Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
What is SLE? |
Production of antibodies against nucleic acids, erythrocytes, coagulation proteins, phospholipids, lymphocytes, platelets, etc |
|
What is the most characteristic autoantibodies produced in SLE against? |
Nucleic acids and other DNA material |
|
Who is SLE most common in? |
20-40yo, blacks > whites |
|
What is the triad of symptoms? |
Fever, joint pain (asymmetrical), facial rash in women of childbearing age |
|
What are other common clinical findings in SLE? |
Facial rash Photosensitivity Oral/NP ulcers Renal/neuro disease Hematological disorders Cardiovascular disease (pericarditis) |
|
How is SLE diagnosed? |
ANA, CRP, complement levels, x-ray, ECG, lumbar puncture, renal biopsy, and skin biopsy |
|
How is SLE treated? |
NSAIDs, antimalarial (hydroxychloroquine), corticosteroids, immunosuppressive drugs (methotrexate, azathioprine), IVIG is temporary |
|
ABO are _______ Universal donor: ___ Universal acceptor: _____ |
ABO are antigens Universal donor: O Universal acceptor: AB |
|
What does the RhD protein tell you? |
tells you if the person is positive or negative patients who express the D antigen on the RhD protein are Rh-positive (dominant "D") patients who do not express the d antigen on the RhD protein are Rh-negative (lowercase "d") |
|
What genotypes will an Rh positive person have? Rh negative? |
Rh positive - DD or Dd since D is dominant Rh negative - dd |
|
What immune response will occur with an Rh negative mother and an Rh positive baby? |
Hemolytic anemia |
|
Primary vs secondary immune deficiencies |
Primary - congenital Secondary - acquired (by another illness i.e. cancer, aging, virus) *more common* |
|
What are the 5 groups of primary immunodeficiencies? |
B-cell deficiencies T-cell deficiencies (affects B cells thus lacks antibodies) Combined B and T cell deficiencies Complement deficiencies Phagocytic deficiencies |
|
What is DiGeorge syndrome? |
Partial or complete absence of T-cell immunity |
|
|
|