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26 Cards in this Set
- Front
- Back
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Antigen Immunogen Allergen Ag |
Any substance that can cause antibody formation can be A microbe, foreign material, or self Usually proteins or large polysaccharides |
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Antibody Immunoglubulin Ab Ig |
protein made in response to an antigen recognize and bind to Ag |
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Antigen Antibody reaction |
Ab will attach to the Ag at a specific site Valence: # of Ags that will attach to Ab |
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Active Body makes own Ab How are we exposed to Ag |
Natural active come across the antigen naturally : cold virus Artificial active Ag introduced artificially (vaccine) MMR DPT or DTaP HIB |
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Passive Ab from animal/human How are we exposed to Ag |
Natural passive Ab goes from mother to infant Placental or colostrum
Artificial passive Ab recieved via injection Examples: antitoxin (antiserum) or Rhogan (anti Rh antisera) |
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Hemolytic disease of newborn HDN |
Rh neg mother and Rh pos father could produce antibodies against Rh blood |
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Serum electrophiresis: Gamma Globulin portion of serum |
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IgA Gamma A immuno globulin a Secretory Ab |
MW 70,000 or 400,000 Daltons (2 mw) found in: mucous, saliva, tears, colostrum and blood 1st and 3rd line of defense 13% of total WBC but % higher in total secretions of the body monomer in blood dimer in secretions |
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IgD Gama D |
MW 180,000 daltons internal marker on B lymphocytes 0.2% of total WBC monomer |
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IgE Gama E |
Allergen Ab MW 200,000 Daltons (single Y) involved in hypersensitivity or allergic rxns 0.002% of total Ab monomer least abundant |
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IgM Gamma |
circulatory Ab MW 900,000 Daltons largest Ab 1st Ab to arrive in response to initial exposure of Antigen short lived doesn't cross fetal-placental membrane 6% of total Ab pentamer |
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Antibody memory Anamnestic response |
Initial 4-7 days IgM 10-17 days IgG (triggers compliment) Secondary: 2-7 IgG with greater magnitude (higher tider) |
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Antibody structure |
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Antibody structure of a monomer |
4 polypeptide chains: 2 heavy 2 light |
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T cells and cell immunity |
Produced by stem cell in red bone marrow Mature in thymus Make up-65% of total"r-- lymphocytes Responds to Ags and F\g. 17.1 F.- results in the formation of certain subsets of T Secrete cytokines: r A 'C q Bdjdjdjjd |
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Types of T cells |
T helper cells Pg 8 |
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Regulator T cells |
Suppressor CD8 cell Suppress other T cells |
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Cytotoxic cells |
Tc a CD8 Recognize and kill target ce\\s, "non-self"or hijacked ce\\S, tumor cells and transplanted foreign tissue · Programmed ce\\death: Apoptosit |
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Cytokines |
Chemical messengers of immune ce\\S Also known as: Function: Attract macrophages, protect · otect against viral\nfecuons, toxic to tumor cells, Increase Ab producuon Pg9 |
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B cells and humoral immunity |
Produced by stem cells mature in red bone marrow Named for bursa of fabricius (chicken GI ) djkdke pg9 |
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B cells |
Carry-0ld"Immunoglobulins (IgD or M) on surface. When they recogn\ze an hg, the B ce\\ls acuvated w\th the ass\stance of TH ce\\S to produce, 1. Memory Ce\\S 2, Plasma Ce\\S'. |
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Results of anti |
A |
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Types of mechanism (antibody...) |
Agglutination reduce # of microbes
Pg11 |
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IgG Gama G |
circulatory Ab MW 160,000 daltrons protects against microbes, triggers complement and incr phagocytosis crosses fetal-placental membrane 80% of total Ab most abundant monomer |
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Antibody structure of a monomer Arms of Y: |
fab region(fragment of Ag binding)Region where Ag binds Contains variable amino acid sequence Specific for Ag |
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Antibody structure of a monomer Stem of Y |
: Fc region (fragment of cell binding) Contains amino acid sequencebinds to, cells , proteins, or compliment |
