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30 Cards in this Set
- Front
- Back
how does skin prevent bacterial colonization
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dry
slightly acidic keratinzed cells sloughs off lysozyme - degrades peptidoglycan normal microbiota - compete for nutrients and colonization sites langerhans cells |
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this enzyme in sweat hair follicles and tears degrades peptidoglycan
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lysozyme
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these are dendritic cells of the skin - kill bact. where?
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langerhans cells
reside underneath epidermis in: SALT - skin assoc lymph tissue |
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defenses in Resp tract, GI tract, and Uroge tract?
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1. Mucus - traps and explled
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how does skin prevent bacterial colonization
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dry
slightly acidic keratinzed cells sloughs off lysozyme - degrades peptidoglycan normal microbiota - compete for nutrients and colonization sites langerhans cells |
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what proteins are there in mucus to protect?
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1. lysozyme
2. lactoferrin - sequesters iron from bact 3. defensins - toxic peptides put holes in bacteria 4. immune proteins - sIgA |
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this enzyme in sweat hair follicles and tears degrades peptidoglycan
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lysozyme
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these are dendritic cells of the skin - kill bact. where?
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langerhans cells
reside underneath epidermis in: SALT - skin assoc lymph tissue |
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defenses in Resp tract, GI tract, and Uroge tract?
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1. Mucus - traps and explled
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what proteins are there in mucus to protect?
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1. lysozyme
2. lactoferrin - sequesters iron from bact 3. defensins - toxic peptides put holes in bacteria 4. immune proteins - sIgA |
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this sequesters iron from bacteria. where in body/?
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lactoferrin
in mucus |
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this kills bact by poking holes in membrane -Where?
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defensins
mouth tongue ingestine - in mucus |
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These things bind and neutralize in mucus
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immne proteins - sec IgA
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all mucosal surfaces are protected by normal microbiota. T/F?
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no - uterus not uccupied
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What lies underneath mucus to help protect
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MALT - mucosa assoc lymph tissue
GALT - gastrointestinal a l t make macroaph T cells B cells IgA |
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what are the nonspecific defenders of the body
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phagocytes and nonspecific cytotoxic cells
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What are different kindso f phagocytes?
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1. polymorphomuclear leukocytes/neutrophils - short lived
2. monocytes - different into dendritic of macroph 3. macraph - chew up and present antgiens 4. dendrtic cells - chew up and present 5. mast cells - congregate around blood cells - vasodilation via histamine - increase circulation to aid in fight |
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give example of cytotoxic cells?
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Natural killer cells - attacks infected cells
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this pathogen survives the lymph nodes (bact)
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yersinia pestis
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what are lysosomal components of phagocytes?
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degradative enzymes - lyso and prote
defensins - proe form myelperoxidase - |
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this protein guides where phagocytes should go
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cytokines and chemokines
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how do NK cells work?
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bind to target infected cell - release toxins contained with granules
1. perforin 2. granzymes - action protein through channels formed by perforin - stim apop |
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What is main killer against bacteria? against virus?
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b - phagocytes - ingest with enzymes
V - NK cells induce apop |
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diff btwn innate and adaptive immune sys
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innate - non specific attack to degrade pathogens - 1st line of defense - immediate
adaptive - memory response to specific pathogens - initiated when innate resp not adequate (4days) - lasting immunity |
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these cells degreade and presnet antigens
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dendritic and macroph
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cells from bone marrow. function?
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B cells - produce antibodies
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lymph cells from thymus. fuction?
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T - cells - recognize antigens - stim cell medi immune resp
cytotoxic t cells (CD8) - kill infected cell Helper T cells - help recog cell that is infected |
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parts of antibody\
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constant heavy chain - binds to recptor on immune cells = Fc region
variable light chain - binds to antigen - always changing for recog and speci = V region |
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this is teh process through which lymphocytes specific to disease are formed
how |
clonal selection
progenitor cell - makes diff lymphcytes each with diff specific those that bind to self antigens are deleted match with foreign antigen causes proliferation of a specifc lymph - clones of effector cells |
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the promotion of ingestion and killing by phag cells
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opsonoization
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