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16 Cards in this Set
- Front
- Back
- 3rd side (hint)
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MHC : -Are -MCQAbsent in... -Have same or diff AA... -Ayman MCQ Classes w present where... -MCQ What carry all classes... -Ayman MCQ F45 Classes displaying Ag to which T cells -Ayman Which Class present in Exogenous |
Self - ptns (Self Ag)
RBCs
Diff
Class I MHC > all nucleated cells Class II MHC > APC (MAC w Dendritic cells)
APC
Class I > Tc (CD8) Class II > Th (CD4) II |
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MCQ 1)CMI : - Mediated by -Against EC or IC ... 2)Humoral : -Mediated by... -against EC or IC |
T Lymphocytes
IC
B Lymphocytes
EC |
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MCQ Ayman
cells involved in CMI |
- APC - T Lymphocytes (Th w Tc) |
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T Lymphocyte Percent of total blood Lymphocytes... Arise from... Mature in... Receptors Carrying |
65-80%
BM
Thymus
- CD4 - CD8 - TCR Complex - CD3 |
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TCR T cell receptor : -Ayman Specific to how many epitope -MCQ Marked what -Ayman How many polypeptide chain CD3 : -MCQ Ass with w to form -Ayman MCQ F45 Role of CD3 |
One (specific)
Diversity Allowing Recognition of millions of epitopes
2 a w B Variable w Constant
TCR... TCR Complex
Transmitting Signals |
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MCQ Ayman مهم فشخ CD4 Called... Percent of T cells... Which MHC... CD8 Called... Percent... Which MHC... |
Th
65% Class II
Tc
35% Class I |
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Activation of CD4 Th... -Produce - Is it Kill -.in which lymphoid Organs -Ayman MCQ F45 Which MHC class - Ayman MCQ CD4 interact with this MHC why w TCR interact with this MHC why -Ayman Binding of APC TO TCR also involves MCQ:Adhesion molecules so what are these molecules w these molecules bind with what. - MCQ:Once activated CD4 Replicate producing -Ayman MCQ F45 A) APC Must be 4P B) IL-1 activate what C) اقوي Stimulation w form IL D) When B7 with CTLA-4 this action E) If Ag binding without Co Stimulation so = |
Cytokines
No
2ry (LN w Spleen)
II...
Stabilization(Clamping) ... Recognition
Adhesion molecules : - ICAM 1 (IC Adhesion molecules) with LFA 1 (Lymphocyte functional Ag) - LFA 3 with CD2
Effector cells (Th1 w Th2) w Memory cells
A) - Ptn -Process تكسير -Phagocytosis -Present (MHC II)
B) Th
C) B7 with CD28.. IL-2 ➡️➕T cell
D) ➖IL-2 ➡️➖Tcell E) Anergy or No Response |
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MCQ Effector cells are |
Th1 w Th2 |
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AYMAN MCQ F45
1)TH1: -Help which adaptive Immunity - Secrete which cytokines - Promote function of -AB class switching to which Ig 2) TH2 : - Help which adaptive Immunity -. Secrete which cytokines -Promote function of - AB class switching to which Ig
MCQ :Which Type involved in Allergic w Manifestations |
CMI (Delayed-Type hypersensitivity)
IL-2 w IFN Gamma
MAC w Tc w NK w B Lymphocytes
IgG
Humoral
IL-4 w 5 w 6 w 10 w 13
B Lymphocytes
IgE
TH2 |
مينفعش CMI و Humoral في نفس الوقت |
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Activation of CD8 Tc : Ayman -As Th xpt : -Mech of Killing by Tc |
MHC I CD8 IL-2 not IL-1 Endo Ag -Direct : Perforin Pathway (Cytoplasmic granules) -Fas L (CD95L) Fas Pathway ➡️Binding of FasL with Fas CD95 ➡️Apoptosis |
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Similarity between Tc pathways is |
Causing Apoptosis |
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Memory T cells - In 1ry or 2ry IR -Amount of Ag needed |
2ry
Small |
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Superantigens. Ayman - MCQ In contrast to classic it is -MCQ Ex -MCQ Binds to -outside or inside the AP groove W MCQ cross linking it to Which MHC -MCQ F45 allows what w with Release of w Release of what from T cells w Release of what from MAC - MCQ This may lead to |
Not processed by APC
Toxin A (toxic shock Syndrome) w Rabbits
B chain of TCR
outside ... MHC II
Polyclonal Activation... Large amounts of cytokines... IL-2 w IFN-Gamma... IL-1 w TNF-a
Shock |
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MCQ Down Regulation of CMI By |
Tr CTLA-4 (Cytotoxic T Lymphocytes ass ptn-4) |
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Ayman T Regulatory -Percent of CD4 -MCQ .. Marker -Activated by -MCQ When they activated what secrete.. -Eff on IR |
5-10 % عشان جزء من الTh
CD25 IL-2
IL-10 w TGF-B
-ve response |
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CTLA-4 : -When it appear -MCQ F45 Bind to instead of -MCQ So inhibits -Eff on IR |
When T activated (سواء Th or Tc)
B7 .... CD28
T cell Activation
-ve response |
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