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11 Cards in this Set
- Front
- Back
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Mycobacterium |
Aerobic, acid fast bacilli May stain weakly gram positive |
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What does acid fast refer to? |
The ability to retain stain carbofuchsin despite addition of acid-alcohol |
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Mycobacterium tuberculosis Clinical |
Obligate Aerobes so like the lungs (initial infection) If contained produces Ghon complex Immunosuppressed/young child may not contain, will turn into primary TB pneumonia Reactivation can occur years later Symptoms include fever, fatigue, night sweats, weight loss, cough, hemoptysis (coughing blood) |
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Ghon Complex |
a lesion seen in the lung that is caused by tuberculosis. The lesions consist of a calcified focus of infection and an associated lymph node. "pulmonary granuloma and associated hilar adenopathy" |
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M. tuberculosis Pathogenesis |
Resists immune system Contained in caseous granulomas Cord Factor: inhibits migration of leukocytes, causes growth in chains Mycolic Acid: causative agent of tuberculosis |
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M. Tuberculosis Lab Diagnosis |
Acid fast bacilli Slow growing Obligate Aerobe Cat - Niacin + |
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M. Tuberculosis treatment |
Long term drug regimens INH (isoniazid; inhibits mycolic acid production) Vaccine may prevent in children |
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Mycobacterium Leprae |
Leprosy Tuberculoid (mild) or Lepromatous (severe) Types Skin anethesia -> burns, trauma, reabsorption of bone May resolve quickly in patients with single lesion and intact immune reponse Lives in human skin and nerves Grows under skin (because core temp too high) within histiocytes, endothelial cells, and schwann cells |
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M. leprae Lab Diagnosis |
Aerobic, acid fast bacilli Lepromin Skin test |
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M. leprae treatment |
Dapsone, rifampin +/- clofazimine Treat close family with dapsone |
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Why is the fact that mycobacterium are resistant to acids and alkali useful for lab work? |
It means that you can kill off other respiratory flora and culture mycobacterium. |
