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40 Cards in this Set
- Front
- Back
Clinical manifestations of Brucellosis?
|
flulike symptoms
undulant fevers bone/joint infections CNS infections |
|
Forms of anthrax?
|
Cutaneous
Gastrointestinal Inhalational |
|
Clinical manifestations of Tularemia?
|
Ulceroglandular (eschar)
Oculoglandular Glandular Typhoidal Pulmonary Pharyngeal |
|
Clinical manifestatsions of Capnocytophaga canimorsus infection?
|
fulminant sepsis
disseminated intravascular coagiulation |
|
Major animal reservoirs of plague?
|
GREAT KAZAKHSTAN GERBIL
Prairie dogs, other rodents |
|
Francisella tularensis immune evasion mechanisms?
|
-obligately intracellular
-nonimmunogenic LPS -phase variation |
|
Brucella spp. virulence factors?
|
-Type IV secretion system
-survives inside phagocytes -shuts off immune response via B cell mitogen |
|
Francisella tularensis virulence factors?
|
30kb pathogenicity island
induces caspase-1 dependent host cell death |
|
Clinical manifestations of Pasteurella multocida infections?
|
skin/soft tissue infections
osteomyelitis respiratory tract infections |
|
Clinical manifestations of Streptobacillus moniliformis infections?
|
Rate Bite Fever
fever (duh) migratory polyarthralgias rash on dorsal surface of hands, soles of feet |
|
Virulence factors of Pasteurella multocida?
|
phage-encoded toxin
constitutively activates G proteins --> mess up signaling induces actin polymerization |
|
Reservoir of Pasteurella multocida?
|
respiratory flora of birds, cats, dogs
|
|
Reservoir of Capnocytophaga canimorsus?
|
mouth flora of dogs and cats
|
|
Reservoir of Streptobacillus moniliformis?
|
normal upper respiratory flora of rats
|
|
Reservoir of Francisella tularensis?
|
rabbits
free-living amoebae |
|
Reservoir of Bacillus anthracis?
|
environment
|
|
Special growth needs of F. tularensis?
|
cysteine
|
|
Reservoir of Brucella spp?
|
cows/bison (B. abortus)
pigs (B. suis) sheep/goats (B. melitensis) dogs (B. canis) |
|
How is Brucellosis transmitted?
|
-consumption of unpasteurized dairy products
-sometimes infects through mucous membranes/inhalation |
|
Transmission of tularemia?
|
arthropod vectors
contact w/infected rabbits |
|
prophylaxis of Brucellosis?
|
pasteurize dairy products
vaccinate goats, sheep, etc. |
|
Transmission of C. canimorsus infections?
|
animal bites
|
|
Colonial morphology of Bacillus anthracis?
|
"ground glass"
nonhemolytic medusa head border tacky consistency may produce capsule in ++CO2 |
|
Pathogenicity of B. anthracis?
|
basically turns host into culture media
obliterates innate immune system communication: p38, Nalp1 inflammasome overwhelming infection, hemhorrage, necrosis, liver failure antiphagocytic D-glutamate capsule, siderophores, cytolysin |
|
Disease course of inhalational anthrax?
|
prodrome (malaise, flulike symptoms but no runny nose or headache/body aches)
brief asymptomatic period indicative of immune system collapse all hell breaks loose: hemhorrage, respiratory distress, shock, meningitis, death |
|
prophylaxis of Brucellosis?
|
pasteurize dairy products
vaccinate goats, sheep, etc. |
|
Components of anthrax toxin?
|
PA = protective antigen, B subunit
LF = lethal factor (MAPKK cytotoxin) EF = edema toxin (cAMP toxin) ejected into cell upon acidification of endosome. |
|
Transmission of C. canimorsus infections?
|
animal bites
|
|
How is inhalational anthrax spread?
|
only through inhalation of airborne spores.
NO P2P spread! |
|
Colonial morphology of Bacillus anthracis?
|
"ground glass"
nonhemolytic medusa head border tacky consistency may produce capsule in ++CO2 |
|
Tx of anthrax?
|
NO BETA LACTAMS! (resistant)
fluoroquinolone/doxy + rif or clindamycin MUST treat during prodrome, treat for 60 days due to spores |
|
Pathogenicity of B. anthracis?
|
basically turns host into culture media
obliterates innate immune system communication: p38, Nalp1 inflammasome overwhelming infection, hemhorrage, necrosis, liver failure antiphagocytic D-glutamate capsule, siderophores, cytolysin |
|
Dx of anthrax?
|
x-ray/CT: widened mediastinum
serology: anti-cell wall AB's PCR bacteriophage sensitivity rapid immunochromatographic tests gram stain: large bamboo GPR normal WBC count. |
|
Disease course of inhalational anthrax?
|
prodrome (malaise, flulike symptoms but no runny nose or headache/body aches)
brief asymptomatic period indicative of immune system collapse all hell breaks loose: hemhorrage, respiratory distress, shock, meningitis, death |
|
Which zoonoses activate caspase-1 cell death pathway?
|
B. anthracis
F. tularensis |
|
Components of anthrax toxin?
|
PA = protective antigen, B subunit
LF = lethal factor (MAPKK cytotoxin) EF = edema toxin (cAMP toxin) ejected into cell upon acidification of endosome. |
|
How is inhalational anthrax spread?
|
only through inhalation of airborne spores.
NO P2P spread! |
|
Tx of anthrax?
|
NO BETA LACTAMS! (resistant)
fluoroquinolone/doxy + rif or clindamycin MUST treat during prodrome, treat for 60 days due to spores |
|
Dx of anthrax?
|
x-ray/CT: widened mediastinum
serology: anti-cell wall AB's PCR bacteriophage sensitivity rapid immunochromatographic tests gram stain: large bamboo GPR normal WBC count. |
|
Which zoonoses activate caspase-1 cell death pathway?
|
B. anthracis
F. tularensis |