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33 Cards in this Set
- Front
- Back
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Which antigen is common in South American Indians and Siberian Inuits? |
Diego a (Dia) |
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What are the most common Diego antigens? |
Dia, Dib, Wra, and Wrb |
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Which Di antibodies are clinically significant?
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anti-Dia and -Dib |
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Which Diego antibody is relatively common? |
anti-Wra |
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Which antibodies are found in AIHA and may be clinically significant? |
anti-Wra and anti-Wrb |
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What antigens belong to the Cartwright group? |
Yta and Ytb (IgG antibodies) |
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What is the importance of the Cartwright (Yt) antibodies? |
IgG antibodies, they cause HTR but not HDFN |
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What ISBT number is assigned to the Cartwright group? |
YT 011 |
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What ISBT number is assigned to the Xg group? |
XG 012 |
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Which miscellaneous antigen is controlled by an X-linked gene? |
Xga (controlled by Xg): so only women can be homozygous for this antigen |
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What ISBT number is assigned to the Scianna group? |
SC 013 |
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What ISBT number is assigned to the Dombrock group? |
DO 014 |
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CD99 is controlled by MIC2, not X-linked, so why is it grouped with Xg? |
They are located close to each other on the chromosome |
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What ISBT number is assigned to the Chido/Rogers group? |
CH/RG 017 |
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What are the characteristics of Chido/ROgers group? |
1. not on RBC membrane but on C4 then adsorbed onto RBC 2. 9 antigens 3. antibodies are IgG 4. not significant for RBC transfusions 5. have caused anaphylaxis with plasma transfusions 6. AKA high titer low avidity antibodies (HTLA) 7. can mask detection of other clinically significant antibodies but can be neutralized with pooled plasma |
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Which antigens are in the 200 series? |
207: Ii collection (i antigen) 209: Globoside collection (Pk and LKE antigens) 205: cost collection 208: Er collection 210: Lec and Led 212: VEL collection (formerly in the 901 series) |
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What characteristics belong to the low frequency series (700)? |
1. must have frequency < 1% 2. must be inherited 3. must not be part of an existing system or related closely 4. must be serologically different from other antigens 5. antibody and RBC with antigen must be available 6. 18 antigens currently |
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What characteristics belong to the high frequency series (901)? |
1. must have frequency > 90% 2. must be inherited 3. must not be part of an existing system or related closely 4. must be serologically different from other antigens 5. 8 antigens currently 5. antibodies are often significant and very difficult to find compatible blood |
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Which of the high frequency series antibody is dangerous IgG that causes HTR and HDFN? |
anti-Lan |
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Which high frequency series appear as classic mixed field? |
Sid and Cad (anti-Sda) |
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T/F: Sda antigens have consistent reactions |
False; Sda antigen expression varies so reactions are negative to strongly positive |
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Which high frequency antibody is very common? |
anti-Sda |
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Which antigen in the high frequency series is associated with Tamm0Horsfall protein? |
Sda (in the urine) |
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What can be used to neutralize strong interfering anti-Sda? |
urine |
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Cad antigen are super strong _______________ |
Sda -polyagglutinable -react with Dolichos biflorus -Cad cells are resistant to P. falciparum |
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White cell antigens are gene products of what? |
MHC |
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White cell antigens belong to what series? |
Bg series |
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How many Bg antigens are there? |
3: Bga, Bgb and Bgc |
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What is the importance of Bg antigens? |
residual amounts of Bg in RBC from nucleus stage |
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What is the ISBT number assigned to the Bg antigens? |
none |
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Which of the miscellaneous antibodies are known as nuisance antibodies? |
Bg antibodies |
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Which of the miscellaneous antibodies can absorb out with platelets? |
Bg antibodies |
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What are the characteristics of Bg antibodies? |
1. IgG 2. weak and variable AHG activity (rx with one or two panel cells) 3. more common in multiply transfused or multiparous women |
