Mim Lecture 1

Front 1

1.1

central immune organs

Back 1

immune cell generation and maturation

Front 2

1.2

peripheral organs

Back 2

antigen recognition and immune cell activation

Front 3

1.3

lymph organ

Back 3

carries antigen to nodes and lymphocytes back to blood

Front 4

1.4

pluripotent stem cells

Back 4

precursor for blood-forming (hematopoietic) system

Front 5

1.5

lymphocytes

Back 5

B, T, NK

Front 6

1.6

myeloid

Back 6

monocytes
macrophages
dendritic cells
granulocytes

Front 7

1.7

immunogen

Back 7

substance that induce immune response

Front 8

1.8

antigen (Ag)

Back 8

substance that react w/ the product of the immune response

Front 9

1.9

autoreactive

Back 9

- reactive to both self and non-self
- bind strongly to other cells of the body
- eliminated
- deletion, anergy (unresponsive), suppresion

Front 10

1.10

tolerant/educated

Back 10

no response to self

Front 11

1.11

B lymphocytes

Back 11

make and secrete antibodies (antigen receptor)

Front 12

1.12

cytotoxic

Back 12

T cells killing the pathogens

Front 13

1.13

dendrites/macrophages

Back 13

take antigens and break them up to pieces (processing) and present them to T cells
- professional antigen presenting cells

Front 14

1.14

macrophages, neutrophils

Back 14

active in early immune response => phagocytic cells

Front 15

1.15

basophil, eosinophil, mast cells

Back 15

inflammation

Front 16

1.16

CB3

Back 16

T cell receptor, TCR

Front 17

1.17

antibody reagents

Back 17

used in the lab to tell cells apart between their cell surface proteins

Front 18

1.18

perforin

Back 18

create hole in the membrane of target cell and kill it

Front 19

1.19

Th1

Back 19

- cytokine interferon-gamma
- activation of macrophages

Front 20

1.20

cell surface molecules distinguish cells by:

Back 20

function, stages of differentiation and activation, secreted small molecules (cytokines)

Front 21

1.21

Th2

Back 21

interleukin 10 => B lymphocyte/antibody (humoral) response

Front 22

1.22

antigen presentation

Back 22

MHC binds to a piece of the pathogen (antigenic peptide) and brings it up to the cell surface => visible to the immune system

Front 23

1.23

interaction of CD3 & TCR

Back 23

sends activation signal into T lymphocytes to activate and proliferate

Front 24

1.24

CD4/8 -> MHC

Back 24

T lymph and MHC adhere together long enough for signaling

Front 25

1.25 CD28 -> CD80/86 (B7)

Back 25

naive T cell need second signal to become activated

Front 26

1.26

immunologic synapse

Back 26

small area b/w cells that contain lots of receptors and ligands
- brought on by CD28-CD80/86 (B7)

Front 27

1.27

CHEMOKINES

Back 27

a cytokine that causes cell to migrate

Front 28

1.28

cytokines

Back 28

when cell receive activating signal => they release these little proteins that are hormone like => bind cell surface receptors on a variety of cells => stimulate lots of things

Front 29

1.29

systemic cytokines

Back 29

cause systemic effects: fever, shock, liver produce acute phase proteins

Front 30

1.30

effector cells

Back 30

fight infection non-specific

Front 31

1.31

toll-like receptors on macrophages

Back 31

recognize molecular patterns not found in human but are in microorganisms

Front 32

1.32

complement systems

Back 32

antibacterial proteins

Front 33

1.33

antibody receptor, structure of

Back 33

2 identical antigen binding arms

Front 34

1.34

activation of B cells

Back 34

- B meet T in lymph node
- B antibody interact w/ activated T thru cell surface or cytokines

Front 35

1.35

cytotoxic T lymphocytes

Back 35

- helped by helper T
- goes to the infection site and destroy pathogen

Front 36

1.36

IgG

Back 36

- most common antibody
- transfered from mother -> fetus

Front 37

1.37

IgA

Back 37

- passed via breast milk
- secretions: lung, gut

Front 38

1.38

IgE:

Back 38

parasites, mast cells, allergy

Front 39

1.39

IgM

Back 39

bind to microbes

Front 40

1.40

IgD

Back 40

B cell maturation

Front 41

1.41

complement cascade

Back 41

- series of blood proteins bind onto antigen/antibody in sequential order
- each step, protein is cleaved, enzyme and small peptide released
- stimulate inflammation

Front 42

1.42

C1

Back 42

- first protein in complement cascade
- detect antibody bound to antigen

Front 43

1.43

membrane attack complex

Back 43

- if antibody bound to cell => final stage is membrane attack complex that can attack the cell membrane of pathogen

Front 44

1.44

immune response for parasites

Back 44

- IgE antibody
- mast cell, eosinophills, basophils

Front 45

1.45

immune response for intracellular vesicles

Back 45

macrophage activation

Front 46

1.46

immune response for intracellular cytoplasmic

Back 46

NK cells

cytotoxic T lymphocytes

Front 47

1.47

immune response for extracellular

Back 47

IgG antibody

complement

phagocytosis

Front 48

1.48

DiGeorge syndrome

Back 48

- deletion chromosome 22
- lack of thymic development
- T lack place to mature

Front 49

1.49

lupus (SLE)

Back 49

attack chromatin./DNA-protein

Front 50

1.50

Type I hypersensitivity:

Back 50

- allergy, asthma, systemic analphylaxis
- mast cells and IgE
- bee sting

Front 51

1.51

Type II hypersensitivity

Back 51

- penicillin allergy
- IgG, complement and phagocytic cells

Front 52

I.52

Type III hypersensitivity

Back 52

- IgG
- serum sickness

Front 53

1.53

Type IV hypersensitivity

Back 53

- helper or cytotoxic T cells
- poison Ivy
- delayed type hypersensitivity (DTH)