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20 Cards in this Set
- Front
- Back
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Drugs that inhibit adsorption -- dont let virus attach to host
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Tamiflu - prevents adsorportion of the influenza virus and T20 - HIV - fusion inhibitor
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Drugs that are protease inhibitors wich prevent protein synthesis
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sequinavir which treats HIV
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azoles (suffix)
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fluconazole - intereferes with lipid biosynthesis
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Quinolones-ceprofloxacin
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inhibits DNA synthesis and has a broad spectrum
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tetracycline - other cyclines
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bind to 30s robosome -- broad spectrum can eliminate normal flora, stain teeth, and cause damamge to the liver and kidney
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sulfa drugs
sulfanilamide and trimethoprim |
inhibitors of folic acid synthesis can be given together in form of bactrin
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Drugs that inhibit viral nucleic acid synthesis
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acylovir - herpes AZT - HIV works as a competitive inhibitor
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rifampin
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targets RNA polymerase, ecreases MRNA production, inhibits RNA synthesis and has a broad spectrum
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Problem with ANtivirals
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selective toxicity
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chloraquine
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treats malaria targets DNA
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aminoglycosides - streptomycin
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affects 30s ribosomes -- inhibits protein synthesis -- G- -- toxic to kidney and hearing
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Protein synthesis inhibition
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target bacterial ribosomes 30s + 50s = 70s
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polygenes - target sterols
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amphotericin and nystatin
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griseofulvin
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treats skin, hair, nail infections by interfering with mitosis
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Drugs that inhibit penetration or uncoating
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amantadine - treats influenza A infections prevents uncoating
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chloramphenical
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bind ot 50s ribosomes, broad spectrum, can cause anemia and loss of normal flora
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Competitive Inhibitors
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look like the substrate
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Protozoan problems
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selective toxicity must have knowledge of the life cycle
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metrohizadole
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treats STDs and gastro intestional tract parasites, also targets DNA
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concerns with water microbiology
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water can transmit pathogens if it is contaminated source of contamination is fecal, Normal flora in water is involved with natural purification
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