Ibuprofen use should be carefully monitored in patients who may be adversely affected by alterations in platelet function, such as those with coagulation disorders or patients receiving anticoagulants.
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What are the listed side effects for ibuprofen?
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- Nausea
- Abdominal pain - Diarrhea - Dizziness - Tinnitus |
Ibuprofen shares the side effects of other NSAIDs.
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What are the listed interactions for ibuprofen?
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- Reduces the effectiveness of loop diuretics and ACE-inhibitors
- Increases hemorrhage potential when given with aspirin |
Ibuprofen increases plasma lithium levels and reduces renal lithium clearance so can induce lithium toxicity.
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What is the dosage and route of ibuprofen?
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Adult:
- 200-600mg PO/PR q 6-8 hours Pediatric: - 10mg/kg PO/PR q 6-8 hours |
OTC ibuprofen directions typically approximate to weight-based dosing and individual doses at home may be higher or lower than 10mg/kg.
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