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13 Cards in this Set
- Front
- Back
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Clomiphene
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INFERTILITY
Competitive antagonist of the estrogen receptor (BOTH ERa & b) Artifically INDUCES ovulation therefore good for INFERTILITY Block estrogen-mediated negative feedback in the pituitary |
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Raloxifene
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Treat Breast Cancer
Estrogen agonist in the BONE Does not have agonistic activity in the uterus used mainly to prevent OSTEOPOROSIS |
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Tamoxifen
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Breast Cancer treatment
may be used PROPHYLACTICALLY Estrogen receptor antagonist in the breast; agonist in the endometrium cease use after 5 years to avoid drug-resistant breast tumors SE: ENDOMETRIAL BLEEDING, uterine cancer |
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Mifepristone
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RU-486
Abortifacient for the 1st trimester |
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Leuprolide
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Analog of GnRH
With chronic administration v pituitary gonadotropin production (after initial increase) |
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Finasteride
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Prostatic Hyperplasia
5A-reductase inhibitor Antiandrogen B/c prostate growth is dependent on DHT rather than testosterone |
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Danazol
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Synthetic steroid ethisterone
A modified testosterone used to treat ENDOMETRIOSIS |
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Norethindrone
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Synthetic progestin
Hormonal contraceptive only active in the presence of estrogen and the primed estrogen system |
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The 3 Adrenal Zones and their products (from capsule to medulla)?
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Zona Glomerulose - aldosterone
Zona Fasciculata - cortisol Zona Reticularis - androgens |
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Fludrocortisone acetate
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GLUCOCORTICOID (cortisol-like) & MINERALOCORTICOID (aldosterone-like) activity
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Difference b/w NSAIDs and Glucocorticoids
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Glucocorticoids also inhibit leukocytes and macrophages that contribute heavily to inflammation
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Aminoglutethimide
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Inhibits the synthesis of all hormonally active steroids
Blocks the conversion of cholesterol to pregnenolone Used to reduce glucocorticoid levels in patients with Cushing's as well as other things such as prostate and breast cancer |
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Benefit of Aromatase Inhibitors over Tamoxifen?
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Aromatase Inhibitors do not increase the risk of uterine cancer or venous thromboembolism
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