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6 Cards in this Set
- Front
- Back
MORPHINE
DOA/specials |
Duration of Action
Onset: Immediate. Peak effect: 20 minutes. Duration: 2 - 7 hours. Special Considerations Pregnancy safety: Category C. Morphine rapidly crosses the placenta. Safety in neonate not established. Use with caution in geriatric population and those with COPD, asthma. Vagotonic effect in patient with acute inferior MI (bradycardia, heart block). Naloxone should be readily available as antidote. |
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NALOXONE
Class/MOA |
Class
Narcotic antagonist Mechanism of Action Competitive inhibition at narcotic receptor sites. Reverse respiratory depression secondary to depressant drugs. Completely inhibits t effect of morphine. |
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NALOXONE
I/CI |
Indications
Opiate overdose, coma. Complete or partial reversal of CNS and respiratory depression induced by opioids Narcotic agonist Morphine, heroin, hydromorphone (Dilaudid), methadone. Meperidine (Demerol), Paregoric, Fentanyl (Sublimase). Oxycodone (Percodan), codeine, propoxyphene (Darvon). Narcotic agonist and antagonist Butorphanol (Stadol). Pentazocine (Talwin). Nalbuphine (Nubain). Decreased level of consciousness. Coma of unknown origin. Contraindications Use with caution in narcotic-dependent patients. Use with caution in neonates of narcotic-addicted mothers. |
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NALOXONE
DI/AR |
Adverse Reactions
Withdrawal symptoms in the addicted patient. Tachycardia, hypertension, dysrhythmias, nausea, vomiting, diaphoresis. Drug Interactions Incompatible with bisulfite and alkaline solutions. |
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NALOXONE
How Supplied |
How Supplied
0.02 mg / ml (neonate); 0.4 mg/ml, 1 mg/ml; 2.0 mg / 5 ml ampules; 2 mg/5 ml prefilled syringe. |
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NALOXONE
Dosages |
Dosage and Administration
Adult: 0.4 - 2.0 mg IV, IM, SC, Nasal via atomizer; min. recommended = 2.0 mg repeat at 5 minute intervals to 10 mg maximum dose. (Medical Control may request higher amounts). Infusion: 2 mg in 500 ml of D5W (4 mcg/ml), infuse at 0.4 mg / hr (100 ml/hour). Pediatric: 0.1 mg / kg / dose IV, IM, SC; maximum of 0.8 mg; if no response in 10 minutes, administer an additional 0.1 mg / kg /dose. |